Static Magnetic Field Direction-Induced Differential Biological Effects

Yu, Biao; Zhang, Xin

doi:10.1007/978-981-19-8869-1_2

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…However, investigation into the intrinsically magnetic cells has thus far been limited, leaving a substantial gap in our understanding of their magnetic properties and the biological significance thereof. While studies have suggested that magnetic fields may influence immune system regulation, [5][6][7] the precise mechanisms driving this influence remain to be fully clarified. Consequently, the naturally occurring intrinsically magnetic cells could potentially serve as important functional targets for the effects of these magnetic fields.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Characterization of Human Intrinsically Magnetic Monocytes Through a Novel Optical Tracking‐Based Magnetic Sensor

Wu,

Zhang,

Zhao

et al. 2024

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Intrinsically magnetic cells naturally occur within organisms and are believed to be linked to iron metabolism and certain cellular functions while the functional significance of this magnetism is largely unexplored. To better understand this property, an approach named Optical Tracking‐based Magnetic Sensor (OTMS) has been developed. This multi‐target tracking system is designed to measure the magnetic moment of individual cells. The OTMS generates a tunable magnetic field and induces movement in magnetic cells that are subsequently analyzed through a learning‐based tracking‐by‐detection system. The magnetic moment of numerous cells can be calculated simultaneously, thereby providing a quantitative tool to assess cellular magnetic properties within populations. Upon deploying the OTMS, a stable population of magnetic cells in human peripheral monocytes is discovered. Further application in the analysis of clinical blood samples reveals an intriguing pattern: the proportion of magnetic monocytes differs significantly between systemic lupus erythematosus (SLE) patients and healthy volunteers. This variation is positively correlated with disease activity, a trend not observed in patients with rheumatoid arthritis (RA). The study, therefore, presents a new frontier in the investigation of the magnetic characteristics of naturally occurring magnetic cells, opening the door to potential diagnostic and therapeutic applications that leverage cellular magnetism.

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Section: Introductionmentioning

confidence: 99%

Magnetic Characterization of Human Intrinsically Magnetic Monocytes Through a Novel Optical Tracking‐Based Magnetic Sensor

Wu,

Zhang,

Zhao

et al. 2024

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Impact of Static Magnetic Field on In Ovo Angiogenesis and In Vitro Cell Migration

Dini,

Purayil,

Parsanathan

2023

Preprint

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Static magnetic field (SMF) therapy has been proven effective in various tissue repairs. Diamagnetic anisotropy may induce SMF to impact biological macromolecules. The formation of new blood vessels, or angiogenesis, is essential for many pathophysiological processes, including development, reproduction, tumour growth, and metastasis. Inhibiting angiogenesis is one of the key objectives in the fight against cancer and other diseases. The mechanism underlying SMF-mediated regulation of angiogenesis and fibroblast migration is still unclear. Thus, the goal is to investigate the influence of SMF on avian angiogenesis using the chorioallantois membrane (CAM) experiment and murine fibroblast migration. Gallus gallus fertilised eggs were placed in an incubator from day 3 to 7 to the isocentre of the Neodymium Magnet block (30 milli Tesla (mT); North-pole or upward; SMF+) was exposed, and control eggs were placed in a separate incubator (SMF-). On day 7, the angiogenesis or neovascularisation vascular parameters were analysed using a stereoscope and AngioTool. SMF+ stimulation showed a statistically significant decrease in vascular parameters compared to the control. Additionally, the effect of SMF+ on murine fibroblast cell viability, ROS, and migration was explored. Compared to unexposed cells, SMF+ stimulation showed a statistically significant decrease in cellular ROS production and migration after 24 hours without a change in cell viability. These findings imply that SMF could be an effective adjuvant therapy for limiting or preventing excessive ROS, angiogenesis, and fibroblast migration; this effect may be utilised to treat cancer, diabetic retinopathy, and other disorders that entail excessive pathological angiogenesis.

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Static Magnetic Field Direction-Induced Differential Biological Effects

Cited by 2 publications

References 27 publications

Magnetic Characterization of Human Intrinsically Magnetic Monocytes Through a Novel Optical Tracking‐Based Magnetic Sensor

Magnetic Characterization of Human Intrinsically Magnetic Monocytes Through a Novel Optical Tracking‐Based Magnetic Sensor

Impact of Static Magnetic Field on In Ovo Angiogenesis and In Vitro Cell Migration

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