Static magnetic field blocked alprazolam-induced behavior of Wistar rats in the elevated plus-maze test

Brito, Raquel Cardoso; Olivato, Thairyne; Kitabatake, Takae Tamy; Zhang, Kelly; Guirro, Elaine Caldeira de Oliveira; Araújo, João Luiz Vitorino

doi:10.1016/j.neulet.2022.137013

Cited by 3 publications

(2 citation statements)

References 44 publications

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“…In recent studies conducted by Giorgetto et al (2015) and Brito et al (2023), it was demonstrated that MF could interact with and potentiate the effects of drugs that act on the central nervous system. Our study supports this finding by showing the potentiation of the behavioral effects in the RR test of the animals treated with the MF and nAChR agonists (Takeshige & Sato, 1996).…”

Section: Discussionmentioning

confidence: 99%

Effects of Cholinergic Receptor Activation and Magnetic Fields on Motor Behavior in Ischemic Gerbils

Pitta

Zhang

Santo

et al. 2023

Preprint

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Aim of the study: Given the known synergistic relationship between magnetic field (MF) and cholinergic receptor activation in the cholinergic system, the present study aims to investigate whether the combined use of a static MF and an agonist for nicotinic acetylcholine receptors (nAChR) can preserve motor behavior in ischemic gerbils. Materials & methods: We randomly allocated 72 Mongolian gerbils into nine groups (n=8), distributed according to surgical procedure and treatment. The animals were trained and evaluated on the Rotarod (RR) to assess motor performance. Results: Our main finding was the preservation of motor behavior in the Sham Ischemia + Nicotine + Sham Magnetic Stimulation (Sh+N+SMS) and Ischemia + Nicotine + South Pole (I+N+SP) groups, as evidenced by the results of the RR test. Conclusions: Our findings are consistent with previous literature and provide insight into the mechanism of potentiation, as results showed that adding a nAChR agonist to the MF preserved motor performance in the RR test of ischemic animals.

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Section: Discussionmentioning

confidence: 99%

Effects of Cholinergic Receptor Activation and Magnetic Fields on Motor Behavior in Ischemic Gerbils

Pitta

Zhang

Santo

et al. 2023

Preprint

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“…the number of grooming events. [35] Tail-suspension tests assess depression-related behaviors. Animals tend to exhibit an immobile posture when hung by their tails when subject to inescapable stress.…”

Section: Experiments Sectionmentioning

confidence: 99%

Metabolically Glycoengineered Neural Stem Cells Boost Neural Repair After Cardiac Arrest

Du,

Liu,

Marasini

et al. 2023

Adv Funct Materials

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Cardiac arrest (CA)‐induced cerebral ischemia remains challenging with high mortality and disability. Neural stem cell (NSC) engrafting is an emerging therapeutic strategy with considerable promise that, unfortunately, is severely compromised by limited cell functionality after in vivo transplantation. This groundbreaking report demonstrates that metabolic glycoengineering (MGE) using the “Ac5ManNTProp (TProp)” monosaccharide analog stimulates the Wnt/β‐catenin pathway, improves cell adhesion, and enhances neuronal differentiation in human NSCs in vitro thereby substantially increasing the therapeutic potential of these cells. For the first time, MGE significantly enhances NSC efficacy for treating ischemic brain injury after asphyxia CA in rats. In particular, neurological deficit scores and neurobehavioral tests experience greater improvements when the therapeutic cells are pretreated with TProp than with “stand‐alone” NSC therapy. Notably, the TProp‐NSC group exhibits significantly stronger neuroprotective functions including enhanced differentiation, synaptic plasticity, and reduced microglia recruitment; furthermore, Wnt pathway agonists and inhibitors demonstrate a pivotal role for Wnt signaling in the process. These findings help establish MGE as a promising avenue for addressing current limitations associated with NSC transplantation via beneficially influencing neural regeneration and synaptic plasticity, thereby offering enhanced therapeutic options to boost brain recovery following global ischemia.

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Effects of cholinergic receptor activation and magnetic fields on motor behavior in ischemic gerbils

Gallon Pitta,

Zhang,

De Mello Rosa

et al. 2024

Interdisciplinary Rehabilitation / Rehabilitacion Interdiscipli

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Introduction: Ischemic stroke stands as a leading global cause of death and disability, prompting the need for animal model experiments in stroke research and the protection of motor function. Recently, magnetic fields have gained significant interest in various biological contexts, showing promise in preserving neurons and reversing behavioral and morphological changes in stroke models. This study explores the potential synergy between static magnetic field and nAChR agonist administration in safeguarding motor behavior in ischemic gerbils. Objective: To determine whether the combined use of a static magnetic field and an agonist for nicotinic acetylcholine receptors (nAChR) can preserve motor behavior in ischemic gerbils.Methods: In this experimental study, 72 Mongolian gerbils were randomly allocated into nine groups (n=8): S, SISM, SINSM, ISM, INP, ISP, INSM, INNP, INSP, distributed according to surgical procedure and treatment. The animals were trained and evaluated on the Rotarod (RR) to assess motor performance.Results: The main finding was the preservation of motor behavior in the Sham Ischemia and Nicotine and Sham Magnetic Stimulation (SINSM) and Ischemia and Nicotine and South Pole Magnetic Field (INSP) groups, as evidenced by the results of the RR test.Conclusions: The findings are consistent with previous literature and provide insight into the mechanism of potentiation, as results showed that adding a nAChR agonist to the magnetic field preserved motor performance in the RR test of ischemic animals.

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Static magnetic field blocked alprazolam-induced behavior of Wistar rats in the elevated plus-maze test

Cited by 3 publications

References 44 publications

Effects of Cholinergic Receptor Activation and Magnetic Fields on Motor Behavior in Ischemic Gerbils

Effects of Cholinergic Receptor Activation and Magnetic Fields on Motor Behavior in Ischemic Gerbils

Metabolically Glycoengineered Neural Stem Cells Boost Neural Repair After Cardiac Arrest

Effects of cholinergic receptor activation and magnetic fields on motor behavior in ischemic gerbils

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