Static magnetic field attenuates mortality rate of mice by increasing the production of IL-1 receptor antagonist

Abstract

Exposure to an SMF increases the plasma levels of IL-1ra. This effect may inhibit the reduction in PLT in plasma, resulting in prevention in LPS induced DIC.

Static magnetic field attenuates lipopolysaccharide-induced multiple organ failure: A histopathologic study in mice

“…However, an interesting observation from the present study is that body temperature does not increase in response to LPS when mice are pre-exposed to an SMF (Figure 4). Combining this observation with the findings shown in Figure 3 which demonstrate that the LPS-induced mortality rate in mice treated with SMF was significantly reduced, confirmed the results of previous reports that SMF exposure has an attenuating effect on mortality in response to LPS challenge in mice (Lin et al 2009, Shen et al 2014). Since no demonstrable effects of moderate without the LPS-challenge did not increase the thickness of the alveolar wall ( Figure 5b).…”

“…Survival of bacterial infection among patients with MOF is improved by shutting down or controlling the septic response using antiendotoxin therapy (Deitch 1992, Balk 2000, Nguyen et al 2006). Since previous reports indicate that exposure to SMF increases the plasma levels of IL-1ra (Lin et al 2008(Lin et al , 2009), (2014) also proposed that pretreatment with SMF reduced LPS-induced neurodegenerative processes by inhibiting reactive oxygen species-induced neural tissue and neural cell damage.…”

“…Although modifi cations in the release of TNF-α and IL-1 were not detected after SMF treatment (Salerno et al 1999, Aldinucci et al 2003, SMF exposure increased the amount of IL-1ra, resulting in suppression of LPS-induced cytotoxicity in NIH-3T3 cells (Lin et al 2008). A study in mice also demonstrated that the outcome of LPS-induced sepsis could be improved by pre-exposing the mice to a 0.25 T SMF (Lin et al 2009). In 2014, a histological study indicated that SMF pre-exposure had positive eff ects on the pathological outcomes of LPS-treated mice (Shen et al 2014).…”

Daily exposure to inhomogeneous static magnetic field significantly reduces blood glucose level in diabetic mice

“…Moreover, exposure to SMF increased blood glucose and decreased insulin release leading to a diabetic-like state in pregnant rats (Chater et al 2006). The effect of SMF on the survival rate of LPS (lipopoly-saccharide)-induced male BALB/cByJ mice was tested (Lin et al 2009). Mice were exposed to 0.25 T SMF for 2 h before LPS injection.…”

Influence of inhomogeneous static magnetic field-exposure on patients with erosive gastritis: a randomized, self- and placebo-controlled, double-blind, single centre, pilot study

“…Studies with acute peripheral [39], visceral [14] inflammation or even chronic neuropathy [15] showed that SMF-exposure contributes to the machinery of the mammalian body to recover from inflammation. Mice with induced disseminated intravascular coagulation showed lower mortality rate if exposed to SMF [40].…”