One of the problems in a gas turbine's impeller design is to predict the frequency-stress response caused by the harmonic force resulted from the unbalanced mass. To avoid from impeller's flaws that may occur, designers must essentially determine the stress conditions of machinery parts under high-speed rotations. The present research explores, for the first time, the effects of modelling with high entropy alloy materials for an impeller of a gas turbine engine on harmonic responses. In order to conduct harmonic analysis, a finite element model established for an impeller of gas turbine engine by using commercial Ansys finite element package. In the finite element model, the impeller and its shaft modelled by using solid elements and beam elements, respectively. The influence of materials having different high entropy alloys on stress responses is examined for an impeller of a gas turbine engine. The results show that the highest stress exists in AlCoCrFeNi high entropy alloy material for along the sweep frequency range. In addition, the highest stress-percentage ratio is in CoCrFeNi high entropy alloy material for first resonance frequencies. Also, computations illustrate the minimum stress-percentage ratio is in AlCoCrFeMo0.1Ni high entropy alloy material for first resonance frequencies. Another finding is that the maximum percentage ratio is in CoCrFeNi high entropy alloy material for second resonance frequencies. Furthermore, the lowest percentage ratio is detected in AlCoCrFeMo0.1Ni high entropy alloy material for second resonance frequencies.