Static cerebrovascular pressure autoregulation remains intact during deep hypothermia

Goswami, Dheeraj; McLeod, Katherine M.; Leonard, Samantha; Kibler, Kathleen K.; Easley, R. Blaine; Fraser, Charles D.; Andropoulos, Dean B.; Brady, Ken

doi:10.1111/pan.13205

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Physiological Determinants Of Cbf1

Mechanisms Of Hypothermia On Ca1

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2018

2024

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Cited by 4 publications

(2 citation statements)

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“…19 Additionally, application of the technology has revealed that CA is preserved during hypothermia. 20…”

Section: Physiological Determinants Of Cbfmentioning

confidence: 99%

Effects of anesthesia on cerebral blood flow, metabolism, and neuroprotection

Slupe

Kirsch

2018

J Cereb Blood Flow Metab

203

193

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Administration of anesthetic agents fundamentally shifts the responsibility for maintenance of homeostasis from the patient and their intrinsic physiological regulatory mechanisms to the anesthesiologist. Continuous delivery of oxygen and nutrients to the brain is necessary to prevent irreversible injury and arises from a complex series of regulatory mechanisms that ensure uninterrupted cerebral blood flow. Our understanding of these regulatory mechanisms and the effects of anesthetics on them has been driven by the tireless work of pioneers in the field. It is of paramount importance that the anesthesiologist shares this understanding. Herein, we will review the physiological determinants of cerebral blood flow and how delivery of anesthesia impacts these processes.

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“…19 Additionally, application of the technology has revealed that CA is preserved during hypothermia. 20…”

Section: Physiological Determinants Of Cbfmentioning

confidence: 99%

Effects of anesthesia on cerebral blood flow, metabolism, and neuroprotection

Slupe

Kirsch

2018

J Cereb Blood Flow Metab

203

193

View full text Add to dashboard Cite

show abstract

“…Goswami et al. [ 97 ] reported that hypothermic (20°C) piglets retained a static rate of autoregulation that was similar to that of normothermic piglets (0.65 vs. 0.72, P =0.40). The lower limits of autoregulation in hypothermic piglets was slightly lower than that of normothermic piglets (35 mmHg vs. 39 mmHg, P =0.60).…”

Section: Mechanisms Of Hypothermia On Camentioning

confidence: 99%