Keywords: steel frame-composite steel shear wall, dynamic, time-history analysis, Bidirectional ground motions, Three-dimensional space model. Abstract. In order to study the dynamic performance of steel frame-composite steel shear wall structure, a dynamic time-history analysis of a practical hospital buliding was carried out by using FEM software Sap2000. As a comparison, the studies on the building with reinforced concrete shear wall s and steel plate shear wall were also performed. In the FEM model, the factors such as bidirectional ground motions and three-dimensional space were considered. The results indicate that the steel frame-composite steel shear wall structure has higher strength, ample lateral stiffness and better energy dissipation capacity than traditional structures.