Static and dynamic pupillometry data of healthy individuals

Tekin, Kemal; Şekeroğlu, Mehmet Ali; Kızıltoprak, Hasan; Doğuizi, Sibel; İnanç, Merve; Yılmazbaş, Pelin

doi:10.1111/cxo.12659

Cited by 58 publications

(93 citation statements)

References 40 publications

(64 reference statements)

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“…A significant difference between the two groups was observed at ~0.45 s post onset, during the rise time of the pupil dilation response. This pattern replicates parallel observations in the context of the darkness-reflex amplitude (Bitsios et al, 1996;Tekin et al, 2018).…”

Section: Resultssupporting

confidence: 89%

“…Figure 8A plots the median pupil diameter over a 30-second "resting state" measurement session before and after the main experiment. A repeated measures ANOVA on pupil size with timing (pre-or post-the main experiment) as a within-subject measure and age group as between-subject measure revealed a main effect of age group (F(1,34)=22.04, p<.0001), confirming the observation that age is associated with a decreased pupil size (Bitsios et al, 1996;Guillon et al, 2016;Piquado et al, 2010;Tekin et al, 2018;Winn et al, 1994). We also observed a main effect of time (F(1, 34)=10.5, p=.003) with no interaction, confirming that, in both groups, pupil diameter was reduced after the main experiment.…”

Section: Basic Pupil-metricsmentioning

confidence: 52%

“…Specifically, PDR may be instrumental for quantifying deficits in attentive tracking often exhibited by older populations. However, a potential drawback is the known physiological changes to the pupil that occur during healthy ageing; increased demands on accommodation, reduced pupil diameter and slower responses are commonly observed (Bitsios et al, 1996;Guillon et al, 2016;Tekin et al, 2018). Whilst the physiological underpinnings of these effects are not fully clear (Bitsios et al, 1996), they manifest as relative pupil rigidity and may reduce the sensitivity of the PDR as a measure of effort.…”

Section: Experiments 2: Older Listenersmentioning

confidence: 99%

“…There are known changes to pupil reactivity with age (Bitsios et al, 1996;Guillon et al, 2016;Tekin et al, 2018;Winn et al, 1994). These include a smaller resting state diameter, a reduced dilation range, and slower velocity of dilation.…”

Section: Pupil-metrics: Young Vs Older Listenersmentioning

confidence: 99%

“…An objective measure of sustained auditory attention would, therefore, be useful to quantify such difficulties and assess intervention outcomes. However, there are known changes to ocular physiology associated with healthy aging (Bitsios et al, 1996;Guillon et al, 2016;Tekin et al, 2018;Winn et al, 1994) that might limit the efficacy of pupillometry in this population (Piquado et al, 2010;Van Gerven et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Pupillometry as an objective measure of sustained attention in young and older listeners

Zhao

Bury

Milne

et al. 2019

Preprint

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Acknowledgements: supported by funding from the BRC and the EC (Horizon2020 grant to MC). Initial pilot experiments were performed by Youna Cho. We are grateful to Mathilde Le Gal de Kerangal for helping recruit and screen the older listeners in Experiment 2. Data Availability Statement: Upon manuscript acceptance, data will be deposited in a suitable online depository and freely available. AbstractThe ability to sustain attention on a task-relevant sound-source whilst avoiding distraction from other concurrent sounds is fundamental to listening in crowded environments.To isolate this aspect of hearing we designed a paradigm that continuously measured behavioural and pupillometry responses during 25-second-long trials in young (18-35 yo) and older (63-79 yo) participants. The auditory stimuli consisted of a number (1, 2 or 3) of concurrent, spectrally distinct tone streams. On each trial, participants detected brief silent gaps in one of the streams whilst resisting distraction from the others. Behavioural performance demonstrated increasing difficulty with time-on-task and with number/proximity of distractor streams. In young listeners (N=20), pupillometry revealed that pupil diameter (on the group and individual level) was dynamically modulated by instantaneous task difficulty such that periods where behavioural performance revealed a strain on sustained attention, were also accompanied by increased pupil diameter. Only trials on which participants performed successfully were included in the pupillometry analysis. Therefore, the observed effects reflect consequences of task demands as opposed to failure to attend.In line with existing reports, we observed global changes to pupil dynamics in the older group, including decreased pupil diameter, a limited dilation range, and reduced temporal variability. However, despite these changes, the older group showed similar effects of attentive tracking to those observed in the younger listeners. Overall, our results demonstrate that pupillometry can be a reliable and time-sensitive measure of the effort associated with attentive tracking over long durations in both young and (with some caveats) older listeners.

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Section: Resultssupporting

confidence: 89%

Section: Basic Pupil-metricsmentioning

confidence: 52%

Section: Experiments 2: Older Listenersmentioning

confidence: 99%

Section: Pupil-metrics: Young Vs Older Listenersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Pupillometry as an objective measure of sustained attention in young and older listeners

Zhao

Bury

Milne

et al. 2019

Preprint

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Utility of Pupillary Light Reflex Metrics as a Physiologic Biomarker for Adolescent Sport-Related Concussion

et al. 2020

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IMPORTANCE Concussion diagnosis remains clinical, without objective diagnostic tests available for adolescents. Known deficits in visual accommodation and autonomic function after concussion make the pupillary light reflex (PLR) a promising target as an objective physiological biomarker for concussion.OBJECTIVE To determine the potential utility of PLR metrics as physiological biomarkers for concussion.DESIGN, SETTING, AND PARTICIPANTS Prospective cohort of adolescent athletes between ages 12 and 18 years recruited between August 1, 2017, and December 31, 2018. The study took place at a specialty concussion program and private suburban high school and included healthy control individuals (n = 134) and athletes with a diagnosis of sport-related concussion (SRC) (n = 98). Analysis was completed June 30, 2020. EXPOSURES Sports-related concussion and pupillometry assessments.MAIN OUTCOMES AND MEASURES Pupillary light reflex metrics (maximum and minimum pupillary diameter, peak and average constriction/dilation velocity, percentage constriction, and time to 75% pupillary redilation [T75]).RESULTS Pupillary light reflex metrics of 134 healthy control individuals and 98 athletes with concussion were obtained a median of 12.0 days following injury (interquartile range [IQR], 5.0-18.0 days). Eight of 9 metrics were significantly greater among athletes with concussion after Bonferroni correction (maximum pupil diameter: 4.83 mm vs 4.

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Extended depth-of-focus (EDOF) AcrySof® IQ Vivity® intraocular lens implant: a real-life experience

Arrigo

Gambaro

Fasce

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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Static and dynamic pupillometry data of healthy individuals

Abstract: The current study presents population-specific normative data on static and dynamic pupillometry values in different age groups and the effect of age on pupillary characteristics.

Cited by 58 publications

References 40 publications

Pupillometry as an objective measure of sustained attention in young and older listeners

Pupillometry as an objective measure of sustained attention in young and older listeners

Utility of Pupillary Light Reflex Metrics as a Physiologic Biomarker for Adolescent Sport-Related Concussion

Extended depth-of-focus (EDOF) AcrySof® IQ Vivity® intraocular lens implant: a real-life experience

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