Static and dynamic aspects of cerebro-cerebellar functional connectivity are associated with self-reported measures of impulsivity: A resting-state fMRI study

Abdallah, Majd; Farrugia, Nicolas; Chirokoff, Valentine; Chanraud, Sandra

doi:10.1162/netn_a_00149

Cited by 10 publications

(5 citation statements)

References 67 publications

(93 reference statements)

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“…Intracranial electric stimulation studies in animals reported that stimulation of the vermis dampens impulsive aggressive responses [ 24 ], arguably through Purkinje cell-related inhibition of the forebrain [ 23 ]. In addition, the presence of structural pathways between the cerebellum and reward-sensitive brain areas such as the basal ganglia [ 71 , 72 ] has recently been complemented by research showing functional connectivity between the vermis and basal ganglia [ 73 , 74 ]. It was found that stronger signal dependency between these areas was associated with lower levels of impulsivity [ 73 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the presence of structural pathways between the cerebellum and reward-sensitive brain areas such as the basal ganglia [ 71 , 72 ] has recently been complemented by research showing functional connectivity between the vermis and basal ganglia [ 73 , 74 ]. It was found that stronger signal dependency between these areas was associated with lower levels of impulsivity [ 73 ]. The anatomical and functional relationship between the vermis, basal ganglia, and forebrain suggests an active contribution of the vermis to approach- and reward-related action tendencies [ 75 ] and impulse control [ 76 ].…”

Section: Discussionmentioning

confidence: 99%

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Cerebellar Grey Matter Volumes in Reactive Aggression and Impulsivity in Healthy Volunteers

2022

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Several lines of evidence point towards the involvement of the cerebellum in reactive aggression. In addition to the posterior cerebellar hemisphere, the vermis has been suggested to play a prominent role in impulse regulation. In the present study, we set out to further examine the relationships between cerebellar grey matter volumes, aggression, and impulsivity in 201 healthy volunteers. 3 T structural magnetic resonance imaging scans were acquired to investigate grey matter volumes of the cerebellar vermis and the anterior and posterior lobules. Aggression was assessed with the Buss–Perry Aggression Questionnaire and impulsivity was measured with the Barratt Impulsiveness Scale-11. Results showed that impulsivity was positively associated with grey matter volumes of the cerebellar vermis and inversely correlated with grey matter volumes of the right posterior lobule. In addition, smaller volumes of the right posterior lobules were associated with higher physical aggression. Exploratory analyses indicated that for the right hemisphere, this association was driven by grey matter volumes of lobules VIIb and VIIIa. Our findings provide correlational evidence in healthy volunteers for the involvement of the cerebellar vermis and posterior lobules in a cortico-limbic-cerebellar circuit of aggression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cerebellar Grey Matter Volumes in Reactive Aggression and Impulsivity in Healthy Volunteers

2022

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“…It is worth noting that very few studies have used multiple methodologies (e.g., chronic headache [ 34 ], disorders of consciousness [DOCs] [ 35 ]). Similarly, in cognitive and behavioral applications, some studies have used sliding-window and clustering methods (e.g., task prediction [ 22 ], cognitive and behavioral flexibility [ 36 ]), some have used coactivation patterns (CAP) analysis (e.g., naturalistic stimuli [ 37 ], multiple tasks [ 38 ]) and HMM (e.g., sleep stage [ 39 ], impulsivity [ 40 ]), and very few have used multiple methods (e.g., working memory task [ 41 ]). A complete list of the reviewed studies can be found in Supplementary Tables S1 , S2 , and S3 .…”

Section: Introductionmentioning

confidence: 99%

On the variability of dynamic functional connectivity assessment methods

Torabi,

Mitsis,

Poline

2024

GigaScience

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Background Dynamic functional connectivity (dFC) has become an important measure for understanding brain function and as a potential biomarker. However, various methodologies have been developed for assessing dFC, and it is unclear how the choice of method affects the results. In this work, we aimed to study the results variability of commonly used dFC methods. Methods We implemented 7 dFC assessment methods in Python and used them to analyze the functional magnetic resonance imaging data of 395 subjects from the Human Connectome Project. We measured the similarity of dFC results yielded by different methods using several metrics to quantify overall, temporal, spatial, and intersubject similarity. Results Our results showed a range of weak to strong similarity between the results of different methods, indicating considerable overall variability. Somewhat surprisingly, the observed variability in dFC estimates was found to be comparable to the expected functional connectivity variation over time, emphasizing the impact of methodological choices on the final results. Our findings revealed 3 distinct groups of methods with significant intergroup variability, each exhibiting distinct assumptions and advantages. Conclusions Overall, our findings shed light on the impact of dFC assessment analytical flexibility and highlight the need for multianalysis approaches and careful method selection to capture the full range of dFC variation. They also emphasize the importance of distinguishing neural-driven dFC variations from physiological confounds and developing validation frameworks under a known ground truth. To facilitate such investigations, we provide an open-source Python toolbox, PydFC, which facilitates multianalysis dFC assessment, with the goal of enhancing the reliability and interpretability of dFC studies.

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“…Such dynamic FC analyses promise a deeper understanding of dynamic interactions of brain regions within and across these functional networks [ 15 – 17 ] in health and disease. Dynamic FC measures have been associated with differences in individual attentional performance [ 18 , 19 ] and impulsivity [ 20 , 21 ]. For example, altered FC dynamics have been observed in participants with attention deficit hyperactivity disorder (ADHD) [ 22 – 24 ].…”

Section: Introductionmentioning

confidence: 99%

Functional connectivity of cognition-related brain networks in adults with fetal alcohol syndrome

Sundermann,

Feldmann,

Mathys

et al. 2023

BMC Med

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Background Fetal alcohol syndrome (FAS) can result in cognitive dysfunction. Cognitive functions affected are subserved by few functional brain networks. Functional connectivity (FC) in these networks can be assessed with resting-state functional MRI (rs-fMRI). Alterations of FC have been reported in children and adolescents prenatally exposed to alcohol. Previous reports varied substantially regarding the exact nature of findings. The purpose of this study was to assess FC of cognition-related networks in young adults with FAS. Methods Cross-sectional rs-fMRI study in participants with FAS (n = 39, age: 20.9 ± 3.4 years) and healthy participants without prenatal alcohol exposure (n = 44, age: 22.2 ± 3.4 years). FC was calculated as correlation between cortical regions in ten cognition-related sub-networks. Subsequent modelling of overall FC was based on linear models comparing FC between FAS and controls. Results were subjected to a hierarchical statistical testing approach, first determining whether there is any alteration of FC in FAS in the full cognitive connectome, subsequently resolving these findings to the level of either FC within each network or between networks based on the Higher Criticism (HC) approach for detecting rare and weak effects in high-dimensional data. Finally, group differences in single connections were assessed using conventional multiple-comparison correction. In an additional exploratory analysis, dynamic FC states were assessed. Results Comparing FAS participants with controls, we observed altered FC of cognition-related brain regions globally, within 7 out of 10 networks, and between networks employing the HC statistic. This was most obvious in attention-related network components. Findings also spanned across subcomponents of the fronto-parietal control and default mode networks. None of the single FC alterations within these networks yielded statistical significance in the conventional high-resolution analysis. The exploratory time-resolved FC analysis did not show significant group differences of dynamic FC states. Conclusions FC in cognition-related networks was altered in adults with FAS. Effects were widely distributed across networks, potentially reflecting the diversity of cognitive deficits in FAS. However, no altered single connections could be determined in the most detailed analysis level. Findings were pronounced in networks in line with attentional deficits previously reported.

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Static and dynamic aspects of cerebro-cerebellar functional connectivity are associated with self-reported measures of impulsivity: A resting-state fMRI study

Cited by 10 publications

References 67 publications

Cerebellar Grey Matter Volumes in Reactive Aggression and Impulsivity in Healthy Volunteers

Cerebellar Grey Matter Volumes in Reactive Aggression and Impulsivity in Healthy Volunteers

On the variability of dynamic functional connectivity assessment methods

Functional connectivity of cognition-related brain networks in adults with fetal alcohol syndrome

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