Statements from the Taormina expert meeting on occult hepatitis B virus infection

Raimondo, Giovanni; Allain, Jean Pierre; Brunetto, Maurizia Rossana; Buendia, Marie Annick; Chen, Ding‐Shinn; Colombo, Massimo; Craxı̀, Antonio; Donato, Francesco; Ferrari, Carlo; Gaeta, Giovanni Battista; Gerlich, Wolfram H.; Levrero, Massimo; Locarnini, Stephen; Michalak, T.I.; Mondelli, Mario U.; Pawlotsky, Jean‐Michel; Pollicino, Teresa; Prati, Daniele; Puoti, Massimo; Samuel, Didier; Shouval, Daniel; Smedile, Antonina; Squadrito, Giovanni; Trépo, C.; Villa, Erica; Will, Hans; Zanetti, Alessandro; Zoulim, Fabien

doi:10.1016/j.jhep.2008.07.014

Cited by 715 publications

(873 citation statements)

References 55 publications

(77 reference statements)

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“…Besides the decreasing impact of HCV, we found a doubling of HCCs negative for hepatitis virus markers (from 12.1% to 23.7%), which was recorded even in younger patients. An alcohol abuse was the backbone for liver disease progression in most of these patients, since 91.9% reported a daily intake of >4 drinks; in some patients, HBV occult infection might have played a contributory role, as suggested by the presence of anti-HBc antibodies [18]. We could not evaluate the role of metabolic syndrome, an emerging major risk (co)factor for HCC in developing countries [19,20].…”

Section: Discussionmentioning

confidence: 94%

Changing aetiological factors of hepatocellular carcinoma and their potential impact on the effectiveness of surveillance

Stroffolini

Trevisani

Pinzello

et al. 2011

Digestive and Liver Disease

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a b s t r a c tBackground: The aetiological factors of hepatocellular carcinoma may vary over time. Aims: The study assessed the potential impact of the aetiological factors on the effectiveness of surveillance in real-world patients. Methods: Multicentre, cross-sectional study enrolling consecutive hepatocellular carcinoma cases during a six month period. Results: 1733 cases (1311 prevalent and 422 incident) were recruited (mean age 68.6 years; 46.1% cases over 70 years; 73.9% males; 95.3% with cirrhosis); 63.0% were hepatitis C virus positive and 23.7% were virus negative. Amongst incident HCCs, 34.5% were single ≤3 cm and 54.4% met the Milan criteria; 61.6% were diagnosed during surveillance; virus negative patients showed the lowest rate of surveillance (51.0%). Surveillance was an independent predictor of detecting single HCCs ≤2 cm (O.R. = 5.4; 95% C.I. = 2.4-12.4) or HCCs meeting the Milan criteria (O.R. = 3.1; 95% C.I. = 1.9-5.2). Compared with an earlier Italian survey, there was a higher proportion of elderly subjects (P < 0.01), Child-Pugh class A cases (P < 0.01), of virus-negative patients (P < 0.01) and with single tumours ≤3 cm (P < 0.01) and a lower prevalence of hepatitis C virus positive individuals (P < 0.01). Conclusion: HCC is characterised by a growing prevalence of elderly patients and cases unrelated to hepatitis virus infections. The application of surveillance must be implemented, particularly amongst non-viral patients.

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Section: Discussionmentioning

confidence: 94%

Changing aetiological factors of hepatocellular carcinoma and their potential impact on the effectiveness of surveillance

Stroffolini

Trevisani

Pinzello

et al. 2011

Digestive and Liver Disease

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“…Occult HBV infection is defined as persistence of B virus genomes in HBsAg-negative individuals. 70 This condition is more frequent (almost 10% in some series 6 ) in patients with HBV markers (anti-HBc with or without anti-HBs). Thus, although AASLD guidelines recommend screening for HBsAg and anti-HBs, screening for anti-HBc has also been recommended to detect occult HBV.…”

Section: How Frequent Is Progression To Liver Cirrhosis In Ibd Patienmentioning

confidence: 99%

Review article: prevention and management of hepatitis B and C infection in patients with inflammatory bowel disease

Gisbert

Chaparro

Esteve

2011

Alimentary Pharmacology &Amp; Therapeutics

101

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“…Approximately one third of the world's population has been infected with HBV . While chronic HBV infection is diagnosed by the presence of the hepatitis B surface antigen (HBsAg) and HBV DNA in patient serum, occult hepatitis B (OHB) is diagnosed by testing negative for HBsAg in serum, presence of HBV DNA in the liver and maintaining very low HBV DNA in the serum (Raimondo et al 2008, Hollinger & Sood 2010. OHB infection may be further stratified by HBV antibody profiles into seropositive and seronegative categories.…”

mentioning

confidence: 99%

Multiple cytokine expression profiles reveal immune-based differences in occult hepatitis B genotype H-infected Mexican Nahua patients

Fierro¹,

Román²,

Realpe³

et al. 2011

Mem. Inst. Oswaldo Cruz

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A high prevalence of occult hepatitis B (OHB) genotype H infections has been observed in the native Mexican Nahua population. In addition, a low incidence of hepatitis B virus (HBV)-associated hepatocellular carcinoma has been described in Mexico. The immune response to infection among OHB-infected patients has been poorly evaluated in vivo. Therefore, we assessed the expression profiles of 23 cytokines in OHB genotype H-infected Nahua patients. A total of 41 sera samples from natives of the Nahua community were retrospectively analysed. Based on their HBV antibody profiles, patients were stratified into two groups: OHB patients (n = 21) and patients that had recovered from HBV infection (n = 20). Herein, we report distinctive cytokines profiles in OHB-infected individuals. Compared to healthy controls (n = 20) and patients who resolved HBV infection, OHB-infected patients displayed an increase in interleukin (IL)-2 secretion in addition to a characteristic inflammation profile (decrease in IL-8 and tumour necrosis factor-alpha levels and increased levels of tumour growth factor-beta). IL-15 and interferon-gamma levels were reduced in OHB-infected individuals when compared to those patients who resolved HBV infection. In contrast, OHB patients showed an increase in monocyte chemoattractant protein (MCP)-1 and MCP-2 compared to healthy controls and patients who resolved HBV infection. These findings suggest that cytokine expression can influence the severity of OHB disease and could lead to new investigation into the treatment of liver and other infectious diseases

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Statements from the Taormina expert meeting on occult hepatitis B virus infection

Cited by 715 publications

References 55 publications

Changing aetiological factors of hepatocellular carcinoma and their potential impact on the effectiveness of surveillance

Changing aetiological factors of hepatocellular carcinoma and their potential impact on the effectiveness of surveillance

Review article: prevention and management of hepatitis B and C infection in patients with inflammatory bowel disease

Multiple cytokine expression profiles reveal immune-based differences in occult hepatitis B genotype H-infected Mexican Nahua patients

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