Statement of Retraction

Pacurari, Maricica; Qian, Y; Fu, Wei; Schwegler‐Berry, Diane; Ding, Min; Castranova, Vincent; Guo, N L

doi:10.1080/15287394.2012.625549

Cited by 23 publications

(18 citation statements)

References 58 publications

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“…The reasons for increased permeability include higher levels of ROS and reconstitution of actin filaments, with possible involvement of MCP-1 and ICAM-1. 327 Further research reflecting these findings in vivo is expected.…”

Section: Present Status Of Research Into the In Vivo Toxicity Of Cntsmentioning

confidence: 86%

“…327 As compared to CNTs particles (that are fibrous), carbon black particles (that are spherical) migrate more readily between tissues and the bloodstream. However, a reference is not needed to track the in vivo migration of CNTs.…”

Section: Discussion and Perspectivementioning

confidence: 99%

“…However, this decision requires extremely careful consideration. 327 As of 2012, the EC had approved 20 nanopharmaceuticals (of course, other than CNTs). 301 Although drug delivery and whole-body imaging using CNTs are highly effective procedures, major risk arises from their systemic circulation via the bloodstream.…”

Section: Discussion and Perspectivementioning

confidence: 99%

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Safe Clinical Use of Carbon Nanotubes as Innovative Biomaterials

et al. 2014

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Section: Present Status Of Research Into the In Vivo Toxicity Of Cntsmentioning

confidence: 86%

Section: Discussion and Perspectivementioning

confidence: 99%

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Safe Clinical Use of Carbon Nanotubes as Innovative Biomaterials

et al. 2014

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“…Alterations in membrane permeability due to pulmonary inflammation can lead to particle distribution extending beyond the lung (Zhu et al, 2009). MWCNT exposure increases the permeability of microvascular endothelium via increased cell migration, reactive oxygen species (ROS) response and actin remodeling (Pacurari et al, 2012). Further investigations of the biodistribution and pharmacokinetics of CNTs are essential in understanding their toxicities.…”

Section: Biodistribution Of Cntsmentioning

confidence: 99%

Pulmonary toxicity and fibrogenic response of carbon nanotubes

Manke

Wang

Rojanasakul

2013

Toxicology Mechanisms and Methods

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Carbon nanotubes (CNTs) have been a subject of intensive research for a wide range of applications. However, because of their extremely small size and light weight, CNTs are readily inhaled into human lungs resulting in increased rates of pulmonary disorders, most notably fibrosis. Several studies have demonstrated the fibrogenic effects of CNTs given their ability to translocate into the surrounding areas in the lung causing granulomatous lesions and interstitial and sub-pleural fibrosis. However, the mechanisms underlying the disease process remain obscure due to the lack of understanding of the cellular interactions and molecular targets involved. Interestingly, certain physicochemical properties of CNTs have been shown to affect their respiratory toxicity, thereby becoming significant determinants of fibrogenesis. CNT-induced fibrosis involves a multitude of cell types and is characterized by the early onset of inflammation, oxidative stress and accumulation of extracellular matrix. Increased reactive oxygen species activate various cytokine/growth factor signaling cascades resulting in increased expression of inflammatory and fibrotic genes. Profibrotic growth factors and cytokines contribute directly to fibroblast proliferation and collagen production. Given the role of multiple players during the pathogenesis of CNT-induced fibrosis, the objective of this review is to summarize the key findings and discuss major cellular and molecular events governing pulmonary fibrosis. We also discuss the physicochemical properties of CNTs and their effects on pulmonary toxicities as well as various biological factors contributing to the development of fibrosis.

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“…Thus in aggregate these data suggest that the rho kinase signaling was not a primary mechanism responsible for augmented stress generation observed following MWCNT exposure. Other mechanisms postulated to enhance force generation can include generation of reactive oxygen species [49], increased oxidative stress [50] and enhanced cyclooxygenase signaling [51]. SWCNTs have shown to increase oxidative stress and alter the mitochondrial signaling following intrapharyngeal instillation [52].…”

Section: Discussionmentioning

confidence: 99%

Vascular Tissue Contractility Changes Following Late Gestational Exposure to Multi-Walled Carbon Nanotubes or their Dispersing Vehicle in Sprague Dawley Rats

Vidanapathirana

Thompson

Odom

et al. 2014

J Nanomed Nanotechnol

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Multi-walled carbon nanotubes (MWCNTs) are increasingly used in industry and in nanomedicine raising safety concerns, especially during unique life-stages such as pregnancy. We hypothesized that MWCNT exposure during pregnancy will increase vascular tissue contractile responses by increasing Rho kinase signaling. Pregnant (17–19 gestational days) and non-pregnant Sprague Dawley rats were exposed to 100 μg/kg of MWCNTs by intratracheal instillation or intravenous administration. Vasoactive responses of uterine, mesenteric, aortic and umbilical vessels were studied 24 hours post-exposure by wire myography. The contractile responses of the vessel segments were different between the pregnant and non-pregnant rats, following MWCNT exposure. Maximum stress generation in the uterine artery segments from the pregnant rats following pulmonary MWCNT exposure was increased in response to angiotensin II by 4.9 mN/mm2 (+118%), as compared to the naïve response and by 2.6 mN/mm2 (+40.7%) as compared to the vehicle exposed group. Following MWCNT exposure, serotonin induced approximately 4 mN/mm2 increase in stress generation of the mesenteric artery from both pregnant and non-pregnant rats as compared to the vehicle response. A significant contribution of the dispersion medium was identified as inducing changes in the contractile properties following both pulmonary and intravenous exposure to MWCNTs. Wire myographic studies in the presence of a Rho kinase inhibitor and RhoA and Rho kinase mRNA/protein expression of rat aortic endothelial cells were unaltered following exposure to MWCNTs, suggesting absent/minimal contribution of Rho kinase to the enhanced contractile responses following MWCNT exposure. The reactivity of the umbilical vein was not changed; however, mean fetal weight gain was reduced with dispersion media and MWCNT exposure by both routes. These results suggest a susceptibility of the vasculature during gestation to MWCNT and their dispersion media-induced vasoconstriction, predisposing reduced fetal growth during pregnancy.

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Statement of Retraction

Cited by 23 publications

References 58 publications

Safe Clinical Use of Carbon Nanotubes as Innovative Biomaterials

Safe Clinical Use of Carbon Nanotubes as Innovative Biomaterials

Pulmonary toxicity and fibrogenic response of carbon nanotubes

Vascular Tissue Contractility Changes Following Late Gestational Exposure to Multi-Walled Carbon Nanotubes or their Dispersing Vehicle in Sprague Dawley Rats

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