State of the retinal and vascular membranes of the rabbit eye with diabetes mellitus modeled by Dithizone. Report 1. Structural changes

Abstract

Recently questions on the central thickness of cornea (CTC) and its role in the risk of development and progression of primary open-angle glaucoma have been discussed in the Ukrainian and foreign publications. Little attention is paid to a question of taking into account paracentral and peripheral thicknesses of the cornea (PcTC and PTC) during the estimation of the rate of progression of POAG in the long-term follow-ups.The article presents a study of the three basic zones of the cornea (CTC, PcTC and PTC) as a possibility of their influence on the rate of POAG progression in patients with the long-term follow-up. As a result of the investigation there was revealed the substantial difference of PTC index between the groups of patients with a different rate of the POAG progression. The index of PcTC also revealed these differences but at the considerably smaller level than the previous one. The index CTC practically did not reveal the difference between the different groups of patients. The high difference in the cornea thickness in separate segments (lower, lower, temporal and temporal -lower) between all groups of patients was also revealed. The degree of differences in the indices of the measured zones and the separate segments was highest between the groups with slowly and rapidly progressing POAG and smallest between the groups with the average and rapid rate of progression of the pathologic process. ÑÎÑÒÎßÍÈÅ ÑÅÒ×ÀÒÎÉ È ÑÎÑÓÄÈÑÒÎÉ ÎÁÎËÎ×ÅÊ ÃËÀÇÀÊÐÎËÈÊÀ Ñ ÑÀÕÀÐÍÛÌ ÄÈÀÁÅÒÎÌ, ÌÎÄÅËÈÐÎÂÀÍÍÛÌ ÄÈÒÈÇÎÍÎÌ. ÑÎÎÁÙÅÍÈÅ 1. ÑÒÐÓÊÒÓÐÍÛÅ ÈÇÌÅÍÅÍÈß Ý. Â. Ìàëüöåâ, ïðîô., À. Â. Çáîðîâñêàÿ, ê. ì. í., À. Ý. Äîðîõîâà, âðà÷. ÃÓ «Èíñòèòóò ãëàçíûõ áîëåçíåé è òêàíåâîé òåðàïèè ÍÀÌÍ Óêðàèíû» Ó êðîëèê³â ç öóêðîâèì ä³àáåòîì, ÿêèé ìîäåëþâàëè çà äîïîìîãîþ äèòèçîíó â äîç³ 35 ìã/êã, ðîçâèâàþòüñÿ îçíàêè ä³àáåòè÷íî¿ ðåòèíîïàò³¿. Ïðè öüîìó â ñ³òê³âö³ ÷åðåç 6-7 ãîäèí (ôàçà ã³ïîãë³êå쳿) òà 33-36 ãîäèí (ïî÷àòîê ôàçè âòîðèííî¿ ñò³éêî¿ ôàçè ã³ïîãë³êå쳿) ï³ñëÿ ââåäåííÿ äèòèçîíó ã³ñòîëîã³÷í³ îçíàêè ¿¿ ïîøêîäaeåííÿ â³äñóòí³, àëå ÷åðåç 16-17 òèaeí³â íà òë³ ðîçâèíóòîãî ä³àáåòà âîíè âaeå çíà÷íî âèðàaeåí³. Ñïîñòåð³ãàºòüñÿ äåñòðóêö³ÿ øàð³â ôîòîðåöåïòîð³â ³ ï³ãìåíòíîãî åï³òåë³þ, íåéðîíè çîâí³øíüîãî òà âíóòð³øíüîãî ÿäåðíèõ øàð³â âíàñë³äîê ÷àñòêîâî¿ â³äñóòíîñò³ ñ³ò÷àñòîãî øàðó ïåðåì³ùóþòüñÿ, à çíà÷íà ¿õ ÷àñòèíà ãèíå, ÿê ³ äåÿê³ ãàíãë³îçí³ êë³òèíè. Îçíàêè àòðîô³¿, îêð³ì ñ³òê³âêè, âèÿâëÿþòüñÿ òàêîae ³ â ñóäèíí³é îáîëîíö³. Íàâåäåíà ìîäåëü ä³à-áåòè÷íî¿ ðåòèíîïàò³¿ äîáðå â³äîáðàaeóº ¿¿ ïðèðîäó ÿê íåéðîäåãåíåðàòèâíîãî çàõâîðþâàííÿ. Êëþ÷åâûå ñëîâà: äèàáåòè÷åñêàÿ ðåòèíîïàòèÿ, ñåò÷àòàÿ îáîëî÷êà, ñîñóäèñòàÿ îáîëî÷êà, ñòðóêòóðíûå èçìåíåíèÿ, äèòèçîíîâûé äèàáåò.