State-of-the-art review: stress T1 mapping—technical considerations, pitfalls and emerging clinical applications

Piechnik, Stefan K.; Neubauer, Stefan; Ferreira, Vanessa M.

doi:10.1007/s10334-017-0649-5

Cited by 45 publications

(58 citation statements)

References 61 publications

(115 reference statements)

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“…Table 2 summarizes currently available normal ranges of myocardial T1 stress reactivity. Although residual heart rate dependency of applied MOLLI protocols might have reduce measured myocardial T1 stress reactivity compared to a "true", heart rate independent one [24,77], all tabulated myocardial T1 stress reactivities substantially exceeded intra-scan reproducibilities of regional T1 measurements of approximately 2% [84]. The age and gender dependence of the nevertheless small values, and the impact of sequence, evaluation and pharmacological stress technique on the normal ranges, are, however, topics of current research [77].…”

Section: Stress T1 Mappingmentioning

confidence: 93%

“…Pharmacological vasodilator stress induced by adenosine or regadenosone is a common CMR procedure to study myocardial perfusion reserve via dynamic contrast enhancement [76]. Along with the change of myocardial blood flow, vasodilator stress also increases, at least under normal conditions, myocardial blood volume [77], which in turn increases native myocardial T1 times due to partial volume averaging with high T1 times of blood (Fig. 11).…”

Section: Stress T1 Mappingmentioning

confidence: 99%

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Cardiac magnetic resonance T1 mapping. Part 1: Aspects of acquisition and evaluation

Reiter

Kräuter

et al. 2018

European Journal of Radiology

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While an enormous number of studies have documented pathological alterations of the myocardial native longitudinal relaxation time (T1) and the fraction of the extracellular myocardial volume (ECV), it has also become clear that continuously evolving T1 mapping sequence, acquisition and evaluation techniques have a substantial impact on quantitative results, making the translation of reported findings into routine clinical use particularly challenging. To provide a basis for the discussion of pathological myocardial T1 and ECV alterations, the present review aims to summarize the methodological aspects of myocardial T1 mapping along with technical and physiological factors influencing results and normal ranges of myocardial native T1 and ECV reported across studies. 2. Sequences and protocols Numerous techniques have been introduced for the generation of cardiac T1 maps [11-22], each of which possesses specific advantages and disadvantages with respect to acquisition time, spatial resolution, accuracy (systematic bias of estimated T1 compared to true T1), and

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Section: Stress T1 Mappingmentioning

confidence: 93%

Section: Stress T1 Mappingmentioning

confidence: 99%

Cardiac magnetic resonance T1 mapping. Part 1: Aspects of acquisition and evaluation

Reiter

Kräuter

et al. 2018

European Journal of Radiology

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“…Therefore, due to the increased volume of myocardial blood, the T1 relaxation time is already prolonged at rest and does not change under stress conditions. [89][90][91] Another innovative noncontrast approach is the CMR blood oxygen level-dependent method, which uses the paramagnetic features of deoxyhemoglobin. An increased amount of this endogenous contrast agent results in signal reduction on T2*-weighted images and therefore indicates the myocardial oxygenation status during rest and vasodilator stress.…”

Section: % 100%mentioning

confidence: 99%

Cardiac magnetic resonance imaging to detect ischemia in chronic coronary syndromes: state of the art

Sokolska¹,

Spiczak²,

Gotschy³

et al. 2019

Kardiol Pol

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The new 2019 European Society of Cardiology guidelines for the diagnosis and management of chronic coronary syndromes emphasize the role of noninvasive functional imaging of myocardial ischemia in diagnosing coronary artery disease to guide decision making regarding revascularization. Cardiac magnetic resonance imaging (CMR) stands out relative to other imaging modalities given its high safety profile, absence of ionizing radiation, and its versatility in encoding various image contrasts. It also allows an assessment of myocardial function, ischemia, and viability as well as permits tissue characterization including detection of edema in a single examination. In recent years, a number of meta-analyses and studies considering the role of CMR for detecting ischemia have been published. The recent multicenter randomized MR-INFORM trial has demonstrated the clinical utility of CMR in patients with stable angina and cardiovascular risk factors. This landmark study has proved that a perfusion CMR-based strategy leads to a lower number of revascularizations while being noninferior to an invasive coronary angiography with fractional flow reserve-guided therapy in terms of major adverse cardiac events at 1 year. In light of recent and future technical improvements, CMR will become increasingly important in the assessment of myocardial ischemia in patients with chronic coronary syndromes.

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“…Not only do native rest-to-stress T1 values have diagnostic potential, but a negative myocardial T1 rest-to-stress response was observed in subjects with short-term caffeine intake [27,28], which could serve as a pre-test for adequate vasodilatory stress before contrast agent application in stress perfusion imaging. As normal myocardial T1 restto-stress increases differ (see part 1 of this review (doi: 10.1016/ j.ejrad.2018.10.011)), definition of site-specific normal ranges is inevitable [29]. In contrast to the standardized CMR protocols for assessment of CAD and myocardial infarction, the diagnosis of stress-induced Tako-Tsubo cardiomyopathy (CMP) is challenging, especially if scheduling of CMR imaging is delayed in the course of the diagnostic workup.…”

Section: Ischemic and Stress-induced Myocardial Diseasesmentioning

confidence: 99%

Cardiac magnetic resonance T1 mapping. Part 2: Diagnostic potential and applications

Reiter

Kräuter

et al. 2018

European Journal of Radiology

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Non-invasive identification and differentiation of myocardial diseases represents the primary objectives of cardiac magnetic resonance (CMR) longitudinal relaxation time (T1) and extracellular volume (ECV) mapping. Given the fact that myocardial T1 and ECV values overlap throughout and within left ventricular phenotypes, a central issue to be addressed is whether and to what extent myocardial T1 and ECV mapping provides additional or superior diagnostic information to standard CMR imaging, and whether native T1 mapping could be employed as a non-contrast alternative to late gadolinium enhancement (LE) imaging. The present review aims to summarize physiological and pathophysiological alterations in native T1 and ECV values and summarized myocardial T1 and ECV alterations associated with cardiac diseases to support the translation of research findings into routine CMR imaging.

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State-of-the-art review: stress T1 mapping—technical considerations, pitfalls and emerging clinical applications

Cited by 45 publications

References 61 publications

Cardiac magnetic resonance T1 mapping. Part 1: Aspects of acquisition and evaluation

Cardiac magnetic resonance T1 mapping. Part 1: Aspects of acquisition and evaluation

Cardiac magnetic resonance imaging to detect ischemia in chronic coronary syndromes: state of the art

Cardiac magnetic resonance T1 mapping. Part 2: Diagnostic potential and applications

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