State-of-the-art review of the application and development of various methods of aerosol therapy

Matuszak, Magdalena; Ochowiak, Marek; Włodarczak, Sylwia; Krupińska, Andżelika; Doligalski, Michał

doi:10.1016/j.ijpharm.2021.121432

Cited by 9 publications

(7 citation statements)

References 286 publications

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“…Aerosols are considered to be a superior way to manage all lung diseases because of their advantages of rapid effect, lower dose, higher lung dose and lower systemic effects. 33 , 34 Nebulizers are the primary device for generating aerosols and are widely used in both home and hospital settings, including during mechanical ventilation, during noninvasive ventilation and during high-flow nasal cannula, and they are also useful for pediatric, geriatric, and unconscious patients. 35 The amount of drug delivered by nebulizers varies widely, and physiological factors such as breathing pattern and airway diameter depend on the type of disease and can affect the efficiency of drug delivery.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Application of Vibrating Mesh Nebulizer and Jet Nebulizer in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta‐analysis

Feng,

Han,

Wang

et al. 2024

COPD

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Objective To comparison of the application of Vibrating Mesh Nebulizer and Jet Nebulizer in chronic obstructive pulmonary disease (COPD). Research Methods This systematic review and meta-analysis was conducted following the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) statements. The primary outcome measures analyzed included: The amount of inhaler in the urine sample at 30 minutes after inhalation therapy (USAL0.5), The total amount of inhaler in urine sample within 24 hours (USAL24), Aerosol emitted, Forced expiratory volume in 1 second (FEV 1 ), Forced vital capacity (FVC). Results Ten studies were included with a total of 314 study participants, including 157 subjects in the VMN group and 157 subjects in the JN group. The data analysis results of USAL0.5, MD (1.88 [95% CI, 0.95 to 2.81], P = 0.000), showed a statistically significant difference. USAL24, MD (1.61 [95% CI, 1.14 to 2.09], P = 0.000), showed a statistically significant difference. The results of aerosol emitted showed a statistically significant difference in MD (3.44 [95% CI, 2.84 to 4.04], P = 0.000). The results of FEV 1 showed MD (0.05 [95% CI, −0.24 to 0.35], P=0.716), the results were not statistically significant. The results of FVC showed MD (0.11 [95% CI, −0.18 to 0.41], P=0.459), the results were not statistically significant. It suggests that VMN is better than JN and provides higher aerosols, but there is no difference in improving lung function between them. Conclusion VMN is significantly better than JN in terms of drug delivery and utilization in the treatment of patients with COPD. However, in the future use of nebulizers, it is important to select a matching nebulizer based on a combination of factors such as mechanism of action of the nebulizer, disease type and comorbidities, ventilation strategies and modes, drug formulations, as well as cost-effectiveness, in order to achieve the ideal treatment of COPD.

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Section: Discussionmentioning

confidence: 99%

Comparison of the Application of Vibrating Mesh Nebulizer and Jet Nebulizer in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta‐analysis

Feng,

Han,

Wang

et al. 2024

COPD

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“…Another drawback in LDH agglomeration/aggregation is their inappropriate use as drug carriers, especially for aerosol therapy. [55][56][57] Among the prerequisites for drug delivery by aerosol therapy is good particle dispersion, which should be managed with a narrow and stable particle size distribution of the unit/primary particles, and is more challenging in this type of application. Poor particle dispersion hinders the delivery efficiency of the therapeutic molecules due to unsuitable particle diameters passing through the respiratory tracts.…”

Section: Insight Into the Ldh Agglomeration/ Aggregationmentioning

confidence: 99%

“…Typically, the particles with the biggest sizes are mixed in the dry state with the smallest to disperse them, then, after a mechanical stimulus, the smallest particles are more isolated and the biggest ones are removed through a sieving step. [55][56][57][60][61][62] To correctly achieve this dispersion, the bigger particles should stand against mechanical constraints imposed by the fluidizing device as well as being chemically inert. The smallest particles have less probability of interacting with others because of the presence of the bigger particles blocking their dynamic behaviour.…”

Section: Can Powder Rheology Inspire Ldh Dispersion?mentioning

confidence: 99%

Layered double hydroxides: where should research stress on for massive scaling up?

Dazon,

Taviot-Guého,

Prévot

2023

Mater. Adv.

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“…Nebulizers are one of the oldest clinically used aerosol generating systems and form a mist of micronized fine particles of a solid or liquid active pharmaceutical ingredients (API) that can be inhaled into the lungs ( 43 ). Particle size is expressed as mass median aerodynamic diameter (MMAD) and lung surfactant particles should be within a 1 to 5 μm range ( 44 ).…”

Section: Nebulizationmentioning

confidence: 99%

Aerosol Delivery of Lung Surfactant and Nasal CPAP in the Treatment of Neonatal Respiratory Distress Syndrome

Walther

Waring²

2022

Front. Pediatr.

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After shifting away from invasive mechanical ventilation and intratracheal instillation of surfactant toward non-invasive ventilation with nasal CPAP and less invasive surfactant administration in order to prevent bronchopulmonary dysplasia in preterm infants with respiratory distress syndrome, fully non-invasive surfactant nebulization is the next Holy Grail in neonatology. Here we review the characteristics of animal-derived (clinical) and new advanced synthetic lung surfactants and improvements in nebulization technology required to secure optimal lung deposition and effectivity of non-invasive lung surfactant administration. Studies in surfactant-deficient animals and preterm infants have demonstrated the safety and potential of non-invasive surfactant administration, but also provide new directions for the development of synthetic lung surfactant destined for aerosol delivery, implementation of breath-actuated nebulization and optimization of nasal CPAP, nebulizer circuit and nasal interface. Surfactant nebulization may offer a truly non-invasive option for surfactant delivery to preterm infants in the near future.

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State-of-the-art review of the application and development of various methods of aerosol therapy

Cited by 9 publications

References 286 publications

Comparison of the Application of Vibrating Mesh Nebulizer and Jet Nebulizer in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta‐analysis

Comparison of the Application of Vibrating Mesh Nebulizer and Jet Nebulizer in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta‐analysis

Layered double hydroxides: where should research stress on for massive scaling up?

Aerosol Delivery of Lung Surfactant and Nasal CPAP in the Treatment of Neonatal Respiratory Distress Syndrome

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