State-of-the-art reperfusion strategies for acute ischemic stroke

Cohen, José E.; Itshayek, Eyal; Moskovici, Samuel; Gomori, John M.; Fraifeld, Shifra; Eichel, Roni; Leker, Ronen R.

doi:10.1016/j.jocn.2010.10.008

Cited by 34 publications

(32 citation statements)

References 55 publications

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“…Median baseline NIHSS score was 19 (range [16][17][18][19][20][21][22]. The MCA was occluded in 8 patients and the ICA in 5.…”

Section: Figs 8 Andmentioning

confidence: 99%

“…However, this technique has raised safety concerns because antiplatelet medications are required after the procedure to avoid acute stent thrombosis. Other risks include long-term restenosis in patients with a permanently implanted device and permanent side branch and perforator occlusion due to the compressed thrombus [ 16 ]. Self-expanding stents are usually preferred over balloon-mounted stents.…”

Section: Other Mechanical Techniques: Angioplasty and Permanent Stentingmentioning

confidence: 99%

“…In 1999, stroke was responsible for an estimated5.54 million deaths worldwide [ 16 , 54 ]. The last decade has witnessed rapid advances in our understanding of the physiopathology and neuroimaging of cerebral ischemia [ 16 ]. The currently recommended therapy is intravenous tissue plasminogen activator (IV-tPA) to be administered close to the onset of symptoms [ 33 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, randomized trials testing their clinical benefi t against IV thrombolysis, the current gold standard [ 19 ], are lacking, and such trials are becoming increasingly diffi cult to perform because of the rapid evolution of the multimodal approach and the constant introduction of new and improved devices. Furthermore, true clinical success depends not only on timely reperfusion but also on the appropriate degree of reperfusion: recanalization and reperfusion of ischemic tissue may occasionally exacerbate tissue damage by reperfusion injury, cerebral edema, and hemorrhagic transformation [ 16 ]. Therefore, to investigate the therapeutic value of mechanical thrombectomy devices in AIS, we conducted a comprehensive review of recent trials using mechanical endovascular therapy with and without thrombolysis.…”

Section: Introductionmentioning

confidence: 99%

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State-of-the-Art Endovascular Treatment of Acute Ischemic Stroke

Guy

Mazighi

Pereira

et al. 2014

Advances and Technical Standards in Neurosurgery

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Stroke is the third leading cause of death in the USA. An estimated 795,000 new or recurrent stroke events occur annually, mostly ischemic in nature. Arterial recanalization and subsequent reperfusion performed shortly after symptom onset can help to restore brain function in acute ischemic stroke (AIS). The only treatment currently approved by the United States Food and Drug Administration is intravenous tissue plasminogen activator, administered within 4.5 h of symptom onset. However, this short window often precludes effective intervention. Mechanical neurothrombectomy devices offer many potential advantages over pharmacologic thrombolysis, including more rapid achievement of recanalization, enhanced efficacy in treating large-vessel occlusions, and a potentially lower risk of hemorrhagic events. The goal of this chapter is to describe the state-of-the-art neurothrombectomy devices and stenting techniques for endovascular treatment of acute ischemic stroke, as well as to highlight recent advances in reperfusion therapies. Ongoing clinical trials, some with randomized, controlled designs, are included.

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“…Median baseline NIHSS score was 19 (range [16][17][18][19][20][21][22]. The MCA was occluded in 8 patients and the ICA in 5.…”

Section: Figs 8 Andmentioning

confidence: 99%

Section: Other Mechanical Techniques: Angioplasty and Permanent Stentingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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State-of-the-Art Endovascular Treatment of Acute Ischemic Stroke

Guy

Mazighi

Pereira

et al. 2014

Advances and Technical Standards in Neurosurgery

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“…[7][8][9][10][11][12] Our group has performed this procedure in patients with acute BAO in an attempt to improve their neurologic symptoms and clinical outcomes. In the present study, we evaluated feasibility, safety, and efficacy of emergency stent placement following intra-arterial thrombolysis for patients suffering from acute BAO.…”

Section: Introductionmentioning

confidence: 99%

Emergent stent placement following intra-arterial thrombolysis for the treatment of acute basilar artery occlusion

Shi

Wang

Zhu

et al. 2012

Journal of Clinical Neuroscience

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Predictors of prognosis and treatment outcome in central retinal artery occlusion: local intra-arterial fibrinolysis vs. conservative treatment

Pielen

Pantenburg²,

Schmoor

et al. 2015

Neuroradiology

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CHD, time from occlusion to treatment and smoking influence BCVA at baseline and at month 1 (prognostic effect). Patients treated within 12 h are more likely to profit from treatment. In multivariate analysis, there is no clear trend to benefit from LIF even in patients with young age, no CHD and early treatment. Based on this preliminary report on a rather small sample size, we do not recommend LIF in CRAO patients.

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State-of-the-art reperfusion strategies for acute ischemic stroke

Cited by 34 publications

References 55 publications

State-of-the-Art Endovascular Treatment of Acute Ischemic Stroke

State-of-the-Art Endovascular Treatment of Acute Ischemic Stroke

Emergent stent placement following intra-arterial thrombolysis for the treatment of acute basilar artery occlusion

Predictors of prognosis and treatment outcome in central retinal artery occlusion: local intra-arterial fibrinolysis vs. conservative treatment

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