State of the art on targeted memory reactivation: Sleep your way to enhanced cognition

Schouten, Daphne I.; Pereira, Sofia Isabel Ribeiro; Tops, Mattie; Louzada, Fernando Mazzilli

doi:10.1016/j.smrv.2016.04.002

Cited by 90 publications

(68 citation statements)

References 67 publications

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“…However, the potential benefit depends on the paradigm used, the type of the cues used, and the timing of the stimulation. Moreover, at the translational level, the application of TMR to address real‐world issues, for example, to increase learning abilities in students, to compensate for the cognitive deficits observed in sleep or neurodegenerative disorders, to facilitate rehabilitation programs, or to aid clinicians in treating psychiatric disorders, has yet to be achieved. To sum up, the studies presented in the current review show promising but not systematic results for TMR, and further studies are needed to optimize this technique and facilitate its translation to real‐word applications.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, several different cues can be used in the same experiment, and also allows for cues to be semantically related to individual items. However, whether there is an advantage of using cues conceptually associated with the learned material is still debated and requires further exploration. Additionally, auditory stimuli can be used with less invasive instrumentation (e.g., earphones or speaker) compared to odors, which require the use of olfactometers and nasal masks (or similar delivery systems).…”

Section: Differences Between Sensory Cuesmentioning

confidence: 99%

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Shaping memory consolidation via targeted memory reactivation during sleep

Cellini

Capuozzo

2018

Annals of the New York Academy of Sciences

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Recent studies have shown that the reactivation of specific memories during sleep can be modulated using external stimulation. Specifically, it has been reported that matching a sensory stimulus (e.g., odor or sound cue) with target information (e.g., pairs of words, pictures, and motor sequences) during wakefulness, and then presenting the cue alone during sleep, facilitates memory of the target information. Thus, presenting learned cues while asleep may reactivate related declarative, procedural, and emotional material, and facilitate the neurophysiological processes underpinning memory consolidation in humans. This paradigm, which has been named targeted memory reactivation, has been successfully used to improve visuospatial and verbal memories, strengthen motor skills, modify implicit social biases, and enhance fear extinction. However, these studies also show that results depend on the type of memory investigated, the task employed, the sensory cue used, and the specific sleep stage of stimulation. Here, we present a review of how memory consolidation may be shaped using noninvasive sensory stimulation during sleep.

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Section: Resultsmentioning

confidence: 99%

Section: Differences Between Sensory Cuesmentioning

confidence: 99%

Shaping memory consolidation via targeted memory reactivation during sleep

Cellini

Capuozzo

2018

Annals of the New York Academy of Sciences

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“…Odors are strong at eliciting contextual retrieval cues for declarative and emotional memory (Schouten et al, 2017). Besides that odors rarely awaken sleepers, making them thus very useful for TMR paradigms (Rasch, Büchel, Gais, & Born, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Besides that odors rarely awaken sleepers, making them thus very useful for TMR paradigms (Rasch, Büchel, Gais, & Born, 2007). Auditory stimuli on the other hand are more arousing than odors Schouten et al, 2017) However, they have been more successful than olfactory cues in various domains, including procedural memories. Schouten et al (2017) hypothesize that olfactory stimuli are best suited for declarative and emotional memories, while auditory can be best used for procedural memories.…”

Section: Introductionmentioning

confidence: 99%

“…Auditory stimuli on the other hand are more arousing than odors Schouten et al, 2017) However, they have been more successful than olfactory cues in various domains, including procedural memories. Schouten et al (2017) hypothesize that olfactory stimuli are best suited for declarative and emotional memories, while auditory can be best used for procedural memories. Auditory cues have the advantage of the ability to be congruent with the learning material (for example, in a TMR paradigm that uses a word learning task, the words can be re-exposed in sleep by verbally presenting the participants with the cued words).…”

Section: Introductionmentioning

confidence: 99%

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Targeted Memory Reactivation Increases Memory Recall: A Meta-analysis

Lieber¹

2019

Preprint

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Research on Targeted Memory Reactivation (TMR) shows that it's a successful for increasing memory recall. However, As of yet no systematic study had been conducted to evaluate to what extend TMR can increase recall. This study used a comprehensive literature search to attempt to find all studies conducted in which TMR is used to increase memory recall. Methodological quality, study characteristics and where possible descriptive statistics were extracted from the studies. In total, 41 studies were identified, 26 of which included enough descriptive data to be included in the meta-analysis. The results indicated that the average methodological quality was good. Furthermore, TMR significantly increased memory recall. The subgroup analysis for modality was not significant, while the subgroup analysis for type of memory did yield a significant result. Overall, TMR seems to have small to medium effect on memory recall, is independent of modality and depends on memory. reactivation of hippocampal maps predict spatial memory performance. Nature neuroscience, 13(8), 995.

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Concise Review: Regulatory Influence of Sleep and Epigenetics on Adult Hippocampal Neurogenesis and Cognitive and Emotional Function

et al. 2018

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Neural stem and progenitor cells continue to generate new neurons in particular regions of the brain during adulthood. One of these neurogenic regions is the dentate gyrus (DG) of the hippocampus, which plays an important role in cognition and emotion. By exploiting this innate neuronal regeneration mechanism in the DG, new technologies have the potential to promote resistance to or recovery from brain dysfunction or degeneration. However, a deeper understanding of how adult DG neurogenesis is regulated by factors such as sleep and epigenetic modifications of gene expression could lead to further breakthroughs in the clinical application of neural stem and progenitor cells. In this review, we discuss the functions of adult-born DG neurons, describe the epigenetic regulation of adult DG neurogenesis, identify overlaps in how sleep and epigenetic modifications impact adult DG neurogenesis and memory consolidation, and suggest ways of using sleep or epigenetic interventions as therapies for neurodegenerative and psychiatric disorders. By knitting together separate strands of the literature, we hope to trigger new insights into how the functions of adult-generated neurons are directed by interactions between sleep-related neural processes and epigenetic mechanisms to facilitate novel approaches to preventing and treating brain disorders such as depression, post-traumatic stress disorder, and Alzheimer's disease. STEM CELLS 2018; 00:000-000 SIGNIFICANCE STATEMENTNew technologies utilizing neural stem cells in the adult hippocampus could potentially be used to promote innate resistance to or recovery from brain dysfunction or degeneration. Accumulating evidence indicates that adult hippocampal neurogenesis contributes to cognitive and emotional processing and is regulated by sleep and epigenetic modification of gene expression. Therefore, a richer understanding of how the interplay between sleep and epigenetics impacts adult hippocampal neurogenesis and thereby influences hippocampal function can help advance efforts to employ behavioral sleep interventions, epigenetic drugs, and novel neural stem cell-based therapeutic strategies for preventing or treating neurodegenerative and psychiatric disorders.

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State of the art on targeted memory reactivation: Sleep your way to enhanced cognition

Cited by 90 publications

References 67 publications

Shaping memory consolidation via targeted memory reactivation during sleep

Shaping memory consolidation via targeted memory reactivation during sleep

Targeted Memory Reactivation Increases Memory Recall: A Meta-analysis

Concise Review: Regulatory Influence of Sleep and Epigenetics on Adult Hippocampal Neurogenesis and Cognitive and Emotional Function

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