2023
DOI: 10.3390/biomedicines11041045
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State of the Art of Cardiac Amyloidosis

Abstract: Cardiac amyloidosis is defined by extracellular deposition of misfolded proteins in the heart. The most frequent cases of cardiac amyloidosis are caused by transthyretin and light chain amyloidosis. This condition is underdiagnosed, and its incidence has been continuously rising in recent studies because of the aging of the population and the development of noninvasive multimodal diagnostic tools. Amyloid infiltration affects all cardiac tunics and causes heart failure with preserved ejection fraction, aortic … Show more

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“…Heart failure with preserved EF (HFpEF), aortic stenosis, conduction disorders, arrhythmias, and thrombotic phenomena are the major cardiac manifestations. 7 Table 1 shows the major cardiac and extracardiac manifestations of amyloidosis. Clinically heart failure, especially in the elderly that is poorly responding to conventional therapies, associated musculoskeletal/ neurological manifestations, proteinuria, nephrotic syndrome, and autonomic disturbances are highly suggestive to work up for CA.…”
mentioning
confidence: 99%
“…Heart failure with preserved EF (HFpEF), aortic stenosis, conduction disorders, arrhythmias, and thrombotic phenomena are the major cardiac manifestations. 7 Table 1 shows the major cardiac and extracardiac manifestations of amyloidosis. Clinically heart failure, especially in the elderly that is poorly responding to conventional therapies, associated musculoskeletal/ neurological manifestations, proteinuria, nephrotic syndrome, and autonomic disturbances are highly suggestive to work up for CA.…”
mentioning
confidence: 99%