State of the Art of Small‐Diameter Vessel‐Polyurethane Substitutes

Li, Jinge; Chen, Zhaobin; Yang, Xiaoniu

doi:10.1002/mabi.201800482

Cited by 17 publications

(14 citation statements)

References 120 publications

(129 reference statements)

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“…It is found that for PCU1 with 63–75 µm of micropore size and best endothelialization, 4.65 ± 0.28% of compliance is similar to that of saphenous vein (4.4%), 23.83 ± 3.48 MPa of tensile strength, and 210.5 ± 14.2 kPa (equivalent of ca. 1580 mm Hg) of burst pressure are also within the safe range . The micropore structure does not impact on the cytotoxicity of the ASDBVs, approximate or over 80% of NIH 3T3 cells are recovered for all the samples under different conditions (Table and ), which is at the same level of the smooth sample PCU0.…”

Section: Resultsmentioning

confidence: 65%

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Small diameter blood vessels with controllable micropore structure induced by centrifugal force for improved endothelialization

Gao

Chen

et al. 2020

Engineering in Life Sciences

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The micropore structure is prerequisite for fast and durable endothelialization of artificial small diameter blood vessels (ASDBVs). Although some methods, such as salt leaching, coagulation, and electrospinning, have been developed to construct micropores for ASDBVs, the uncontrollability of the structure and the complicated procedures of the process are still the issues to be concerned about. In this study, a compact device based on the principle of centrifugal force is established and used to prepare polyurethane (PU) ASDBVs with micropore structures by blasting different porogens. It is found that the glass beads could construct micropores with regular round shape, uniform distribution, and controllable size (60-350 µm), which significantly improves the endothelialization of PU-based ASDBVs, especially when the pore size is about 60 µm. This method is easy-accessible and wide-applicable, which provides a new pathway for the research and development of ASDBVs. K E Y W O R D Scentrifugal force, endothelialization, micropore structure, polyurethane, small diameter blood vessel

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Section: Resultsmentioning

confidence: 65%

“…In this study, PCU is selected as the matrix to prepare microporous ASDBVs due to its easy processing, excellent mechanical strength, and good biostability and biocompatibility . Figure 1B, C, and D and E are the SEM pictures of the inner surfaces of ASDBVs prepared by NaCl particles, paraffin spheres, and glass beads, respectively.…”

Section: Resultsmentioning

confidence: 99%

Small diameter blood vessels with controllable micropore structure induced by centrifugal force for improved endothelialization

Gao

Chen

et al. 2020

Engineering in Life Sciences

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“…Under ideal conditions, the degradation rate must be such that scaffold integrity is maintained during graft surgery, while allowing new tissue formation 43 . The growth rate of new vascular tissue is still unknown, and it depends on several physical, chemical, and biological factors associated with the physiology and tissue interactions with the scaffold 4 . We observed an increase in weight loss over time, which was directly related to the addition of ECM proteins into the PU.…”

Section: Discussionmentioning

confidence: 99%

“…Biodegradable synthetic polymers, including polylactic acids, polyglycolic acids, polycaprolactones, and polyurethanes, are used as vascular grafts in practice 3 . Among these, polyurethanes (PUs) are particularly flexible, hemocompatible, and mechanically stable polymers that are widely used in vascular applications 4 .…”

Section: Introductionmentioning

confidence: 99%

Extracellular matrix-derived and low-cost proteins to improve polyurethane-based scaffolds for vascular grafts

Rodrigues

Lopes

Pereira

et al. 2022

Sci Rep

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Vascular graft surgeries are often conducted in trauma cases, which has increased the demand for scaffolds with good biocompatibility profiles. Biodegradable scaffolds resembling the extracellular matrix (ECM) of blood vessels are promising vascular graft materials. In the present study, polyurethane (PU) was blended with ECM proteins collagen and elastin (Col-El) and gelatin (Gel) to produce fibrous scaffolds by using the rotary jet spinning (RJS) technique, and their effects on in vitro properties were evaluated. Morphological and structural characterization of the scaffolds was performed using scanning electron microscopy (SEM) and atomic force microscopy (AFM). Micrometric fibers with nanometric rugosity were obtained. Col-El and Gel reduced the mechanical strength and increased the hydrophilicity and degradation rates of PU. No platelet adhesion or activation was observed. The addition of proteins to the PU blend increased the viability, adhesion, and proliferation of human umbilical vein endothelial cells (HUVECs). Therefore, PU-Col-El and PU-Gel scaffolds are promising biomaterials for vascular graft applications.

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“…Polyurethane is also widely used in the medical fields for artificial hearts or vessel catheters due to its high biocompatibility and reliability. [ 8 ] The high density alignment of urethane molecules forms a smoother surface and has natural feeling. Polyurethane contains no rubber latex which may cause allergic reactions.…”

Section: Discussionmentioning

confidence: 99%

Superior effectiveness of a newly developed nonadherent polyurethane-coated surgical patty for hemostasis

et al. 2021

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Background: Cotton patty is usually used to aspirate blood and cerebrospinal fluid to maintain a dry field. However, the cotton patty easily adheres to the vessels by capillary action, especially in combination with hemostat. Therefore, re-bleeding may be induced by removal of the cotton patty stuck to the vessel despite initial control of the bleeding. Methods: We have developed a new cotton patty (Non-Stina X ® , Hakujuji, Co., Ltd., Tokyo, Japan) which does not adhere to the vessels. The newly developed cotton patty is made of 100% cotton, with only the contact surface coated with polyurethane film which prevents capillary action. The coated side includes many holes to allow aspiration from both sides. Results: The characteristics of four different surgical patties including our new patty which are available for surgical use in Japan were investigated. Transverse sections of four different surgical patties were investigated by light microscopy (magnification ×150). Our new cotton patty did not show any fluffing on the polyurethane-coated surface. However, other surgical patties showed some fluffing on their surfaces. The friction coefficients of four different surgical patties were investigated. Our new cotton patty had the lowest of the four neurosurgical patties. We confirmed the nonadherent characteristic using with hemostats of gelatinous sponge or fibrin glue-soaked oxidized cellulose cotton during hemostasis in neurosurgical procedures. The polyurethane-coated cotton patty could be removed easily from the hemostats without re-bleeding. Conclusions: The newly developed polyurethane-coated cotton patty is more effective for bleeding control from vessels with several types of hemostat due to the nonadherent characteristics.

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State of the Art of Small‐Diameter Vessel‐Polyurethane Substitutes

Cited by 17 publications

References 120 publications

Small diameter blood vessels with controllable micropore structure induced by centrifugal force for improved endothelialization

Small diameter blood vessels with controllable micropore structure induced by centrifugal force for improved endothelialization

Extracellular matrix-derived and low-cost proteins to improve polyurethane-based scaffolds for vascular grafts

Superior effectiveness of a newly developed nonadherent polyurethane-coated surgical patty for hemostasis

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