State‐of‐the‐Art Nrf2 Inhibitors: Therapeutic Opportunities in Non‐Cancer Diseases
Emil G. Ayala‐Cosme,
Deborah Yang,
Kyara Vences
et al.
Abstract:Nrf2 is a cytoprotective transcription factor that induces the transcription of genes responsible for the cell’s response to oxidative stress. While Nrf2 activation has led to the development of clinically relevant therapeutics, the oncogenic role of Nrf2 in the proliferation of cancer cells has underscored the complex nature of Nrf2 and the necessity for the development of Nrf2 inhibitors. Although the application of Nrf2 inhibitors appears limited as anticancer agents, recent studies have begun to pinpoint t… Show more
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