State-of-the-art mass spectrometry for point-of-care and other applications: A hands-on intensive short course for undergraduate students

Fedick, Patrick W.; Bain, Ryan M.; Miao, Shunshun; Pirro, Valentina; Cooks, R. Graham

doi:10.1016/j.ijms.2017.04.008

Cited by 12 publications

(9 citation statements)

References 47 publications

(25 reference statements)

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“…State-of-the-art mass spectrometry for point-of-care and other applications: A hands-on intensive short course for undergraduate students, pp. 22–28 (ref ). Copyright 2017, with permission from Elsevier.…”

Section: Future Directionsmentioning

confidence: 99%

“…To address this issue, Purdue University’s Center for Analytical Instrumentation Development (CAID) () (Figure g), developed in 2008 by Prof. Cooks and many pioneers of AIMS, has been holding annual workshops for undergraduate students and industrial students to obtain hands-on experience in state-of-the-art instruments in the MS field such as innovative ambient ionization techniques . Receiving positive feedback from the attendants, the CAID workshop is undoubtedly a successful model through which nonexperts are immersed in mass spectrometry and serves as a reliable framework that can be adopted by educators across the world.…”

Section: Future Directionsmentioning

confidence: 99%

“…purdue.edu/discoverypark/caid) (Figure 7g), developed in 2008 by Prof. Cooks and many pioneers of AIMS, has been holding annual workshops for undergraduate students and industrial students to obtain hands-on experience in state-ofthe-art instruments in the MS field such as innovative ambient ionization techniques. 84 Receiving positive feedback from the attendants, the CAID workshop is undoubtedly a successful model through which nonexperts are immersed in mass spectrometry and serves as a reliable framework that can be adopted by educators across the world. On the other hand, such outreach activities require academic contributions by research institutions and specialists and, more importantly, support from an MS industry that is willing to donate instruments for educational purposes.…”

Section: ■ Future Directionsmentioning

confidence: 99%

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Ambient Ionization Mass Spectrometry Today and Tomorrow: Embracing Challenges and Opportunities

et al. 2019

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Ambient ionization mass spectrometry (AIMS) has grown into a group of emerging analytical techniques that allow rapid, real-time, high-throughput, in situ, and in vivo analysis in many scientific fields including biomedicine, pharmaceuticals, and forensic sciences. While dozens of AIMS techniques have been introduced over the past two decades, their broad commercial and industrial use is still restricted by multiple challenges. In this Perspective, we discuss the most relevant technical challenges facing AIMS, i.e., reproducibility, quantitative ability, molecular coverage, sensitivity, and data complexity, and scientists' recent attempts to overcome these hurdles. Furthermore, we present future directions of AIMS from our perspective, including the necessity that efforts should be made to unravel blind biomolecules in routine analysis, the construction of a data depository for AIMS users, the full automation of pipelines for prospect integration in a robotic laboratory, the movement toward on-site tests, and the expansion of outreach to motivate government officials in policymaking. We anticipate that, with progress in these critical but immature areas, AIMS technology will keep evolving to become a more robust and user-friendly set of technologies and, consequently, be translated into everyday life practice.

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Section: Future Directionsmentioning

confidence: 99%

Section: Future Directionsmentioning

confidence: 99%

Section: ■ Future Directionsmentioning

confidence: 99%

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Ambient Ionization Mass Spectrometry Today and Tomorrow: Embracing Challenges and Opportunities

et al. 2019

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“…The pedagogical aims of this laboratory exercise are twofold: (i) to introduce students to synthetic methodologies not typically seen in the second-year organic chemistry laboratory and (ii) to introduce students to mass spectrometry as an analytical and a synthetic tool. 27 In this laboratory exercise, students were able to synthesize material in nontraditional ways and then analyze the products by nanoelectrospray mass spectrometry or paper spray mass spectrometry. The reaction studied here is the first step in a two-step amine displacement reaction that is mediated by the pyrylium species.…”

Section: ■ Introductionmentioning

confidence: 99%

Accelerated Chemical Synthesis: Three Ways of Performing the Katritzky Transamination Reaction

et al. 2019

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Typical laboratory exercises for undergraduate organic chemistry students involve bulk phase reactions with work up of product. In this study, students performed accelerated versions of the Katritzky reaction of para-substituted anilines with pyrylium salts in three ways: (i) by dropcasting reagents onto a paper surface and allowing solvent to evaporate, (ii) by evaporation of solvent from the reagent mixture in a rotary evaporator, and (iii) at an organic/water interface (“on water”). Students determined the reaction yield for all three accelerated reactions as well as in the conventional bulk phase by mass spectrometry. Acceleration factors (the ratio of the product to reagent ion signals in the accelerated vs conventional reaction) were used to compare the paper spray and rotary evaporator method as well as the “on water” method. Substituent effects were explored by using substituted anilines. Students’ understanding of acceleration of organic reactions was increased as seen in both laboratory reports and exit interviews.

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“…If a brief introduction to the operation principles is warranted, they can be explained using basic physics with which most students should be familiar (e.g., kinetic energy) or which will be introduced as part of the chemistry curriculum. Incorporation of mass spectrometry-based laboratory activities into the upper-division undergraduate laboratory environment is now well-established and widespread. − Albeit less widespread, there has also been a move to incorporate mass spectrometry in introductory-level laboratory work. , There have been several laboratory units developed incorporating mass spectrometry as a method for investigating isotopic abundances and patterns of various elements or molecules; while not all of these were aimed specifically at introductory courses, they are, perhaps, closest to mass spectrometry as a complement to the material typically taught in a general chemistry course. − Various overviews of mass spectrometry and its applications have previously been presented within the education community, including early overviews of mass spectrometry, − a history of mass spectrometry with a focus on its role in the Manhattan Project, a feature on the 2002 Nobel Prize in Chemistry summarizing the use of mass spectrometry for protein analysis, and a history of the application of mass spectrometry to the analysis of polymers . Mass spectrometry is already typically introduced to introductory/general chemistry students to varying degrees depending on the instructor and the textbook.…”

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confidence: 99%

Instructor’s Reference for Integrating Mass Spectrometry into the General Chemistry Classroom

Patrick

2020

J. Chem. Educ.

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Mass spectrometry is one of the few instrumental analysis techniques that can be relatively well-understood with physics/chemistry knowledge typical of an advanced high school or a beginning undergraduate student. This positions mass spectrometry well to be used as a bridge between abstract concepts typically set as learning goals in courses at those levels, practical problem sets based on realistic data graphs, and historical or applications case studies. Such case studies tie general chemistry learning goals in with areas of student interest, potential student career paths, and/or areas with which students might already be more familiar. The purpose of this work is to provide (1) an introduction to mass spectrometry, (2) a discussion of mass spectrometry applications which are both relevant to the general chemistry curriculum and likely of interest to the student population, and (3) examples of potential mass spectrometry-based exercises that could be integrated into classroom exercises or student assessment. Importantly, all three of these purposes are addressed at a level easily accessible for either instructors with little to no mass spectrometry background or for students in the target audience. An additional goal of the proposed activities is to encourage development of student skills in graph reading and analysis. Thus, this work’s aim is to serve as an instructor’s reference, bridging the gap between the field of mass spectrometry and the introductory or general chemistry classroom.

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State-of-the-art mass spectrometry for point-of-care and other applications: A hands-on intensive short course for undergraduate students

Cited by 12 publications

References 47 publications

Ambient Ionization Mass Spectrometry Today and Tomorrow: Embracing Challenges and Opportunities

Ambient Ionization Mass Spectrometry Today and Tomorrow: Embracing Challenges and Opportunities

Accelerated Chemical Synthesis: Three Ways of Performing the Katritzky Transamination Reaction

Instructor’s Reference for Integrating Mass Spectrometry into the General Chemistry Classroom

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