State-of-the-art colloidal particles and unique interfaces-based SARS-CoV-2 detection methods and COVID-19 diagnosis

Saatçi, Ebru; Natarajan, Satheesh

doi:10.1016/j.cocis.2021.101469

Cited by 15 publications

(11 citation statements)

References 91 publications

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“…They also reported that the major hematological indicators in COVID-19 include the absolute and relative (ratios) counts of the circulating neutrophils and lymphocytes in the blood [ 9 ]. Several studies also reported clinical incidences of lymphopenia in progressing and more severe cases of COVID-19 infections in patient populations [ 10 ]. Of the numerous biomarkers in the progression of COVID-19 infection, the most conspicuous ones include creatine kinase, D-dimer, and troponin.…”

Section: Diagnosis Of Sars-cov-2mentioning

confidence: 99%

Carbon nanotubes in COVID-19: A critical review and prospects

Varghese

Salvi

Sood

et al. 2022

Colloid and Interface Science Communications

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Section: Diagnosis Of Sars-cov-2mentioning

confidence: 99%

Carbon nanotubes in COVID-19: A critical review and prospects

Varghese

Salvi

Sood

et al. 2022

Colloid and Interface Science Communications

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“…SPEs were customized in various configurations for SARS-CoV-2 detection (some components of the virus itself) [ 248 , 265 , 266 , 267 , 268 , 269 ], but also for the detection of some biomarkers useful for Covid 19 diagnosis (C-reactive protein, interleukins, tumor necrosis factor alpha, interferons, glutamate, breath pH, lymphocytes, platelets, neutrophils and D-dimer) [ 270 ]. Nanomaterials such as AuNPs, calixarene functionalized graphene, Au@Fe 3 O 4 nanocomposite (400 nm) and carbon black served as catalysts, bioreceptor or labels, but, also, they improved the electrochemical performance of the SPE-based sensors applied for the virus detection [ 248 , 265 , 266 , 267 , 268 , 269 ]. In the case of biomarkers sensing, several nanomaterials have been employed for SPEs modification, such as rGO, AuNPs and Ag/Pt-graphene nanocomposite [ 270 ].…”

Section: Metal Nanoparticles and Carbon-based Nanomaterials In (Bio)sensors Designmentioning

confidence: 99%

Metal Nanoparticles and Carbon-Based Nanomaterials for Improved Performances of Electrochemical (Bio)Sensors with Biomedical Applications

et al. 2021

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Monitoring human health for early detection of disease conditions or health disorders is of major clinical importance for maintaining a healthy life. Sensors are small devices employed for qualitative and quantitative determination of various analytes by monitoring their properties using a certain transduction method. A “real-time” biosensor includes a biological recognition receptor (such as an antibody, enzyme, nucleic acid or whole cell) and a transducer to convert the biological binding event to a detectable signal, which is read out indicating both the presence and concentration of the analyte molecule. A wide range of specific analytes with biomedical significance at ultralow concentration can be sensitively detected. In nano(bio)sensors, nanoparticles (NPs) are incorporated into the (bio)sensor design by attachment to the suitably modified platforms. For this purpose, metal nanoparticles have many advantageous properties making them useful in the transducer component of the (bio)sensors. Gold, silver and platinum NPs have been the most popular ones, each form of these metallic NPs exhibiting special surface and interface features, which significantly improve the biocompatibility and transduction of the (bio)sensor compared to the same process in the absence of these NPs. This comprehensive review is focused on the main types of NPs used for electrochemical (bio)sensors design, especially screen-printed electrodes, with their specific medical application due to their improved analytical performances and miniaturized form. Other advantages such as supporting real-time decision and rapid manipulation are pointed out. A special attention is paid to carbon-based nanomaterials (especially carbon nanotubes and graphene), used by themselves or decorated with metal nanoparticles, with excellent features such as high surface area, excellent conductivity, effective catalytic properties and biocompatibility, which confer to these hybrid nanocomposites a wide biomedical applicability.

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“…Shetti et al described conventional and nanotechnology-based sensors for COVID-19 [ 77 ]. Recent efforts in the applications of colloidal particles and nanoparticles for the diagnostics and treatment of COVID-19 have also been summarized [ 78 , 79 ]. Kotru et al reviewed electrochemical sensing technologies prognostics purposes [ 80 ].…”

Section: Perspectives and Conclusionmentioning

confidence: 99%

Pushing the detection limits: strategies towards highly sensitive optical-based protein detection

Momenbeitollahi

Cloet

2021

Anal Bioanal Chem

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Proteins are one of the main constituents of living cells. Studying the quantities of proteins under physiological and pathological conditions can give valuable insights into health status, since proteins are the functional molecules of life. To be able to detect and quantify low-abundance proteins in biofluids for applications such as early disease diagnostics, sensitive analytical techniques are desired. An example of this application is using proteins as biomarkers for detecting cancer or neurological diseases, which can provide early, lifesaving diagnoses. However, conventional methods for protein detection such as ELISA, mass spectrometry, and western blotting cannot offer enough sensitivity for certain applications. Recent advances in optical-based micro- and nano-biosensors have demonstrated promising results to detect proteins at low quantities down to the single-molecule level, shining lights on their capacities for ultrasensitive disease diagnosis and rare protein detection. However, to date, there is a lack of review articles synthesizing and comparing various optical micro- and nano-sensing methods of enhancing the limits of detections of the antibody-based protein assays. The purpose of this article is to critically review different strategies of improving assay sensitivity using miniaturized biosensors, such as assay miniaturization, improving antibody binding capacity, sample purification, and signal amplification. The pros and cons of different methods are compared, and the future perspectives of this research field are discussed.

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State-of-the-art colloidal particles and unique interfaces-based SARS-CoV-2 detection methods and COVID-19 diagnosis

Cited by 15 publications

References 91 publications

Carbon nanotubes in COVID-19: A critical review and prospects

Carbon nanotubes in COVID-19: A critical review and prospects

Metal Nanoparticles and Carbon-Based Nanomaterials for Improved Performances of Electrochemical (Bio)Sensors with Biomedical Applications

Pushing the detection limits: strategies towards highly sensitive optical-based protein detection

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