In this chapter, we use the Takagi-Sugeno (T-S) fuzzy model to model the nuclear reactor power control system (NRPCS), which is nonlinear time-varying and not easy to control. First, we give the point-kinetic nonlinear time-varying model of the NRPCS; then we choose the reactor power as the premise variable, propose the membership, and present a T-S fuzzy model for the NRPCS. Finally, an H∞ controller is investigated. The numerical example illustrates the advantage of the proposed model.