State-dependent retention produced with estrus in rats

Costanzo, Dominic J.; Riccio, David C.; Kissinger, Steven C.

doi:10.1016/0031-9384(94)00007-r

Cited by 8 publications

(7 citation statements)

References 8 publications

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“…This latter hypothesis is further supported by the finding that the 5 women whose data were omitted from the present study because of irregularities in their endocrine profiles, also showed a high positive correlation between labium minus temperature increase during the first and second visit to the laboratory (without vibration r = .96, p = .009; with vibration r = .67, p = ns). The tenor of this hypothesis is reminiscent of findings obtained with rats, in which state-dependent memory retention (a conditioned flavor aversion) was found after a learning experience with or without estrogen (Constanzo et al, 1995). These authors state 'whether tested while estrus or anestrus, the aversion was strongest if the test state matched the training state' (Constanzo et al, 1995(Constanzo et al, , p. 1010.…”

Section: Discussionmentioning

confidence: 95%

“…The tenor of this hypothesis is reminiscent of findings obtained with rats, in which state-dependent memory retention (a conditioned flavor aversion) was found after a learning experience with or without estrogen (Constanzo et al, 1995). These authors state 'whether tested while estrus or anestrus, the aversion was strongest if the test state matched the training state' (Constanzo et al, 1995(Constanzo et al, , p. 1010.…”

Section: Discussionmentioning

confidence: 95%

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Sexual arousability and the menstrual cycle

Slob

Bax

Hop

et al. 1996

Psychoneuroendocrinology

100

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We have repeated a study of the objective (labium minus temperature) and subjective (semantic scales) changes in sexual arousability over the menstrual cycle to erotic video stimulation in 20 women with natural cycles. We extended the study with concomitant vibrotactile stimulation of the clitoral region. In an earlier study women tested for the first time in their follicular phase were sexually more aroused (as indicated by greater increase in labium minus temperature) than women tested for the first time during their luteal phase. When these women were retested in their alternative phase of the menstrual cycle, those who were then follicular did not score higher than those who were then luteal. We then postulated the involvement of a cognitive or conditioned phenomenon which was responsible for the women's repeating their initial phase-dependent response when tested the second time in their alternative phase of the cycle. Identical results were obtained in the present study as far as sexual arousability is concerned during the first test, i.e. follicular women generally scored higher than luteal women; this difference in response persisted during the second test. Concomitant vibrotactile stimulation had no effect on labium minus temperature change but raised subjective sexual arousal and caused a 'more pleasurable' response to the erotic video. Subjective sexual and subjective genital arousal were positively correlated, but neither was significantly correlated with labium minus temperature change. The relationship between menstrual cycle phase and sexual arousal was further substantiated by the reported greater increase in sexual desire after the first erotic video in follicular women than in luteal women. This increased desire, as well as more erotic fantasies, persisted during the next 24 h. In conclusion, studies into effects of menstrual cycle phase on sexual arousability in the laboratory should seriously consider the possible learning and conditioning effects as suggested by the present investigation.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 95%

Sexual arousability and the menstrual cycle

Slob

Bax

Hop

et al. 1996

Psychoneuroendocrinology

100

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“…Currently, it is not entirely clear why females that are not exposed to ovarian hormones through puberty would respond to inhibition of aromatase activity with a pattern that is reminiscent of adult female rats not given an inhibitor. However, as described above, data indicate that sex differences in sweet preferences as well as in a number of kinds of learning appear to emerge around the time of puberty in rats (e.g., Costanzo et al, 1995; Hodes and Shors, 2005; Wade and Zucker, 1969), suggesting that puberty represents a period during which behavioral and, presumably, structural changes relevant to feeding and learning occur. Further, sex differences in organization of central nervous system structures have been documented to appear following the adolescent/pubertal period in rodents (e.g., Gonzales et al, 2012; Konkle and McCarthy, 2011; Koshibu et al, 2005; Nugent et al, 2011; Schwarz et al, 2010; Wilson et al, 2011).…”

Section: Discussionmentioning

confidence: 80%

“…Taste aversions also appear to be affected by estrogens with administration of estradiol to OVX rats accelerating extinction of learned aversions (Chambers, 1976, 1985; Yuan and Chambers, 1999). Further, sex differences in these classical conditioning tasks appear to emerge only after the onset of puberty (Costanzo et al, 1995; Hodes and Shors, 2005). …”

Section: Discussionmentioning

confidence: 99%

Influence of ovarian and non-ovarian estrogens on weight gain in response to disruption of sweet taste — calorie relations in female rats

Swithers

Sample²,

Katz³

2013

Hormones and Behavior

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Regulation of energy balance in female rats is known to differ along a number of dimensions compared to male rats. Previous work from our lab has demonstrated that in female rats fed dietary supplements containing high-intensity sweeteners that may disrupt a predictive relation between sweet tastes and calories, excess weight gain is demonstrated only when females are also fed a diet high in fat and sugar, and is evidenced primarily in animals already prone to gain excess weight. In contrast, male rats show excess weight gain when fed saccharin-sweetened yogurt supplements when fed both standard chow diets and diets high in fat and sugar, and regardless of their proneness to excess weight gain. The goal of the present experiments was to determine whether ovarian, or other sources of estrogens, contributes to the resistance to excess weight gain in female rats fed standard chow diets along with dietary supplements sweetened with yogurt. Results of the first experiment indicated that when the ovaries were removed surgically in adult female rats, patterns of weight gain were similar in animals fed saccharin-sweetened compared to glucose-sweetened yogurt supplements. In the second experiment, when the ovaries were surgically removed in adult female rats, and local production of estrogens was suppressed with the aromatase inhibitor anastrozole, females fed the saccharin-sweetened yogurt consumed more energy and gained more weight than females fed the glucose-sweetened yogurt. However, when the ovaries were surgically removed prior to the onset of puberty (at 24 – 25 days of age), females given saccharin-sweetened yogurt along with vehicle gained excess weight. In contrast, weight gain was similar in those given saccharin-sweetened and glucose-sweetened yogurt along with anastrozole. The results suggest that behavioral differences between males and females in response to disruption of sweet→calorie relations may result from differences in patterns of local estrogen production. These differences may be established developmentally during the pubertal period in females.

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“…This effect was only found in subjects trained during the third, but not the second postnatal week, and it is coherent with previous reports (Arias et al, 2012), suggesting that by this age this ethanol effect is either context-independent or it is mediated by cues other than the open field, such as handling or those related to the injection that were present at training and testing. This would not be surprising since drug effects can be effectively conditioned to injection cues (de Brugada et al, 2003, Davis et al, 2010 and various (proximal vs distant) contextual cues can exert differential levels of control over tolerance, at least in adult animals (Costanzo et al, 1995).…”

Section: Please Insert Figure 2b Herementioning

confidence: 99%