State-dependent olfactory processing in freely behaving mice

Schreck, Mary; Zhuang, Liujing; Janke, Emma; Moberly, Andrew H.; Bhattarai, Janardhan P.; Gottfried, Jay A.; Wesson, Daniel W.; Ma, Minghong

doi:10.1016/j.celrep.2022.110450

Cited by 11 publications

(13 citation statements)

References 95 publications

(135 reference statements)

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“…Changes in behavioral state also impact the efficacy of synaptic transmission 55,56 and sensory responses in the cortex 22,51,[57][58][59][60] . Previously it was noted that claustrum activation is less effective during active wake 7,41,45 , but this has not been systematically measured.…”

Section: Claustrocortical Communication Is Increased During Nrem Slee...mentioning

confidence: 99%

“…The time-lag at maximum correlation underwent a positive shift between wake and NREM indicating that claustrum activity was more correlated with increases in future delta frequency amplitude during NREM relative to wake (Figure 3C). Therefore, claustrum activity is more likely to participate in shaping the dynamics of ongoing delta wave fluctuations during NREM, whereas the cortex may be responsible for shaping claustrum activity during wakefulness.Changes in behavioral state also impact the efficacy of synaptic transmission 55,56 and sensory responses in the cortex 22,51,[57][58][59][60] . Previously it was noted that claustrum activation is less effective during active wake 7,41,45 , but this has not been systematically measured.…”

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confidence: 99%

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State dependent constraints on claustrocortical communication and function

Marriott,

Do,

Portet

et al. 2023

Preprint

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Neural activity in the claustrum has been associated with a range of vigilance states, yet the activity 15 patterns and efficacy of synaptic communication of identified claustrum neurons have not been thoroughly determined. Here we show that claustrum neurons projecting to the retrosplenial cortex were most active during synchronized cortical states such as non-rapid-eye-movement (NREM) sleep and were suppressed during increased cortical desynchronization in arousal, movement, and REM sleep. The efficacy of claustrocortical signaling was also increased during NREM and diminished during movement due in part to increased cholinergic tone. Finally, claustrum activation during NREM sleep enhanced memory consolidation through the phase-resetting of cortical delta waves. Therefore, claustrocortical communication is constrained to function most effectively during cognitive processes associated with synchronized cortical states, such as memory consolidation.

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Section: Claustrocortical Communication Is Increased During Nrem Slee...mentioning

confidence: 99%

mentioning

confidence: 99%

State dependent constraints on claustrocortical communication and function

Marriott,

Do,

Portet

et al. 2023

Preprint

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“…Together these studies support a sleep-dependent, sensory gate in olfaction, though with some variability between studies. In fact, optogenetic stimulation of olfactory sensory neurons during different vigilance states in mice suggests a lack of state-dependent gating as far as the anterior piriform cortex and orbitofrontal cortex—the latter of which receives both direct and indirect input from the anterior piriform cortex ( Schreck et al, 2022 ). Schreck et al (2022) , suggesting that the reduced odor evoked activity during sleep seen in other paradigms may not be due to central sensory gating, but rather related to changes in respiration during sleep, which could reduce stimulus access to the receptors.…”

Section: Sleep and Sensory Processing Across Systemsmentioning

confidence: 99%

Reciprocal relationships between sleep and smell

Gaeta¹,

Wilson

2022

Front. Neural Circuits

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Despite major anatomical differences with other mammalian sensory systems, olfaction shares with those systems a modulation by sleep/wake states. Sleep modulates odor sensitivity and serves as an important regulator of both perceptual and associative odor memory. In addition, however, olfaction also has an important modulatory impact on sleep. Odors can affect the latency to sleep onset, as well as the quality and duration of sleep. Olfactory modulation of sleep may be mediated by direct synaptic interaction between the olfactory system and sleep control nuclei, and/or indirectly through odor modulation of arousal and respiration. This reciprocal interaction between sleep and olfaction presents novel opportunities for sleep related modulation of memory and perception, as well as development of non-pharmacological olfactory treatments of simple sleep disorders.

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“…Sleep was characterized by high-amplitude, low-frequency EEG oscillations in the delta range (0.5–4 Hz) and low EMG activity as previously described. 62 …”

Section: Methodsmentioning

confidence: 99%

“…Sleep classification was performed using a combination of EEG and EMG signals. 62 EEG spectrograms of the 0–15 Hz range were determined using multitaper methods from the Chronux toolbox with a moving window of 0.5 s. First NREM sleep was characterized by high-amplitude, low-frequency EEG oscillations in the delta range (0.5–4 Hz) and low EMG activity, whereas REM sleep was defined by EEG oscillations in the theta range (6–8 Hz) and even further reduced EMG. Wake was characterized by low-amplitude, fast EEG oscillations and high EMG activity.…”

Section: Methodsmentioning

confidence: 99%