State-dependent learning

Poling, Alan; Cross, Jeffrey D.

doi:10.1016/b978-0-444-81444-9.50015-8

Cited by 6 publications

(6 citation statements)

References 23 publications

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“…It is possible that performance under the spatial alternation task is state dependent; changing the interoceptive stimuli through drug administration may therefore result in changes in performance. [For a further discussion of state-dependent learning, see Poling and Cross (1993)]. This may not be the case here, however, in that under a similar schedule of delayed alternation, the convulsant picrotoxin did not disrupt alternation responding by rats up to doses that greatly increased response latencies (unpublished observations).…”

Section: Discussionmentioning

confidence: 56%

Effects of drugs of abuse and scopolamine on memory in rats: delayed spatial alternation and matching to position

1998

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Drugs of abuse produce amnestic effects in humans and laboratory animals in a variety of tasks. Generally, only a few compounds have been examined in any particular procedure. It was the goal of the present studies to examine drugs of abuse of different pharmacological classes in rats responding under two behavioral schedules historically employed as experimental models of memory: spatial alternation and matching to position. One group of rats responded under a single-response spatial-alternation baseline with a 10-s delay and another group responded under a matching-to-position baseline with delay values of 3, 10 and 30 s. Performance under the spatial-alternation baseline was characterized by low variability and >90% accuracy. Under the matching-to-position baseline, saline control percent accuracy was >95% at 3 s, >85% at 10 s and >70% at 30 s. Under spatial alternation cocaine, d-amphetamine, pentobarbital, diazepam, phencyclidine, scopolamine and methscopolamine produced significant (P<0.05) effects on accuracy, whereas only cocaine, d-amphetamine, pentobarbital and phencyclidine disrupted accuracy under the matching-to-position baseline. These results suggest that spatial alternation may be a more sensitive baseline for determining drug effects on working memory in the rat.

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Section: Discussionmentioning

confidence: 56%

Effects of drugs of abuse and scopolamine on memory in rats: delayed spatial alternation and matching to position

1998

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“…(a) these proteins contribute to sequestration of (Overton, 1974;Poling & Cross, 1993). There is some evidence to suggest that trace and context fear memory can be modified in a state-dependent manner rather than through a change in mnemonic processes (Hunt & Barnet, 2016;Jovasevic et al, 2015;Reich, Mohammadi, & Alger, 2008).…”

Section: Aq Infusion Differentially Modulates Fear Memory Deficits mentioning

confidence: 99%

Apoaequorin differentially modulates fear memory in adult and aged rats

2020

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“…With the advent, in the 1970s, of the DD paradigm, studies of StD have largely been abandoned (Poling and Cross 1993; see also Eich 1980), and DD has since been developed into what is currently one of the most powerful techniques of behavioral neuropharmacology (e.g., Ho et al 1978;Colpaert and Slangen 1982;Colpaert 1986a;Jfirbe 1986;Samele et al 1992). One assumption underlying this shift from StD to DD has been that the two paradigms are conceptually equivalent; researchers have been virtually unanimous in accepting this assumption (Dews 1975;J/irbe 1986;Kuhn et al 1976;Schuster and Balster 1977;Barry and Krimmer 1978a;Schechter 1978;Overton 1982Overton , 1983Overton , 1985see also Chute 1978;Poling and Cross 1993). It has been argued, however, that the StD and DD paradigms differ in the stimulus properties of drugs which they measure, and may therefore generate different outcomes reflecting different neurobiological phenomena (Colpaert et al 1976;Colpaert 1977a, b).…”

Section: Introductionmentioning

confidence: 99%

Empirical evidence that the state dependence and drug discrimination paradigms can generate different outcomes

Colpaert

Koek

1995

Psychopharmacology

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The study compared the outcomes generated by the State Dependence and Drug Discrimination paradigms with ethanol in the rat. Food-deprived rats learned to complete a fixed-ratio 10 schedule of bar presses for food within 120 s while treated with 320- to 1250-mg/kg doses of ethanol. Subsequent tests of recall of this response with saline failed to generate any evidence that transfer was hampered following the drug-to-saline state change. In contrast, each of 14 rats learned to discriminate 1250 mg/kg ethanol from saline in a Drug Discrimination procedure that also required the animals to press one of two levers for food according to a fixed- ratio 10 schedule. The results offer the first empirical evidence to demonstrate directly that the State Dependence and Drug Discrimination paradigms can generate different outcomes in otherwise identical experimental conditions.

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State-dependent learning

Cited by 6 publications

References 23 publications

Effects of drugs of abuse and scopolamine on memory in rats: delayed spatial alternation and matching to position

Effects of drugs of abuse and scopolamine on memory in rats: delayed spatial alternation and matching to position

Apoaequorin differentially modulates fear memory in adult and aged rats

Empirical evidence that the state dependence and drug discrimination paradigms can generate different outcomes

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