State-Dependent Differences in Emotion Regulation Between Unmedicated Bipolar Disorder and Major Depressive Disorder

Rive, Maria M.; Mocking, Roel J. T.; Koeter, Maarten W. J.; Wingen, Guido van; Wit, Stella J. de; Heuvel, Odile A. van den; Veltman, Dick J.; Ruhé, Henricus G.; Schene, Aart H.

doi:10.1001/jamapsychiatry.2015.0161

Cited by 79 publications

(80 citation statements)

References 71 publications

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“…Compared to MDD patients, BD patients show significantly stronger functional connectivity within the dorsolateral PFC and ventrolateral PFC, as well as inferior frontal/dorsolateral PFC to ACC (68), suggesting that changes in functional connectivity between the ACC and PFC, as well as differences in Glu neurotransmission within the ACC, may differentiate the two disorders. This is supported by studies that compared BD and MDD patients and found differences in PFC activation during emotionally-laden tasks (69). …”

Section: Functional Circuitry Abnormalities In Depressionmentioning

confidence: 55%

Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine

Lener

Niciu

Ballard

et al. 2017

Biological Psychiatry

373

214

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In patients with major depressive disorder (MDD) or bipolar disorder (BD), abnormalities in excitatory and/or inhibitory neurotransmission and neuronal plasticity may lead to aberrant functional connectivity patterns within large brain networks. Network dysfunction in association with altered brain levels of glutamate (Glu) and gamma-aminobutyric acid (GABA) have been identified in both animal and human studies of depression. In addition, evidence of an antidepressant response to subanesthetic dose ketamine has led to a collection of studies that have examined neurochemical (e.g. glutamatergic and GABA-ergic) and functional imaging correlates associated with such an effect. Results from these studies suggest that an antidepressant response in association with ketamine occurs, in part, by reversing these neurochemical/physiological disturbances. Future studies in depression will require a combination of neuroimaging approaches from which more biologically homogeneous subgroups can be identified, particularly with respect to treatment response biomarkers of glutamatergic modulation.

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Section: Functional Circuitry Abnormalities In Depressionmentioning

confidence: 55%

Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine

Lener

Niciu

Ballard

et al. 2017

Biological Psychiatry

373

214

View full text Add to dashboard Cite

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“…While there were no significant differences in emotion regulation between remitted MDD and HC, remitted BD showed impaired emotion regulation corresponding with an increased activity in frontal regions in remitted BD compared to remitted MDD (Rive et al, ). Our results regarding higher measures of centrality in conjunction with lower nodal PL in frontal areas may be the GT‐correlate of previous findings distinguishing symptomless BD and MDD as conducted by Rive et al (). We thus reinforce their proposition that impairments of emotion processing persist in BD but less in MDD during remission.…”

Section: Discussionmentioning

confidence: 99%

Aberrant brain network topology in fronto‐limbic circuitry differentiates euthymic bipolar disorder from recurrent major depressive disorder

et al. 2019

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Introduction Previous studies have established graph theoretical analysis of functional network connectivity (FNC) as a potential tool to detect neurobiological underpinnings of psychiatric disorders. Despite the promising outcomes in studies that examined FNC aberrancies in bipolar disorder (BD) and major depressive disorder (MDD), there is still a lack of research comparing both mood disorders, especially in a nondepressed state. In this study, we used graph theoretical network analysis to compare brain network properties of euthymic BD, euthymic MDD and healthy controls (HC) to evaluate whether these groups showed distinct features in FNC. Methods We collected resting‐state functional magnetic resonance imaging (fMRI) data from 20 BD patients, 15 patients with recurrent MDD as well as 30 age‐ and gender‐matched HC. Graph theoretical analyses were then applied to investigate functional brain networks on a global and regional network level. Results Global network analysis revealed a significantly higher mean global clustering coefficient in BD compared to HC. We further detected frontal, temporal and subcortical nodes in emotion regulation areas such as the limbic system and associated regions exhibiting significant differences in network integration and segregation in BD compared to MDD patients and HC. Participants with MDD and HC only differed in frontal and insular network centrality. Conclusion In conclusion, our findings indicate that a significantly altered brain network topology in the limbic system might be a trait marker specific to BD. Brain network analysis in these regions may therefore be used to differentiate euthymic BD not only from HC but also from patients with MDD.

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“…And several task-fMRI studies also found increased activity in the DLPFC during suppression of negative emotions (Lévesque et al, 2003, Phan et al, 2005). Rive et al (2015) investigated emotion regulation in patients with MDD and BD using task-fMRI and found that the BD patients had more seriously impaired emotion regulation. Additionally, they showed increased DLPFC activity in the BD patients compared to the MDD patients and healthy controls in an emotion regulation task, particularly in the sad emotion regulation task.…”

Section: Discussionmentioning

confidence: 99%

Common and Specific Abnormalities in Cortical Thickness in Patients with Major Depressive and Bipolar Disorders

et al. 2017

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Major depressive disorder (MDD) and bipolar disorder (BD) are severe psychiatric diseases with overlapping symptomatology. Although previous studies reported abnormal brain structures in MDD or BD patients, the disorder-specific underlying neural mechanisms remain poorly understood. The purpose of this study was to investigate the whole-brain gray matter morphological patterns in unmedicated patients with MDD or BD and to identify the shared and disease-specific brain morphological alterations in these two disorders.We acquired high-resolution brain structural MRI data from a sample of 36 MDD patients, 32 BD patients, and 30 healthy controls. Using FreeSurfer, we estimated their brain cortical thickness (CT) and compared between-group difference in multiple locations across the continuous cortical surface.Compared to the healthy controls, both the MDD and BD patient groups showed significantly reduced CT in the left inferior temporal cortex (ITC). However, compared to the MDD patients, the BD patients showed a significantly thinner CT in the left rostral middle frontal region. In addition, compared to the healthy controls, the BD patients displayed thinner CT in the left ITC, left frontal pole (FPO), left superior frontal, right lateral occipital, right pars triangularis (PTRI) and right lateral orbitofrontal regions. Further analysis revealed a significantly positive correlation between the mean CT in the left FPO and the onset age, but a negative correlation between the mean CT in the right PTRI and the number of episodes, in the BD patients.Our findings revealed that the BD and MDD patients had variations in CT that were in common, but many more that were distinct, suggesting potential differences in their neural mechanisms.

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State-Dependent Differences in Emotion Regulation Between Unmedicated Bipolar Disorder and Major Depressive Disorder

Cited by 79 publications

References 71 publications

Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine

Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine

Aberrant brain network topology in fronto‐limbic circuitry differentiates euthymic bipolar disorder from recurrent major depressive disorder

Common and Specific Abnormalities in Cortical Thickness in Patients with Major Depressive and Bipolar Disorders

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