State-dependent activity of neurons in the perifornical hypothalamic area during sleep and waking

Koyama, Yoshimasa; Takahashi, Kazumi; Kodama, Tohru; Kayama, Yukihiko

doi:10.1016/s0306-4522(03)00173-8

Cited by 95 publications

(81 citation statements)

References 54 publications

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“…In agreement with previous PF/LH unit activity studies Koyama et al, 2003), the examined cells were heterogeneous in terms of their sleep-wake discharge profiles. Based on the results of cluster analysis followed by evaluation of staterelatedness for each member of the cluster, PF/LH cells were subdivided into five groups designated in accordance with the state(s) in which unit discharge was the highest, namely: AW/REM sleep-related, AW-related, NREM/REM sleep-related, REM sleep-related, and state-indifferent neurons.…”

Section: Pf/lh Neurons: Sleep-wake Discharge Patterns and Responses Tsupporting

confidence: 91%

“…As in previous studies of PF/LH region Koyama et al, 2003), we found AW-related, AW/REM sleeprelated, REM sleep-related, and state-indifferent cells. In addition, we identified a new group of NREM/REM sleep-related neurons.…”

Section: Sleep-wake Discharge Profiles Of Pf/lh Neuronssupporting

confidence: 89%

“…The majority of PF/LH neurons, including hypocretin cells, exhibit increased neuronal discharge and c-Fos immunoreactivity during active waking (AW) compared with quiet waking (QW) and non-rapid eye movement (NREM) sleep (Estabrooke et al, 2001;Torterolo et al, 2001;Koyama et al, 2003;Lee et al, 2005;Mileykovskiy et al, 2005). Current evidence suggests a role of GABAergic inhibition in the sleep-related inactivation of arousal-related PF/LH neurons and involvement of this mechanism in sleep control.…”

Section: Introductionmentioning

confidence: 99%

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The Median Preoptic Nucleus Reciprocally Modulates Activity of Arousal-Related and Sleep-Related Neurons in the Perifornical Lateral Hypothalamus

Suntsova¹,

Guzmán-Marı́n²,

Kumar³

et al. 2007

J. Neurosci.

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Section: Pf/lh Neurons: Sleep-wake Discharge Patterns and Responses Tsupporting

confidence: 91%

Section: Sleep-wake Discharge Profiles Of Pf/lh Neuronssupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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The Median Preoptic Nucleus Reciprocally Modulates Activity of Arousal-Related and Sleep-Related Neurons in the Perifornical Lateral Hypothalamus

Suntsova¹,

Guzmán-Marı́n²,

Kumar³

et al. 2007

J. Neurosci.

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“…Orexin neurons are located in the perifornical lateral hypothalamus and project to most brain areas (Peyron et al, 1998), and in particular to the brainstem aminergic and cholinergic nuclei. Orexin neurons are thus likely to regulate vigilance states (Nishino, 2003): they fire at high rates during wakefulness and low rates during REM sleep (Koyama et al, 2003;Mileykovskiy et al, 2005). The orexin neurons also regulate somatomotor control, feeding, and energy balance (Nishino, 2003;Okumura et al, 2001;Sakurai et al, 2002).…”

Section: Orexinergic Modulation Of Locomotion and Postural Muscle Tonementioning

confidence: 99%

“…Because of lower orexin and monoamine levels (Koyama et al, 2003;Siegel, 2004), the excitability of the muscle tone inhibitory system would be higher. A higher limbic activity in a normal REM sleep period may thus preferentially excite this system, and result in muscular atonia.…”

Section: Implications Of Pathophysiological Mechanisms Of Narcolepsymentioning

confidence: 99%

Forebrain control of locomotor behaviors

Takakusaki

2008

Brain Research Reviews

129

120

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Activation of different areas in the forebrain evokes different types of goal directed adaptive behaviors. An important component of these different patterns of behavior is the locomotion that brings the animal to or away from a particular location.Here I review the role of projections from forebrain structures to the mesopontine tegmentum of the brainstem where neural mechanisms for initiation of locomotion and regulation of postural muscle tone are located that are activated during locomotor behavior. It is interesting is to understand how signals that converge from the forebrain structures to the mesopontine tegmentum control locomotor behavior, because the mesopontine tegmentum receives inhibitory efferents from the basal ganglia and excitatory efferents from the limbic-hypothalamic system and the neocortex. Here I hypothesize that the mesopontine tegmentum has functional gating mechanisms that determine whether the subject will initiate and select volitionally-guided or emotionally-triggered locomotor behaviors, depending on the behavioral context.

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Vesicular glutamate (VGlut), GABA (VGAT), and acetylcholine (VACht) transporters in basal forebrain axon terminals innervating the lateral hypothalamus

Henny

Jones

2006

J of Comparative Neurology

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The basal forebrain (BF) is known to play important roles in cortical activation and sleep, which are likely mediated by chemically differentiated cell groups including cholinergic, gamma-aminobutyric acid (GABA)ergic and other unidentified neurons. One important target of these cells is the lateral hypothalamus (LH), which is critical for arousal and the maintenance of wakefulness. To determine whether chemically specific BF neurons provide an innervation to the LH, we employed anterograde transport of 10,000 MW biotinylated dextran amine (BDA) together with immunohistochemical staining of the vesicular transporter proteins (VTPs) for glutamate (VGluT1, -2, and -3), GABA (VGAT), or acetylcholine (ACh, VAChT). In addition, we applied triple staining for the postsynaptic proteins (PSPs), PSD-95 with VGluT or Gephyrin (Geph) with VGAT, to examine whether the BDA-labeled varicosities may form excitatory or inhibitory synapses in the LH. Axons originating from BDA-labeled neurons in the magnocellular preoptic nucleus (MCPO) and substantia innominata (SI) descended within the medial forebrain bundle and extended collateral varicose fibers to contact LH neurons. In the LH, the BDA-labeled varicosities were immunopositive (+) for VAChT ( approximately 10%), VGluT2 ( approximately 25%), or VGAT ( approximately 50%), revealing an important influence of newly identified glutamatergic together with GABAergic BF inputs. Moreover, in confocal microscopy, VGluT2+ and VGAT+ terminals were apposed to PSD-95+ and Geph+ profiles respectively, indicating that they formed synaptic contacts with LH neurons. The important inputs from glutamatergic and GABAergic BF cells could thus regulate LH neurons in an opposing manner to stimulate vs. suppress cortical activation and behavioral arousal reciprocally.

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State-dependent activity of neurons in the perifornical hypothalamic area during sleep and waking

Cited by 95 publications

References 54 publications

The Median Preoptic Nucleus Reciprocally Modulates Activity of Arousal-Related and Sleep-Related Neurons in the Perifornical Lateral Hypothalamus

The Median Preoptic Nucleus Reciprocally Modulates Activity of Arousal-Related and Sleep-Related Neurons in the Perifornical Lateral Hypothalamus

Forebrain control of locomotor behaviors

Vesicular glutamate (VGlut), GABA (VGAT), and acetylcholine (VACht) transporters in basal forebrain axon terminals innervating the lateral hypothalamus

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