State birth defects surveillance programs directory

Ld, Edmonds

doi:10.1002/(sici)1096-9926(199707/08)56:1/2<63::aid-tera10>3.0.co;2-u

Cited by 6 publications

(1 citation statement)

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“…Data were obtained from the Hawaii Birth Defects Program (HBDP), an active, population‐based birth defects registry for the state of Hawaii 5 . All pregnancy outcomes are included regardless of gestational age at delivery.…”

Section: Methodsmentioning

confidence: 99%

Epidemiology of holoprosencephaly in Hawaii, 1986–97

Forrester¹,

Merz²

2000

Paediatric Perinatal Epid

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Holoprosencephaly is a birth defect affecting the medial structures of the brain and face. This investigation examined the epidemiology of holoprosencephaly in Hawaii between 1986 and 1997, using data obtained from a birth defects registry, and compared the results with those of other population-based studies. Twenty-five cases were identified, producing a prevalence of 1.09 per 10,000 livebirths. There were 17 (68.0%) livebirths, two (8.0%) fetal deaths and six (24.0%) elective terminations. Ten (58.8%) of the livebirths died before the age of 1 year. Seven (28.0%) had a known chromosomal abnormality, most often trisomy 13. Prevalence rates were higher for maternal age > 39 years, maternal race/ethnicity of Far East Asian or Filipino, females and residence in Maui County. The small number of cases limited the statistical significance of the study. However, this report confirms many of the findings from the previous studies and adds new findings, particularly the higher prevalence among Far East Asians and Filipinos.

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Section: Methodsmentioning

confidence: 99%

Epidemiology of holoprosencephaly in Hawaii, 1986–97

Forrester¹,

Merz²

2000

Paediatric Perinatal Epid

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Epidemiology of abdominal wall defects, Hawaii, 1986-1997

Forrester¹,

Merz²

1999

Teratology

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The various types of abdominal wall defects are considered to differ in their etiologies, a hypothesis suggested by differences in their epidemiologies. This study examined the impact of selected demographic factors on abdominal wall defects (omphalocele, gastroschisis, and body stalk anomaly) included in a birth defects registry in Hawaii from 1986–1997. The total prevalence for the various defects were: omphalocele (2.76 per 10,000 births, 95% confidence interval (CI), 2.14–3.50), gastroschisis (3.01, 95% CI, 2.36–3.77), and body stalk anomalies (0.32, 95% CI, 0.14–0.64). The prevalence increased over the 12‐year period for both omphalocele (P = 0.052) and gastroschisis (P = 0.008). Women less than age 20 were at increased risk for a gastroschisis‐affected pregnancy, while those age 40 and over were disproportionately more likely to have an omphalocele‐affected pregnancy. Pacific Islanders had the lowest risk for omphalocele, whereas Far East Asians were least likely to have gastroschisis. Omphalocele rates were lower outside metropolitan Honolulu, while place of residence did not significantly impact gastroschisis risk. The 1‐year survival rate was higher for gastroschisis than for omphalocele (88.5% and 70.7%, respectively), while none of the infants with body stalk anomalies was live‐born. The results of this study tend to support the hypothesis of differing etiologies for the studied abdominal wall defects. Teratology 60:117–123, 1999. © 1999 Wiley‐Liss, Inc.

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