STAT3 Regulates miR-384 Transcription During Th17 Polarization

Han, Jingjing; Liu, Yaping; Zhen, Fei; Yuan, Wen; Zhang, Wei; Song, Xiaotao; Dong, Fuxing; Yao, Ruiqin; Qu, Xuebin

doi:10.3389/fcell.2019.00253

Cited by 6 publications

(4 citation statements)

References 53 publications

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“…Gene promoter sequences (2000 bp upstream of the start site) were extracted from the genome of Moso bamboo. The JASPAR database ( http://jaspar.genereg.net/ ) was used to predict the binding site genes of PeBBX [ 96 ]. The screening index was set to less than 1.0 E − 6 to identify the genes targeted by BBX members.…”

Section: Methodsmentioning

confidence: 99%

The BBX gene family in Moso bamboo (Phyllostachys edulis): identification, characterization and expression profiles

Chen

Huang

et al. 2021

BMC Genomics

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Background The BBX (B-box) family are zinc finger protein (ZFP) transcription factors that play an essential role in plant growth, development and response to abiotic stresses. Although BBX genes have been characterized in many model organisms, genome-wide identification of the BBX family genes have not yet been reported in Moso bamboo (Phyllostachys edulis), and the biological functions of this family remain unknown. Result In the present study, we identified 27 BBX genes in the genome of Moso bamboo, and analysis of their conserved motifs and multiple sequence alignments revealed that they all shared highly similar structures. Additionally, phylogenetic and homology analyses indicated that PeBBX genes were divided into three clusters, with whole-genome duplication (WGD) events having facilitated the expansion of this gene family. Light-responsive and stress-related cis-elements were identified by analyzing cis-elements in the promoters of all PeBBX genes. Short time-series expression miner (STEM) analysis revealed that the PeBBX genes had spatiotemporal-specific expression patterns and were likely involved in the growth and development of bamboo shoots. We further explored the downstream target genes of PeBBXs, and GO/KEGG enrichment analysis predicted multiple functions of BBX target genes, including those encoding enzymes involved in plant photosynthesis, pyruvate metabolism and glycolysis/gluconeogenesis. Conclusions In conclusion, we analyzed the PeBBX genes at multiple different levels, which will contribute to further studies of the BBX family and provide valuable information for the functional validation of this family.

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Section: Methodsmentioning

confidence: 99%

The BBX gene family in Moso bamboo (Phyllostachys edulis): identification, characterization and expression profiles

Chen

Huang

et al. 2021

BMC Genomics

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“…Furthermore, it has been shown that granulocyte-macrophage CSF (GM-CSF) and TNF-α can respectively reduce the expression/production of hsa-miR-223 and hsa-miR-138 [155] , [200] ( Table 1 ). It has also been reported that upregulated activation of STAT3 in the experimental autoimmune encephalomyelitis (EAE) model is accompanied by a higher expression level of hsa-miR-384 resulting in increased differentiation of Th17 lymphocytes [201] ( Table 1 ). As mentioned in part 7.1, some target mRNAs can degrade the corresponding hsa-miRNAs [189] , [190] ( Table 1 ).…”

Section: Hsa-mirnas and Sars-cov-2-induced Interfering Factorsmentioning

confidence: 98%

Cytokine storm in the pathophysiology of COVID-19: Possible functional disturbances of miRNAs

Aslani

Mortazavi-Jahromi

Mirshafiey

2021

International Immunopharmacology

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SARS-CoV-2, as the causative agent of COVID-19, is an enveloped positives-sense single-stranded RNA virus that belongs to the Beta-CoVs sub-family. A sophisticated hyper-inflammatory reaction named cytokine storm is occurred in patients with severe/critical COVID-19, following an imbalance in immune-inflammatory processes and inhibition of antiviral responses by SARS-CoV-2, which leads to pulmonary failure, ARDS, and death. The miRNAs are small non-coding RNAs with an average length of 22 nucleotides which play various roles as one of the main modulators of genes expression and maintenance of immune system homeostasis. Recent evidence has shown that Homo sapiens (hsa)-miRNAs have the potential to work in three pivotal areas including targeting the virus genome, regulating the inflammatory signaling pathways, and reinforcing the production/signaling of IFNs-I. However, it seems that several SARS-CoV-2-induced interfering agents such as viral (v)-miRNAs, cytokine content, competing endogenous RNAs (ceRNAs), etc. preclude efficient function of hsa-miRNAs in severe/critical COVID-19. This subsequently leads to increased virus replication, intense inflammatory processes, and secondary complications development. In this review article, we provide an overview of hsa-miRNAs roles in viral genome targeting, inflammatory pathways modulation, and IFNs responses amplification in severe/critical COVID-19 accompanied by probable interventional factors and their function. Identification and monitoring of these interventional elements can help us in designing the miRNAs-based therapy for the reduction of complications/mortality rate in patients with severe/critical forms of the disease.

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“…Interestingly, IL-6-mediatated activation of STAT3 strongly induces miR-183-96-182 expression, which in turn inhibits FOXO1 in pathogenic Th17 cells. Similarly, STAT3 activation mediates the induction of miR-384 in CD4 + T cells, which reduces the expression of SOCS3, elevates the Th17/Treg ratio, and aggravates inflammation in EAE (43,81). One final example of a positive regulation of Th17 cell differentiation by miRNA is the miR-132/212 cluster.…”

Section: Mirnas In Msmentioning

confidence: 99%

miRNAs Alter T Helper 17 Cell Fate in the Pathogenesis of Autoimmune Diseases

Huang

Yang

2021

Front. Immunol.

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T helper 17 (Th17) cells are characterized by the secretion of the IL-17 cytokine and are essential for the immune response against bacterial and fungal infections. Despite the beneficial roles of Th17 cells, unrestrained IL-17 production can contribute to immunopathology and inflammatory autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. Although these diverse outcomes are directed by the activation of Th17 cells, the regulation of Th17 cells is incompletely understood. The discovery that microRNAs (miRNAs) are involved in the regulation of Th17 cell differentiation and function has greatly improved our understanding of Th17 cells in immune response and disease. Here, we provide an overview of the biogenesis and function of miRNA and summarize the role of miRNAs in Th17 cell differentiation and function. Finally, we focus on recent advances in miRNA-mediated dysregulation of Th17 cell fate in autoimmune diseases.

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STAT3 Regulates miR-384 Transcription During Th17 Polarization

Cited by 6 publications

References 53 publications

The BBX gene family in Moso bamboo (Phyllostachys edulis): identification, characterization and expression profiles

The BBX gene family in Moso bamboo (Phyllostachys edulis): identification, characterization and expression profiles

Cytokine storm in the pathophysiology of COVID-19: Possible functional disturbances of miRNAs

miRNAs Alter T Helper 17 Cell Fate in the Pathogenesis of Autoimmune Diseases

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