STAT3 Polymorphism Can Predict the Response to Interferon-α Therapy in Patients with Metastatic Renal Cell Carcinoma

STAT3 polymorphisms may predict an unfavorable response to first‐line platinum‐based therapy for women with advanced serous epithelial ovarian cancer

“…A G>C SNP in the 5′ region of STAT3 (rs4796793) was the most significant predictor of a favorable response to interferon-a therapy in patients with metastatic renal cell carcinoma. 19,20 rs4796793 C allele carriers, which were observed more frequently among IFN-α responders, tended to have lower STAT3 expression in their matched tumor tissue. rs4796793 was not a top-ranked SNP in our dataset.…”

Association of Single Nucleotide Polymorphisms in STAT3 with Hand-Foot Skin Reactions in Patients with Metastatic Renal Cell Carcinoma Treated with Multiple Tyrosine Kinase Inhibitors: A Retrospective Analysis in Japanese Patients

“…Associations between STAT3 polymorphisms and various diseases and drug responses have been reported in the Japanese population [11][12][13][14]. Although the functions of many of these polymorphisms are unknown, rs4796793 is known to affect the STAT3 mRNA expression levels in B lymphocyte cell lines as a consequence of its location in the 5′-flanking region of STAT3 [12].…”

“…In addition, functional single nucleotide polymorphisms (SNPs) in STAT3 have recently been reported in the Japanese literature [11][12][13][14]. The STAT3 polymorphism in particular was found to be a reliable predictor of IFN (interferon)-α therapeutic outcomes in patients with mRCC [11,12], suggesting a potential association between STAT3 polymorphisms and development of mTKIinduced HFSR.…”

“…STAT3 is a point of convergence for the signaling pathways downstream of numerous cytokine receptors or tyrosine kinases, including vascular endothelial growth factor receptor, platelet-derived growth factor receptor, epidermal growth factor receptor, and Src [7,8], and plays a critical role in various biological activities, including the regulation of cutaneous homeostasis [7][8][9][10]. In addition, functional single nucleotide polymorphisms (SNPs) in STAT3 have recently been reported in the Japanese literature [11][12][13][14]. The STAT3 polymorphism in particular was found to be a reliable predictor of IFN (interferon)-α therapeutic outcomes in patients with mRCC [11,12], suggesting a potential association between STAT3 polymorphisms and development of mTKIinduced HFSR.…”

Association of Single Nucleotide Polymorphism rs1053004 in Signal Transducer and Activator of Transcription 3 (STAT3) with Susceptibility to Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B

“…Moreover, previous studies indicated that STAT3 can be activated by the X protein of HBV and activated STAT3 can also bind with the HBV enhancer 1 to activate gene expression, suggesting the interplay between STAT3 and X protein in promoting HCC development (Waris and Siddiqui, 2002). In addition to the functions of STAT3 and HBV infection, several lines of evidence have indicated that single nucleotide polymorphisms (SNPs) in STAT3 gene are associated with susceptibility to malignant development or response to therapy in several types of cancer such as cervical, gastric and renal cancers (Wang et al, 2011;Eto et al, 2013;Yuan et al, 2014). Along with the above-mentioned evidences, it would be interested that the SNPs in STAT3 gene may potentially contribute to the susceptibility of HCC.…”