“…As an extreme example, two patients harbored four different STAT3 mutations (Figure 1). Patients with multiple STAT3 mutations could be divided into two different groups based on the allelic status derived from the amplicon data: (i) patients harboring two single nucleotide variants in the same STAT3 allele, resulting in one or two amino acid changes (n=4, Figure 1, patients 1-4), and (ii) patients displaying multiple STAT3 mutations in different alleles and lymphocyte clones (n=14, Figure 1, patients [5][6][7][8][9][10][11][12][13][14][15][16][17][18] …”