Stasis Dermatitis: Pathophysiology, Evaluation, and Management

Sundaresan, Swaminathan; Migden, Michael R.; Silapunt, Sirunya

doi:10.1007/s40257-016-0250-0

Cited by 90 publications

(159 citation statements)

References 61 publications

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“…Among the patients who received EGFR‐TKIs, only a small number presented with purpuric drug eruptions . We hypothesized that purpuric drug eruptions may be associated with multiple risk factors including genetic predisposition , bacterial infection , sex , age , and venous insufficiency . In our previous study, 75% of patients suffering from purpuric drug eruptions were female and 19% of patients had leg edema .…”

Section: Discussionmentioning

confidence: 99%

Purpuric drug eruptions induced by EGFR tyrosine kinase inhibitors are associated with IQGAP1‐mediated increase in vascular permeability

Sheen

Lin

Tzeng

et al. 2020

The Journal of Pathology

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Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) are used as a treatment for non‐small‐cell lung cancer. There have been some reports of EGFR‐TKIs being associated with vascular adverse events. We found that EGFR‐TKIs decreased the proliferation of HMEC‐1s (immortalized human dermal microvascular endothelial cells) and HMVECs (human dermal microvascular endothelial cells), and also inhibited the phosphorylation of EGFR and ERK. We examined the mRNA expression profile of erlotinib‐treated HMEC‐1s and identified IQ motif containing GTPase activating protein 1 (IQGAP1) as the most consistently up‐regulated transcript and protein. IQGAP1 was also overexpressed and co‐localized with endothelial cells in the lesional skin. Notably, increased IQGAP1 expression was associated with decreased transendothelial electrical resistance and increased vascular permeability in vitro. Erlotinib treatment enriched the staining of IQGAP1 and reduced the intensities of α‐catenin at the sites of cell–cell contact. In conclusion, erlotinib induces adherens junction dysfunction by modulating the expression of IQGAP1 in dermal endothelial cells. © 2020 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Purpuric drug eruptions induced by EGFR tyrosine kinase inhibitors are associated with IQGAP1‐mediated increase in vascular permeability

Sheen

Lin

Tzeng

et al. 2020

The Journal of Pathology

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“…We found stasis dermatitis in 5.7% of patients. Stasis dermatitis is also most common in people > 50 years old with an overall disease prevalence of 6 -7% 49 . Urticaria was found in 4.8% of the study participants.…”

Section: Discussionmentioning

confidence: 99%

Association between skin manifestations and glycemic control in patients with diabetes mellitus type II

2021

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Background/Aim. Diabetes mellitus can be associated with numerous skin diseases. This study aimed to determine the pattern and incidence of skin manifestations in patients with diabetes mellitus type II and their link to glycemic control. Methods. Prospective cross-sectional study was conducted at the Skin and Venereal Diseases Clinic, University Clinical Centre of the Republic of Srpska in Banja Luka, Bosnia and Herzegovina from January 2016 to January 2018. Adult patients of both genders suffering from diabetes mellitus type II and cutaneous manifestations participated in the study. Glycemic control was assessed according to values of glycated hemoglobin (HbA1c) of 7%. Results. Mean age of 105 study participants (46% male and 54% female) was 68.4 ± 10 years while mean HbA1c was 8.3 ± 1.6%. Unsatisfactory glycemic control was found in 74.3% of patients with mean HbA1c at 8.9 ± 1.4% while satisfactory glycemic control was found in 25.7% of patients with mean HbA1c at 6.7 ± 0.2% (p < 0.001). Most frequent skin diseases were infections (43.9%). Bacterial infections were most common (26.7%) followed by fungal infections (24.8%), xerosis (17.1%), psoriasis (15.2%), fibroma molle (14.3%), diabetic ulcer (7.7%), prurigo (6.7%), stasis dermatitis (5.7%). Other skin manifestations were found at a lower rate. Major link was found between unsatisfactory glycemic control and skin infections (p = 0.009). Conclusion. Most common skin manifestations in patients with diabetes type II are infections. Skin infections occurred more often in patients with unsatisfactory glycemic control.

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“…Patients may also have poorly demarcated erythematous plaques on the medial aspects of the lower legs, a common presentation of venous stasis. Venous stasis can inform the dermatologist of an underlying venous incompetency …”

mentioning

confidence: 99%

The importance of vascular disease recognition and patient education in the evaluation of lower extremity wounds in dermatology

2020

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Stasis Dermatitis: Pathophysiology, Evaluation, and Management

Cited by 90 publications

References 61 publications

Purpuric drug eruptions induced by EGFR tyrosine kinase inhibitors are associated with IQGAP1‐mediated increase in vascular permeability

Purpuric drug eruptions induced by EGFR tyrosine kinase inhibitors are associated with IQGAP1‐mediated increase in vascular permeability

Association between skin manifestations and glycemic control in patients with diabetes mellitus type II

The importance of vascular disease recognition and patient education in the evaluation of lower extremity wounds in dermatology

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