Starvation promotes concerted modulation of appetitive olfactory behavior via parallel neuromodulatory circuits

Ko, Kang I; Root, Cory M.; Lindsay, Scott A.; Zaninovich, Orel A.; Shepherd, Andrew K.; Wasserman, Steven A.; Kim, Susy M.; Wang, Jing W.

doi:10.7554/elife.08298

Cited by 166 publications

(216 citation statements)

References 64 publications

(108 reference statements)

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“…Our results suggest that 5-HT may affect TKK mediated gain control differently relative to processes undertaken by other LN populations. Furthermore, the expression of the TKK receptor by ORNs is regulated by hunger, allowing the effects of TKK to vary with behavioral state67. It would be interesting to determine if the expression of 5-HTRs themselves also vary with behavioral state as a means of regulating neuromodulation within the olfactory system.…”

Section: Discussionmentioning

confidence: 99%

Serotonergic Modulation Differentially Targets Distinct Network Elements within the Antennal Lobe of Drosophila melanogaster

Sizemore

Dacks

2016

Sci Rep

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Neuromodulation confers flexibility to anatomically-restricted neural networks so that animals are able to properly respond to complex internal and external demands. However, determining the mechanisms underlying neuromodulation is challenging without knowledge of the functional class and spatial organization of neurons that express individual neuromodulatory receptors. Here, we describe the number and functional identities of neurons in the antennal lobe of Drosophila melanogaster that express each of the receptors for one such neuromodulator, serotonin (5-HT). Although 5-HT enhances odor-evoked responses of antennal lobe projection neurons (PNs) and local interneurons (LNs), the receptor basis for this enhancement is unknown. We used endogenous reporters of transcription and translation for each of the five 5-HT receptors (5-HTRs) to identify neurons, based on cell class and transmitter content, that express each receptor. We find that specific receptor types are expressed by distinct combinations of functional neuronal classes. For instance, the excitatory PNs express the excitatory 5-HTRs, while distinct classes of LNs each express different 5-HTRs. This study therefore provides a detailed atlas of 5-HT receptor expression within a well-characterized neural network, and enables future dissection of the role of serotonergic modulation of olfactory processing.

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Section: Discussionmentioning

confidence: 99%

Serotonergic Modulation Differentially Targets Distinct Network Elements within the Antennal Lobe of Drosophila melanogaster

Sizemore

Dacks

2016

Sci Rep

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“…Two-photon microscopy revealed that the aversive DM5 glomerulus, which is required for aversion to high concentrations of vinegar (Semmelhack and Wang 2009), became reduced in sensitivity and required higher concentrations of vinegar to become active in starved flies than in fed flies. This modulation co-occurred with the effect of starvation-induced increases of short neuropeptide F (sNPF) signaling in the innately attractive DM1 glomerulus (Ko et al 2015; Root et al 2011). This suggests a dual mechanism for starvation-dependent reduction in aversion.…”

Section: Effects Of Internal State On Aversionmentioning

confidence: 92%

“…Another example of starvation increasing tolerance for aversive odors is the role of tachykinin (DTK) in suppressing the activity of the DM5 glomerulus in D. melanogaster (Ko et al 2015). Knocking down DTK reduced attraction to medium concentrations of apple cider vinegar in starved flies, but not fed flies.…”

Section: Effects Of Internal State On Aversionmentioning

confidence: 99%

Olfactory Mechanisms for Discovery of Odorants to Reduce Insect-Host Contact

Clark

Ray

2016

J Chem Ecol

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Insects have developed highly sophisticated and sensitive olfactory systems to find animal or plant hosts for feeding. Some insects vector pathogens that cause diseases in hundreds of millions of people and destroy billions of dollars of food products every year. There is great interest, therefore, in understanding how the insect olfactory system can be manipulated to reduce their contact with hosts. Here, we review recent advances in our understanding of insect olfactory detection mechanisms, which may serve as a foundation for designing insect control programs based on manipulation of their behaviors by using odorants. Because every insect species has a unique set of olfactory receptors and olfactory-mediated behaviors, we focus primarily on general principles of odor detection that potentially apply to most insects. While these mechanisms have emerged from studies on model systems for study of insect olfaction, such as Drosophila melanogaster, they provide a foundation for discovery of odorants to repel insects or reduce host-seeking behavior.

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“…Previous reports showed that endocrine secretions can tune chemosensory system in Drosophila (Ko et al, 2015;Root et al, 2011). However, these responses could differ strongly in social insects.…”

Section: Introductionmentioning

confidence: 98%

Insulin effects on honeybee appetitive behaviour

Goñalons

Guiraud

Sanchez

et al. 2016

Journal of Experimental Biology

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Worker honeybees (Apis mellifera) carry out multiple tasks throughout their adult lifespan. It has been suggested that the insulin/insulin-like signalling pathway participates in regulating behavioural maturation in eusocial insects. Insulin signalling increases as the honeybee worker transitions from nurse to food processor to forager. As behavioural shifts require differential usage of sensory modalities, our aim was to assess insulin effects on olfactory and gustatory responsiveness as well as on olfactory learning in preforaging honeybee workers of different ages. Adults were reared in the laboratory or in the hive. Immediately after being injected with insulin or vehicle (control), and focusing on the proboscis extension response, bees were tested for their spontaneous response to odours, sucrose responsiveness and ability to discriminate odours through olfactory conditioning. Bees injected with insulin have higher spontaneous odour responses. Sucrose responsiveness and odour discrimination are differentially affected by treatment according to age: whereas insulin increases gustatory responsiveness and diminishes learning abilities of younger workers, it has the opposite effect on older bees. In summary, insulin can improve chemosensory responsiveness in young workers, but also worsens their learning abilities to discriminate odours. The insulin signalling pathway is responsive in young workers, although they are not yet initiating outdoor activities. Our results show strong age-dependent effects of insulin on appetitive behaviour, which uncover differences in insulin signalling regulation throughout the honeybee worker's adulthood.

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Starvation promotes concerted modulation of appetitive olfactory behavior via parallel neuromodulatory circuits

Cited by 166 publications

References 64 publications

Serotonergic Modulation Differentially Targets Distinct Network Elements within the Antennal Lobe of Drosophila melanogaster

Serotonergic Modulation Differentially Targets Distinct Network Elements within the Antennal Lobe of Drosophila melanogaster

Olfactory Mechanisms for Discovery of Odorants to Reduce Insect-Host Contact

Insulin effects on honeybee appetitive behaviour

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