Starvation and Refeeding in Rats: Effect on Organismic Respiration, Cytoplasmic Constituents of Liver, and Succinic Dehydrogenase Activity in Liver, Kidney, and Heart

Cascarano, Joseph; Migler, Regina; Wilson, Margaret A.

doi:10.1093/jn/108.10.1606

Cited by 16 publications

(4 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…RIBF,,,,,. and MBF,,,, were also similar for groups A, B and D, but differed for rats in groups C and E. _____ return in resting metabolic rates to the exact prestarvation value for both humans (Grande et al 1958) and rats (Cascarano et at. 1978).…”

Section: I S C U S S I O~mentioning

confidence: 86%

Resting oxygen consumption in rats during food restriction, starvation and refeeding

Munch

Markussen

Øritsland

1993

Acta Physiologica Scandinavica

View full text Add to dashboard Cite

Oxygen consumption was measured in male rats during starvation and during different regimens of restricted feeding and refeeding after starvation. Changes in oxygen consumption and body mass were mostly parallel, but rats with a very reduced food intake displayed the same reduction in oxygen consumption as starved rats, despite the smaller reduction in body mass. Also, rats fed different amounts of food after starvation had different oxygen consumptions, but displayed the same changes in body mass. Two different refeeding regimens with restricted food amounts either induced a further depression of oxygen consumption (i.e. below starvation oxygen consumption), or a stabilizing of oxygen consumption on the level of starvation. The changes in oxygen consumption during restriction and feeding after starvation indicate that reductions in resting metabolic rate may not always be predicted from either body mass change or food intake.

show abstract

Section: I S C U S S I O~mentioning

confidence: 86%

Resting oxygen consumption in rats during food restriction, starvation and refeeding

Munch

Markussen

Øritsland

1993

Acta Physiologica Scandinavica

View full text Add to dashboard Cite

show abstract

“…Whereas no significant differences in the relative fat content were found among the three groups, expectedly, RES rat livers contained significantly less glycogen than AL livers [ 11 ]. Earlier observations in older rats have shown that the livers generally maintained similar amounts of cells in RES, AL and CU [ 42 ], implying that the size of RES liver cells was half of the AL cells with minimal levels of glycogen [ 11 ]. Yet, we also found that the RES cells accumulated 7 % of new proteins mostly in the mitochondria, to drive the catabolism of carbohydrates, lipids and proteins.…”

Section: Discussionmentioning

confidence: 99%

Quantitative proteomics of rat livers shows that unrestricted feeding is stressful for proteostasis with implications on life span

Gat-Yablonski

Finka

Pinto

et al. 2016

Aging

View full text Add to dashboard Cite

Studies in young mammals on the molecular effects of food restriction leading to prolong adult life are scares. Here, we used high-throughput quantitative proteomic analysis of whole rat livers to address the molecular basis for growth arrest and the apparent life-prolonging phenotype of the food restriction regimen. Over 1800 common proteins were significantly quantified in livers of ad libitum, restriction- and re-fed rats, which summed up into 92% of the total protein mass of the cells. Compared to restriction, ad libitum cells contained significantly less mitochondrial catabolic enzymes and more cytosolic and ER HSP90 and HSP70 chaperones, which are hallmarks of heat- and chemically-stressed tissues. Following re-feeding, levels of HSPs nearly reached ad libitum levels. The quantitative and qualitative protein values indicated that the restriction regimen was a least stressful condition that used minimal amounts of HSP-chaperones to maintain optimal protein homeostasis and sustain optimal life span. In contrast, the elevated levels of HSP-chaperones in ad libitum tissues were characteristic of a chronic stress, which in the long term could lead to early aging and shorter life span.

show abstract

“…The mitochondria play an important role in fatty acid oxidation and changes might be expected in fasting where increased myocardial utilisation of fatty acids occurs. Cascarano et al (1978) studied the effects of fasting of rats for up to 6 days on certain mitochondria1 enzymes. Whereas succinic dehydrogenase activity in liver and kidney fell steadily, that in the heart doubled at 2 days and fell to normal values by 4 days.…”

Section: Correlation With Biochemical Changesmentioning

confidence: 99%

Fat accumulation in the rat heart during fasting

Adams

Barer

Joseph

et al. 1981

The Journal of Pathology

View full text Add to dashboard Cite

Following a short period of fasting, with free access to water, lipid droplet accumulation (LDA) occurs in many glandular organs as well as in the heart of several species. The present work describes the changes in the hearts of male and female rats of different ages (6, 12, 18 and 24 weeks) deprived of food for 1, 2 and 3 days. LDA was demonstrated by staining with Oil Red O and a special "scoring" system was developed based on sections arbitrarily divided into five regions for each ventricle and two for each atrium. Three standard sections were studied from each heart. This system largely avoided problems arising from the uneven distribution of fats in different parts of the heart. In control animals very little fat was seen in any part of the heart. The pattern of changes was similar in males and females but the degree of LDA was usually much greater in the male. In both sexes LDA increased after 1 day and usually reached a peak by the second day, followed by a sharp decrease, returning to almost normal. However in both sexes the response in the 18-week-old animals was minimal, with no clear peak. The LDA was always maximal in the R ventricle, followed by the L ventricle. The heaviest deposition occurred in the superior parts of the ventricles, close to the atria. LDA was comparatively rare in the atria. Fat appeared to be retained longest in the most heavily loaded regions. Recovery from LDA was rapid, being almost complete 24 hr after returning to a normal diet. Again the most heavily loaded regions retained fat longest. These findings are discussed in related to possible anatomical factors such as the distribution of blood vessels. It is unlikely that such factors offer an adequate explanation abd it is suggested that since the uptake of fats into the heart is probably controlled by lipoprotein lipase the distribution of this enzyme in difference parts of the heart should be investigated. The histochemical changes are also discussed in relation to previous biochemical work. Finally it is pointed out that it is common procedure to fast experimental animals overnight and even such a brief period could bring about considerable histological and metabolic changes.

show abstract

Starvation and Refeeding in Rats: Effect on Organismic Respiration, Cytoplasmic Constituents of Liver, and Succinic Dehydrogenase Activity in Liver, Kidney, and Heart

Cited by 16 publications

References 41 publications

Resting oxygen consumption in rats during food restriction, starvation and refeeding

Resting oxygen consumption in rats during food restriction, starvation and refeeding

Quantitative proteomics of rat livers shows that unrestricted feeding is stressful for proteostasis with implications on life span

Fat accumulation in the rat heart during fasting

Contact Info

Product

Resources

About