Starvation and Age Effects on Glycoregulation and Hormone Levels of C57BL/6J ob/ob Mice

Dubuc, Paul U.; Cahn, P J; S, Ristimaki; Willis, Patricia

doi:10.1055/s-2007-1019069

Cited by 15 publications

(12 citation statements)

References 18 publications

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“…The hyperglycemia associated with the ob/ob mutation becomes progressively less severe after about 3 months of age and glycemia approaches that of lean mice 2 to 3 months later (15,16). Although glucose values from lean mice were not included in the present study, a d libitum-fed glycemia in untreated ob/ob mice was within the range generally seen in 5to 6-month-old lean mice (Table 11).…”

Section: Food Intake No Gender Differences In Dailysupporting

confidence: 53%

Effects of Estrogen on Food Intake, Body Weight, and Temperature of Male and Female Obese Mice

Dubuc

1985

Experimental Biology and Medicine

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Estradiol benzoate (EB) treatment of male and female C57BL/6J oblob mice for 32 days led to decreased body weight (20%), percentage body fat (8%) and carcass protein content (12%) when compared with non-EB-treated obese control mice. Estradiol reduced the caloric intakes of both genders by 25-35% but did not affect body temperature regulation. Circulating glucose and insulin concentrations were also lowered by estrogens, although hyperinsulinemia persisted. Since post-treatment body weight changes correlated with daily food intakes (r = 0.8 1 ) rather than to rectal temperatures (r = -0.19), it appears that hypophagia provided a greater contribution to the estrogen-mediated reductions of growth and carcass fat than did altered energy expenditure for thermoregulation. While these data show that EB treatment does reduce the severity of some metabolic disturbances in a genetic model of type I1 diabetes, long-term estrogens do not appear to offer substantial advantages in the treatment of obesity or diabetes when compared with the effects of caloric restriction alone.

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Section: Food Intake No Gender Differences In Dailysupporting

confidence: 53%

Effects of Estrogen on Food Intake, Body Weight, and Temperature of Male and Female Obese Mice

Dubuc

1985

Experimental Biology and Medicine

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“…2). However, plasma levels of glucose after 6 months were lower in naive obese mice, indicating an amelioration of the diabetic state, as described previously (Dubuc et al, 1982;Lindström, 2007). In contrast, plasma levels of glucose after 6 months were increased in the naive lean mice compared with the initial levels ( Fig.…”

Section: Resultsmentioning

confidence: 51%

Chronic Ethanol Consumption Lessens the Gain of Body Weight, Liver Triglycerides, and Diabetes in Obese ob/ob Mice

Fromenty

Vadrot²,

Massart³

et al. 2009

J Pharmacol Exp Ther

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Clinical studies suggest that moderate alcohol consumption can have beneficial effects, in particular regarding cardiovascular events, insulin resistance, and type 2 diabetes. In this study, lean and obese diabetic ob/ob mice were submitted or not to chronic ethanol intake via the drinking water for 6 months, which was associated with moderate levels of plasma ethanol. Plasma levels of alanine aminotransferase and aspartate aminotransferase were not increased by alcohol intake. Ethanol consumption progressively reduced the gain of body weight in ob/ob mice, but not in lean mice, and this was observed despite higher calorie intake. Increased plasma free fatty acids and glycerol in ethanol-treated ob/ob mice suggested peripheral lipolysis. Glycemia and insulinemia were significantly reduced, whereas adiponectinemia was increased in ethanol-treated ob/ob mice. Liver weight and triglycerides were significantly decreased in ethanol-treated ob/ob mice, and this was associated with less microvesicular steatosis. Hepatic levels of AMP-activated protein kinase and the phosphorylated form of acetyl-CoA carboxylase were higher in ethanol-treated ob/ob mice, suggesting better fatty acid oxidation. However, hepatic mRNA expression of several lipogenic genes was not reduced by ethanol consumption. Finally, mild oxidative stress was noticed in the liver of ethanol-treated mice, regardless of their genotype. Hence, our data are in keeping with clinical studies suggesting that moderate ethanol intake can have beneficial effects on type 2 diabetes and insulin sensitivity, at least in part through increased levels of plasma adiponectin. However, further studies are needed to determine whether longterm drinking of light-to-moderate amounts of ethanol is safe for the liver.

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“…Although leptin functioning in the FATZO mouse has not been investigated thoroughly, some observations suggest that the pathway is intact. Firstly, leptin pathway interruption typically results in prominent hyperphagia [37,48–51] which has not been observed in FATZO mice fed normal chow (unpublished data). However, an increase in caloric intake in heavier animals when fed the high fat diet may indicate leptin resistance.…”

Section: Discussionmentioning

confidence: 99%

“…Since single-gene leptin pathway defects are very rare in the human population [52–56], animals with these defects are not representative of the clinical landscape. The ob / ob model on the C57BL/6J background, lacks active leptin [48,50,57,58]. It has large islets which respond by releasing insulin with glucose elevations.…”

Section: Discussionmentioning

confidence: 99%

Correlation of disease severity with body weight and high fat diet in the FATZO/Pco mouse

Droz¹,

Sneed²,

Jackson³

et al. 2017

PLoS ONE

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Obesity in many current pre-clinical animal models of obesity and diabetes is mediated by monogenic mutations; these are rarely associated with the development of human obesity. A new mouse model, the FATZO mouse, has been developed to provide polygenic obesity and a metabolic pattern of hyperglycemia and hyperinsulinemia, that support the presence of insulin resistance similar to metabolic disease in patients with insulin resistance/type 2 diabetes. The FATZO mouse resulted from a cross of C57BL/6J and AKR/J mice followed by selective inbreeding for obesity, increased insulin and hyperglycemia. Since many clinical studies have established a close link between higher body weight and the development of type 2 diabetes, we investigated whether time to progression to type 2 diabetes or disease severity in FATZO mice was dependent on weight gain in young animals. Our results indicate that lighter animals developed metabolic disturbances much slower and to a lesser magnitude than their heavier counterparts. Consumption of a diet containing high fat, accelerated weight gain in parallel with disease progression. A naturally occurring and significant variation in the body weight of FATZO offspring enables these mice to be identified as low, mid and high body weight groups at a young age. These weight groups remain into adulthood and correspond to slow, medium and accelerated development of type 2 diabetes. Thus, body weight inclusion criteria can optimize the FATZO model for studies of prevention, stabilization or treatment of type 2 diabetes.

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Starvation and Age Effects on Glycoregulation and Hormone Levels of C57BL/6J ob/ob Mice

Cited by 15 publications

References 18 publications

Effects of Estrogen on Food Intake, Body Weight, and Temperature of Male and Female Obese Mice

Effects of Estrogen on Food Intake, Body Weight, and Temperature of Male and Female Obese Mice

Chronic Ethanol Consumption Lessens the Gain of Body Weight, Liver Triglycerides, and Diabetes in Obese ob/ob Mice

Correlation of disease severity with body weight and high fat diet in the FATZO/Pco mouse

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