Starter formula enriched in prebiotics and probiotics ensures normal growth of infants and promotes gut health: a randomized clinical trial

Abstract

Articles Clinical Investigation nature publishing groupBackground: Prebiotics and probiotics exert beneficial effects by modulating gut microbiota and immune system. This study evaluates efficacy and safety of an infant formula containing bovine milk-derived oligosaccharides and Bifidobacterium animalis ssp lactis (B. lactis) (CNCM I-3446) on incidence of diarrhea and febrile infections during the first year of life (primary outcome). Methods: Full-term infants receiving Test or Control (without bovine milk-derived oligosaccharide and B. lactis) formulae were enrolled in a multicenter, randomized, controlled, and double-blind trial with a reference breastfeeding group. . results: 413 infants were assigned between Test (n = 206) and Control (n = 207) formula. There was no significant difference for diarrhea and febrile infections incidence between groups at 6 (odds ratio (95% confidence interval) = 0.56 (0.26-1.15), P = 0.096) and 12 mo (odds ratio = 0.66 (0.38-1.14), P = 0.119). Test formula was well tolerated, anthropometrics parameters were not significantly different between groups and aligned with WHO growth standards up to 12 mo. Data from test group showed that gut microbiota pattern, fecal IgA and stool pH were brought to be closer to those of breastfed infants. conclusion: An infant formula enriched with bovine milkderived oligosaccharide and B. lactis supports normal infant growth, is well tolerated and improves intestinal health markers. No differences in diarrhea and febrile infection incidence were found in the population studied.

Synbiotic Effect of Bifidobacterium lactis CNCM I-3446 and Bovine Milk-Derived Oligosaccharides on Infant Gut Microbiota

“…However, E. coli was suppressed in the presence of synbiotics (BMOS and B. lactis). Similar findings were reported in clinical studies using infant formulas enriched in BMOS and B. lactis [35,36,83].…”

“…The synbiotic formulations significantly increased the early lactate and acetate production, observed within the first 6 h of incubation. The effect of B. lactis with BMOS on microbiota activity has also been reported in clinical trials in infants [35,36,83]. The synergy between BMOS and B. lactis CNCM I-3446 is likely explained by the fact that this strain was specifically selected for its ability to readily ferment BMOS (unpublished data).…”

Human and Bovine Milk Oligosaccharides Elicit Improved Recognition Memory Concurrent With Alterations in Regional Brain Volumes and Hippocampal mRNA Expression

“…Infants fed formula supplemented with BMOS have shown tolerance and adequate growth as measured by anthropomorphic measures (e.g., weight-for-age, lengthfor-age, or head-circumference scores) and stool characteristic (e.g., frequency, consistency, or pH) closer to that of breastfed infants (Meli et al, 2014;Cooper et al, 2016;Simeoni et al, 2016;Radke et al, 2017). Provision of a combination of BMOS and Bifidobacterium animalis subsp.…”

Healthy chocolate enriched with probiotics: a review

“…In particular, bovine milk-derived oligosaccharides support the growth of probiotic B. animalis ssp. lactis and improves intestinal health (Radke et al, 2017). Chen et al (2013) evaluated the prebiotic properties of pectic oligosaccharides (POS) using a fecal batch culture fermentation.…”