STARD5 as a potential clinical target of hepatocellular carcinoma

Liu, Qi; Du, Xiaoxiao; Yu, Zepeng; Yao, Qingbin; Meng, Xiaoxiang; Zhang, Kun; Zheng, Lemin; Wang, Hong

doi:10.1007/s12032-022-01750-8

Cited by 4 publications

(4 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…STARD5 is key for cholesterol homeostasis regulation, especially in liver cells [ 54 ]. It is indeed hepatocellular carcinoma where it has been recently proposed as a potential diagnostic and prognostic biomarker, with high expression associated with lower tumor grade and better prognosis [ 55 ], indirectly in contrast with our results in BC. In our study, it was also correlated with three miRNA: positively with hsa‐miR‐29c‐3p and negatively with hsa‐miR‐937‐5p and hsa‐miR‐1249.…”

Section: Discussioncontrasting

confidence: 79%

Integrative analysis of mRNA and miRNA expression profiles and somatic variants in oxysterol signaling in early‐stage luminal breast cancer

et al. 2023

View full text Add to dashboard Cite

Oxysterols, oxidized derivatives of cholesterol, act in breast cancer (BC) as selective estrogen‐receptor modulators and affect cholesterol homeostasis, drug transport, nuclear and cell receptors, and other signaling proteins. Using data from three highly overlapping sets of patients (N=162 in total) with early‐stage estrogen‐receptor‐positive luminal BC—high‐coverage targeted DNA sequencing (113 genes), mRNA sequencing, and full micro‐RNA (miRNA) transcriptome microarrays—we describe complex oxysterol‐related interaction (correlation) networks, with validation in public datasets (n=538) and 11 databases. The ESR1‐CH25H‐INSIG1‐ABCA9 axis was the most prominent, interconnected through miR‐125b‐5p, miR‐99a‐5p, miR‐100‐5p, miR‐143‐3p, miR‐199b‐5p, miR‐376a‐3p and miR‐376c‐3p. Mutations in SC5D, CYP46A1, and its functionally linked gene set were associated with multiple differentially expressed oxysterol‐related genes. STARD5 was upregulated in patients with positive lymph‐node status. High expression of hsa‐miR‐19b‐3p was weakly associated with poor survival. This is the first study of oxysterol‐related genes in BC that combines DNA, mRNA and miRNA multi‐omics with detailed clinical data. Future studies should provide links between intra‐tumoral oxysterol signaling depicted here, circulating oxysterols levels, and therapy outcomes, enabling eventual clinical exploitation of present findings.

show abstract

Section: Discussioncontrasting

confidence: 79%

Integrative analysis of mRNA and miRNA expression profiles and somatic variants in oxysterol signaling in early‐stage luminal breast cancer

et al. 2023

View full text Add to dashboard Cite

show abstract

“…4 A). StarD5 plays a crucial role in maintaining hepatic cholesterol homeostasis, and its perturbation has been shown to contribute to apoptotic and hepatocellular carcinogenesis ( 90 , 91 ). This alteration implies an augmented activation of the ER-stress response, leading to subsequent perturbations in liver cholesterol and cholesterol ester content, along with a simultaneous increase in intracellular neutral lipids, such as di- and mono-acylglycerols, as observed here (Fig.…”

Section: Resultsmentioning

confidence: 99%

Schistosoma mansoni infection induces hepatic metallothionein and S100 protein expression alongside metabolic dysfunction in hamsters

Ghezellou,

von Bülow,

Luh

et al. 2024

PNAS Nexus

View full text Add to dashboard Cite

Schistosomiasis, a widespread neglected tropical disease, presents a complex and multifaceted clinical-pathological profile. Using hamsters as final hosts, we dissected molecular events following Schistosoma mansoni infection in the liver - the organ most severely affected in schistosomiasis patients. Employing TMT-based proteomics, we studied alterations in the liver proteins in response to various infection modes and genders. We examined livers from female and male hamsters that were: non-infected (control), infected with either unisexual S. mansoni cercariae (single-sex), or both sexes (bisex). The infection induced upregulation of proteins associated with immune response, cytoskeletal reorganization, and apoptotic signaling. Notably, S. mansoni egg deposition led to the downregulation of liver factors linked to energy supply and metabolic processes. Gender-specific responses were observed, with males showing higher susceptibility, supported by more differentially expressed proteins than females. Of note, Metallothionein-2 and S100a6 proteins exhibited substantial upregulation in livers of both genders, suggesting their pivotal roles in the liver's injury response. Immunohistochemistry and RT-qPCR confirmed strong upregulation of Metallothionein-2 expression in the cytoplasm and nucleus upon the infection. Similar findings were seen for S100a6, which localized around granulomas and portal tracts. We also observed perturbations in metabolic pathways, including downregulation of enzymes involved in xenobiotic biotransformation, cellular energy metabolism and lipid modulation. Furthermore, lipidomic analyses through LC-MS/MS and MALDI-MSI identified extensive alterations, notably in cardiolipin and triacylglycerols, suggesting specific roles of lipids during pathogenesis. These findings provide unprecedented insights into the hepatic response to S. mansoni infection, shedding light on the complexity of liver pathology in this disease.

show abstract

“…Abnormal cholesterol metabolism is directly correlated with tumor occurrence and growth. It has been established that STARD5 is a valuable biomarker for assessing hepatocellular carcinoma (HCC) prognosis, and high expression of STARD5 implies a better prognosis ( 89 ).…”

Section: Discussionmentioning

confidence: 99%

Progressions of the correlation between lipid metabolism and immune infiltration characteristics in gastric cancer and identification of BCHE as a potential biomarker

Wang,

Huang,

Zhao

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

BackgroundGlobally, gastric cancer (GC) is a category of prevalent malignant tumors. Its high occurrence and fatality rates represent a severe threat to public health. According to recent research, lipid metabolism (LM) reprogramming impacts immune cells’ ordinary function and is critical for the onset and development of cancer. Consequently, the article conducted a sophisticated bioinformatics analysis to explore the potential connection between LM and GC.MethodsWe first undertook a differential analysis of the TCGA queue to recognize lipid metabolism-related genes (LRGs) that are differentially expressed. Subsequently, we utilized the LASSO and Cox regression analyses to create a predictive signature and validated it with the GSE15459 cohort. Furthermore, we examined somatic mutations, immune checkpoints, tumor immune dysfunction and exclusion (TIDE), and drug sensitivity analyses to forecast the signature’s immunotherapy responses.ResultsKaplan-Meier (K-M) curves exhibited considerably longer OS and PFS (p<0.001) of the low-risk (LR) group. PCA analysis and ROC curves evaluated the model’s predictive efficacy. Additionally, GSEA analysis demonstrated that a multitude of carcinogenic and matrix-related pathways were much in the high-risk (HR) group. We then developed a nomogram to enhance its clinical practicality, and we quantitatively analyzed tumor-infiltrating immune cells (TIICs) using the CIBERSORT and ssGSEA algorithms. The low-risk group has a lower likelihood of immune escape and more effective in chemotherapy and immunotherapy. Eventually, we selected BCHE as a potential biomarker for further research and validated its expression. Next, we conducted a series of cell experiments (including CCK-8 assay, Colony formation assay, wound healing assay and Transwell assays) to prove the impact of BCHE on gastric cancer biological behavior.DiscussionOur research illustrated the possible consequences of lipid metabolism in GC, and we identified BCHE as a potential therapeutic target for GC. The LRG-based signature could independently forecast the outcome of GC patients and guide personalized therapy.

show abstract

STARD5 as a potential clinical target of hepatocellular carcinoma

Cited by 4 publications

References 44 publications

Integrative analysis of mRNA and miRNA expression profiles and somatic variants in oxysterol signaling in early‐stage luminal breast cancer

Integrative analysis of mRNA and miRNA expression profiles and somatic variants in oxysterol signaling in early‐stage luminal breast cancer

Schistosoma mansoni infection induces hepatic metallothionein and S100 protein expression alongside metabolic dysfunction in hamsters

Progressions of the correlation between lipid metabolism and immune infiltration characteristics in gastric cancer and identification of BCHE as a potential biomarker

Contact Info

Product

Resources

About