Starch nanofibers as vehicles for folic acid supplementation: thermal treatment, <scp>UVA</scp> irradiation and <i>in vitro</i> simulation of digestion

Fonseca, Laura Martins; Crizel, Rosane Lopes; Silva, Francine Tavares da; Fontes, Milena Ramos Vaz; Zavareze, Elessandra da Rosa

doi:10.1002/jsfa.10809

Cited by 14 publications

(11 citation statements)

References 29 publications

(56 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, folic acid has received much attention from researchers in the fields of biomedical, bioengineering, and regenerative therapies, because of its non-immunogenicity, high stability, and ability to support tissue regeneration/repair [ 26 , 27 ]. In this regard, an increasing number of studies on the use of folic acid in micro/nanocapsule, liposome, hydrogel and/or nanofiber forms are available in a wide range of applications [ 28 , 29 , 30 ]. However, there are no studies in the literature on the utilization of nanofibers containing FA in tissue engineering applications, formed by both blending electrospinning and simultaneous (electrospinning and electrospraying) processes.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Electrospun Folic Acid/Hybrid Fibers: In Vitro Controlled Release Study and Cytocompatibility Assays

et al. 2021

View full text Add to dashboard Cite

The fabrication of skin-care products with therapeutic properties has been significant for human health trends. In this study, we developed efficient hydrophilic composite nanofibers (NFs) loaded with the folic acid (FA) by electrospinning and electrospraying processes for tissue engineering or wound healing cosmetic applications. The morphological, chemical and thermal characteristics, in vitro release properties, and cytocompatibility of the resulting composite fibers with the same amount of folic acid were analyzed. The SEM micrographs indicate that the obtained nanofibers were in the nanometer range, with an average fiber diameter of 75–270 nm and a good porosity ratio (34–55%). The TGA curves show that FA inhibits the degradation of the polymer and acts as an antioxidant at high temperatures. More physical interaction between FA and matrices has been shown to occur in the electrospray process than in the electrospinning process. A UV-Vis in vitro study of FA-loaded electrospun fibers for 8 h in artificial acidic (pH 5.44) and alkaline (pH 8.04) sweat solutions exhibited a rapid release of FA-loaded electrospun fibers, showing the effect of polymer matrix–FA interactions and fabrication processes on their release from the nanofibers. PVA-CHi/FA webs have the highest release value, with 95.2% in alkaline media. In acidic media, the highest release (92%) occurred on the PVA-Gel–CHi/sFA sample, and this followed first-order and Korsmeyer–Peppas kinetic models. Further, the L929 cytocompatibility assay results pointed out that all NFs (with/without FA) generated had no cell toxicity; on the contrary, the FA in the fibers facilitates cell growth. Therefore, the nanofibers are a potential candidate material in skin-care and tissue engineering applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Electrospun Folic Acid/Hybrid Fibers: In Vitro Controlled Release Study and Cytocompatibility Assays

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The release behavior of nanofibers containing various amounts of FA (5, 10, and 15 %) were obtained using starch as a matrix. Although the diameters of nanofibers produced below 100 nm did not vary much, some beads in FAloaded fibers was detected [13].…”

Section: Introductionmentioning

confidence: 88%

Development and Characterization of Vitamin B9 - Electrosprayed Non-Woven Surfaces for Wound Healing Applications

Parın¹,

Yildirim²,

Taner³

et al. 2021

Eskişehir Technical University Journal of Science and Technology a - Applied Sciences and Engineering

View full text Add to dashboard Cite

In this study, novel wound dressing materials based on non-woven (NW) surfaces were developed using the electrospraying (e-spraying) process. Polyester spun-bond (PET SPB), polypropylene spun-bond (PP SPB), and polypropylene melt-blown (PP MB) surfaces used as matrix, and folic acid (FA), vitamin B9weresprayed on these surfaces. The resulting NW fabrics with the same FA content were investigated in terms of physical, morphological, thermal, wettability properties.Scanning Electron Microscopy and (SEM) and Fourier Transform Infrared (FT-IR) spectroscopy results showed the formation of physical interaction between NWs and FA.Notably, FA was successfully deposited onto NWs with average fiber diameters from 2.6 µm to 23.11 µm. According to the thermogravimetric analysis (TGA),FA loaded-PP SPB has enhanced thermal stability compared to pure one (PP SPB). The FA-loaded surfaces have a hydrophobic property with contact angles values more than >90°. The in-vitro release was carried out by UV-Vis within the 8 hour-period phosphate buffer saline (pH 7.2). The results indicated that FA-loaded surfaces have a fast release behaviour. The total FA release amounts of the FA-loaded PET SBP, PP SPB and PP MB NWs were found as 22.8, 17.1, and 17.5 ppm. Moreover, the biocompatibility of all resulting NW surfaces was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and neutral red uptake (NRU) cytotoxicity tests in L929 cell lines.The obtained NWs are biocompatible and non-toxic material, except PET SPB-sFA.The study indicated that FA-loaded NWs can be potential candidates for wound healing applications.

show abstract

“…Therefore, starch is usually mixed with other polymers for electrospinning 79 . The application of starch electrospun fiber in food engineering is concentrated in food packaging [80][81][82][83][84][85][86][87] , such as bread packaging 88 , bean product packaging 89 ; Starch has also been researched in functional food 90,91 .…”

Section: Soluble Starchmentioning

confidence: 99%

Green electrospinning for safe food engineering

Jiang

Che³

et al. 2023

Preprint

View full text Add to dashboard Cite

The nanofibers formed by electrospinning technology have the advantages of orderly release mechanism and controllable dissolution rate. However, the use of toxic and harmful organic solvents is widespread in the field of electrospinning, which not only poses a potential hazard to human health and the natural environment, but also increases the manufacturing cost and difficulty of electrospinning. Therefore, the purpose of this paper is to introduce the application of green electrospinning technology in food engineering. Water solvent electrospinning is mainly introduced, and some water-soluble biopolymer and synthetic polymers are reviewed. Their latest applications and development limitations in the field of food engineering are introduced and discussed. The water solvent electrospinning introduced here transforms a process that has adverse effects on the environment and health into a scalable and ecologically conscious “green” electrospinning, which is both important and timely and will bring exemplary changes to the field of food engineering.

show abstract

Starch nanofibers as vehicles for folic acid supplementation: thermal treatment, UVA irradiation and in vitro simulation of digestion

Cited by 14 publications

References 29 publications

Fabrication and Characterization of Electrospun Folic Acid/Hybrid Fibers: In Vitro Controlled Release Study and Cytocompatibility Assays

Fabrication and Characterization of Electrospun Folic Acid/Hybrid Fibers: In Vitro Controlled Release Study and Cytocompatibility Assays

Development and Characterization of Vitamin B9 - Electrosprayed Non-Woven Surfaces for Wound Healing Applications

Green electrospinning for safe food engineering

Contact Info

Product

Resources

About