Starch microsponges for enhanced retention and efficacy of topical sunscreen

Bhuptani, Ronak S.; Patravale, Vandana

doi:10.1016/j.msec.2019.109882

Cited by 17 publications

(3 citation statements)

References 38 publications

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“…The optimized formulation was prepared, characterized and clinically tested. Starch microsponges-based sunscreen product possessed good spreading properties, non-sticky, rich texture, and good patient compliance [82]. In vitro and Ex-vivo studies showed that starch microsponges offer higher SPF, enhanced photoprotection, and lowered the cutaneous penetration contrasted with commercial cream (as shown in Figure 3).…”

Section: 62starch Microsponges-based Topical Sunscreen Productmentioning

confidence: 98%

Therapeutic Application of Microsponges-based Drug Delivery Systems

Rahman

Almalki

Panda³

et al. 2022

CPD

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Microsponges delivery system (MDS) is highly porous, cross-linked based polymeric systems, that activates in the presence of temperature, rubbing and pH. MDS offers wide range of advantage, like controlled drug release, site-specific action, stable over a broad range of pH, poor irritation, cost effective, improved patient compliance. They can be transformed into various dosage forms like creams, gels, and lotions. MDS based system are suitable for treatment of topical disorders like acne, psoriasis, dandruff, eczema, scleroderma, hair loss, skin cancer, and other dreadful diseases. MDS application for drug delivery is not limited to topical drug delivery but also explored for oral, parenteral and pulmonary drug delivery. Microsponges were studied for colon targeting of drugs and genes. Additionally, MDS has wide application for sunscreen, cosmetics, and over the counter (OTC) products. Furthermore, MDS does not actuate any irritation, genotoxicity, immunogenicity or cytotoxicity. Therefore, this review extensively highlights about microsponges, their advantages, key factors affecting the micro-sponges’ characteristics, the therapeutic application of microsponges in topical disorders, cancer, as cosmetics, recent advances in MDS and addresses the associated challenges.

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Section: 62starch Microsponges-based Topical Sunscreen Productmentioning

confidence: 98%

Therapeutic Application of Microsponges-based Drug Delivery Systems

Rahman

Almalki

Panda³

et al. 2022

CPD

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“…Microsponges are considered an advanced system for the delivery of a drug capable of encapsulating various agents like antiacne agents, essential oils, anti-inflammatory agents, and fragrances. , Their diameter ranges from 5 to 300 μm, and microcarriers are chosen as a medium for the topical delivery of medicines as they can prolong drug duration . Microsponges are efficient carriers capable of decreasing the unwanted local effects of dermatological agents.…”

Section: Nanocarriers For Topical Drug Deliverymentioning

confidence: 99%

New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

et al. 2023

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Skin, the largest organ in humans, is an efficient route for the delivery of drugs as it circumvents several disadvantages of the oral and parenteral routes. These advantages of skin have fascinated researchers in recent decades. Drug delivery via a topical route includes moving the drug from a topical product to a locally targeted region with dermal circulation throughout the body and deeper tissues. Still, due to the skin's barrier function, delivery through the skin can be difficult. Drug delivery to the skin using conventional formulations with micronized active components, for instance, lotions, gels, ointments, and creams, results in poor penetration. The use of nanoparticulate carriers is one of the promising strategies, as it provides efficient delivery of drugs through the skin and overcomes the disadvantage of traditional formulations. Nanoformulations with smaller particle sizes contribute to improved permeability of therapeutic agents, targeting, stability, and retention, making nanoformulations ideal for drug delivery through a topical route. Achieving sustained release and preserving a localized effect utilizing nanocarriers can result in the effective treatment of numerous infections or skin disorders. This article aims to evaluate and discuss the most recent developments of nanocarriers as therapeutic agent vehicles for skin conditions with patent technology and a market overview that will give future directions for research. As topical drug delivery systems have shown great preclinical results for skin problems, for future research directions, we anticipate including in-depth studies of nanocarrier behavior in various customized treatments to take into account the phenotypic variability of the disease.

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“…17,18 There have been many reports that different materials can be used as photoprotective agents to prevent human skin from UV lter damage. [19][20][21][22] Wu et al demonstrated that using polymethyl methacrylate (PMMA) to encapsulate organic UV lters improved their safety, photoprotectivity, and photostability. 19 Cabrera et al found that lipospheres are highly loaded and under a narrow particle distribution obtained from carnauba wax.…”

Section: Introductionmentioning

confidence: 99%