Starch-based nanocapsules fabricated through layer-by-layer assembly for oral delivery of protein to lower gastrointestinal tract

Zhang, Yiping; Chi, Chengdeng; Huang, Xiaoyi; Zou, Qin; Li, Xiaoxi; Ling, Chen

doi:10.1016/j.carbpol.2017.04.090

Cited by 77 publications

(49 citation statements)

References 33 publications

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“…By possible arrangement of the layer order, the nanocapsules formulated by LBL methods can achieve diverse drug release behavior in different pH environment. Therefore, LBL methods are beneficial to formulate nanocapsules as drug delivery system for oral administration to modulating the drug release in different part of digestive tract [121][122][123]. A pH-responsive multilayer prepared by LBL methods was developed which was composed of four polyelectrolytes: poly-L-arginine, sodium alginate, chitosan and Eudragit L100.…”

Section: Layer-by-layer Methodsmentioning

confidence: 99%

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

et al. 2020

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Polymer-based nanocapsules have been widely studied as a potential drug delivery system in recent years. Nanocapsules—as one of kind nanoparticle—provide a unique nanostructure, consisting of a liquid/solid core with a polymeric shell. This is of increasing interest in drug delivery applications. In this review, nanocapsules delivery systems studied in last decade are reviewed, along with nanocapsule formulation, characterizations of physical/chemical/biologic properties and applications. Furthermore, the challenges and opportunities of nanocapsules applications are also proposed.

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Section: Layer-by-layer Methodsmentioning

confidence: 99%

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

et al. 2020

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“…One common method involves the use of (3-chloro-2hydroxypropyl)trimethylammonium chloride (CHPTAC) ( Figure 4b) (Bayat Tork, Khalilzadeh, & Kouchakzadeh, 2017; Butrim, Bil'dyukevich, Butrim, & Yurkshtovich, 2016;Huang et al, 2019). Some other strategies that have been commonly applied to cellulose have also been applied to starch, to include carboxymethylation (Cai et al, 2019;Jiang et al, 2019;Li, Wu et al, 2019;Zhang, Pan et al, 2017;Zhang, Chi et al, 2017;Zhang, Tao, Niu, Li, & Chen, 2017), hydroxypropylation (Fang, Fu, Tao, Liu, & Cui (Li et al, 2020;Zhang, Ding, Gu, Tan, & Zhu, 2015;Zhao et al, 2015). Oxidation of C6 hydroxyl groups with catalytic TEMPO and bleach can be accomplished in a facile and environmentally friendly route in aqueous media (Figure 4d).…”

Section: Modification Strategiesmentioning

confidence: 99%

Recent advances in starch‐based films toward food packaging applications: Physicochemical, mechanical, and functional properties

Lauer

Smith

2020

Comp Rev Food Sci Food Safe

112

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Interest in starch-based films has increased precipitously in response to a growing demand for more sustainable and environmentally sourced food packaging materials. Starch is an optimal candidate for these applications given its ability to form thermoplastic materials and films with affordable and often sustainably sourced plasticizers like those produced as waste byproducts by biodiesel and agricultural industries. Starch is also globally ubiquitous, affordable, and environmentally benign. Although the process of producing starch films is relatively straightforward, numerous factors, including starch source, extraction method, film formulation, processing methods, and curing procedures, drastically impact the ultimate material properties. The significant strides made from 2015 to early 2020 toward elucidating how these variables can be leveraged to improve mechanical and barrier properties as well as the implementation of various additives or procedural modifications are cataloged in this review. Advances toward the development of functional films containing antioxidant, antibacterial, or spoilage indicating components to prevent or signal the degradation of food products are also discussed.

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“…In vitro digestibility was examined in accordance with the methods described by Zhang et al. [ 38 ] with some modifications. Samples (0.2 g) were immersed in the stomach, small intestine, and colon contents (10 mL) and sonicated for 1 min.…”

Section: Methodsmentioning

confidence: 99%

“…[ 34 ] Simulated gastric fluid (SGF, pH 1.2), simulated intestinal fluid (SIF, pH 6.8), and simulated colonic fluid (SCF, pH 7.2) were obtained in accordance with the method reported by Zhang et al. [ 38 ] Drug‐loaded samples (50 mg) were first dispersed in 5 mL of SGF, which was placed in the cellulose membrane. The suspension in the cellulose membrane was centrifuged at 15 000 × g for 5 min, the supernatant was collected and 5 mL of SIF was added to the residue and incubated again at 37 °C for another 6 h, then centrifuged.…”

Section: Methodsmentioning

confidence: 99%

Nanoresistant Particles Based on Chemically Modified Starch as Nanocarriers and Characterization of Structural and Release Properties

et al. 2020

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Nanoresistant particles based on chemically modified starch (RS IV) are prepared through a high‐speed shearing emulsification method, and the effects of shear speed, shear time, oil/water ratio, and surfactant amount on the particle size are evaluated in this study. The as‐prepared RS IV nanoparticles yield ≈300 nm narrow peak with notches and grooves on the surface. In vitro digestibility results suggest that these nanoparticles exhibit high resistance in the stomach, small intestine, and colon contents of mice. A raman assay confirms that a crosslinking reaction occurs between the RSIV molecule and N,N′‐methylenediacrylamide. X‐ray diffraction (XRD) and differential scanning calorimetry (DSC) reveal that RS IV nanoparticles present an amorphous structure. In addition, the RS IV nanoparticles have good thermal and storage stabilities. In comparison with RS IV, RS IV nanoparticles have a larger specific surface area, smaller average pore size, higher loading capacity and encapsulation efficiency, and better in vitro release properties of drugs.

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Starch-based nanocapsules fabricated through layer-by-layer assembly for oral delivery of protein to lower gastrointestinal tract

Cited by 77 publications

References 33 publications

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Recent advances in starch‐based films toward food packaging applications: Physicochemical, mechanical, and functional properties

Nanoresistant Particles Based on Chemically Modified Starch as Nanocarriers and Characterization of Structural and Release Properties

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