Star polymers composed entirely of amino acid building blocks: a route towards stereospecific, biodegradable and hierarchically functionalized stars

Sulistio, Adrian; Widjaya, Adrian; Blencowe, Anton; Zhang, Xiaoqing; Qiao, Greg G.

doi:10.1039/c0cc03541f

Cited by 70 publications

(80 citation statements)

References 25 publications

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“…A methyl or ethyl side chain was used to produce a hydrophilic monomer and a butyl side chain was used to produce a hydrophobic monomer. 235 For example, ring-opening polymerization of amino acid N-carboxyanhydrides has been effectively used to produce peptide star polymers with a PEG corona and a core containing cationic 236,237 or anionic 238 poly(amino acids). Using this strategy, one of the polymers ( polymer P2) was used to encapsulate the anticancer drug Paclixitel (PTX) (P2-PTX micelles).…”

Section: Peptides and Peptoidsmentioning

confidence: 99%

Antibiofouling polymer interfaces: poly(ethylene glycol) and other promising candidates

2015

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Nonspecific protein adsorption and/or microbial adsorption on biomedical materials adversely affects the efficacy of a range of biomedical systems, from implants and biosensors to nanoparticles. To address this problem, antibiofouling polymers can be coated on biomedical devices or built into nanoparticles to confer protein and/or microbial repellent properties. The current review provides an overview of the range of synthetic polymers currently used to this end and explores their biomedical potential. The most widely-used antifouling polymer, poly(ethylene glycol) (PEG) is reviewed alongside several promising alternatives, including zwitterionic polymers, poly(hydroxyfunctional acrylates), poly(2-oxazoline)s, poly (vinylpyrrolidone), poly(glycerol), peptides and peptoids. For each material, notable applications for both nanomedicine and macroscopic surface coatings are highlighted.

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Section: Peptides and Peptoidsmentioning

confidence: 99%

Antibiofouling polymer interfaces: poly(ethylene glycol) and other promising candidates

2015

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“…Bicarbonate (15 g, 15 mmol) was dissolved in 500 mL deionised (DI) water, l ‐cystine (4 g, 16.7 mmol) was then added . The mixture was enclosed in ice‐bath and cooled to 0 °C.…”

Section: Methodsmentioning

confidence: 99%

Imaging‐Guided pHe and Glutathione Dual Responsive Polypeptide Nanogel for Smart Drug Delivery

Jing

Ruan

et al. 2018

Macro Materials & Eng

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A negatively charged polypeptide nanogel, near‐infrared (NIR) cyanine dye (Cy5.5) conjugated and 2,3‐dimethylmaleic anhydride (DMA) modified poly‐l‐lysine‐co‐l‐cystine (CDPLC), is synthesized and is used as an imaging‐guided sequential drug delivery system. The CDPLC nanogel can respond to two general stimulations in sequence: extracellular tumor acidic microenvironment pHe (6.8–6.5) and intracellular high concentration glutathione (GSH). Under pHe, the DMA shell of the nanogel is removed and a charge reversal takes place, resulting in positively charged nanogel which can be internalized by cancer cells easily. Once internalized into tumor cells, the increased intracellular GSH concentration further promotes DOX release from the nanogel and DOX is enriched to the nucleus. Cy5.5 is conjugated to the nanogel as an NIR fluorescent probe, making it possible for imaging‐guided drug delivery, which is confirmed by the MTT and confocal laser scanning microscopy via in vitro experiments. The as‐prepared nanogel is a potential theranostic for cancer therapy.

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“…The core of the cross-linked star (CCS) polymers was degraded by cleavage of the disulfide bridge with DTT, yielding the star’s linear poly((e-Z-L-lysine)- b -(L-cysteine)) (P(ZLL- b -LC)) block copolymer components which were characterized by GPC. 227 …”

Section: Responsive Peptide-mediated Assemblymentioning

confidence: 99%

Responsive hybrid (poly)peptide–polymer conjugates

et al. 2017

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(Poly)peptide-polymer conjugates continue to garner significant interest in the production of functional materials given their composition of natural and synthetic building blocks that confer select and synergistic properties. Owing to opportunities to design predefined architectures and structures with different morphologies, these hybrid conjugates enable new approaches for producing micro- or nanomaterials. Their modular design enables the incorporation of multiple responsive properties into a single conjugate. This review presents recent advances in (poly)peptide-polymer conjugates for drug-delivery applications, with a specific focus on the utility of the (poly)peptide component in the assembly of particles and nanogels, as well as the role of the peptide in triggered drug release.

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Star polymers composed entirely of amino acid building blocks: a route towards stereospecific, biodegradable and hierarchically functionalized stars

Cited by 70 publications

References 25 publications

Antibiofouling polymer interfaces: poly(ethylene glycol) and other promising candidates

Antibiofouling polymer interfaces: poly(ethylene glycol) and other promising candidates

Imaging‐Guided pHe and Glutathione Dual Responsive Polypeptide Nanogel for Smart Drug Delivery

Responsive hybrid (poly)peptide–polymer conjugates

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