Star Polymer Translocation into a Spheroidal Cavity

Nagarajan, K.; Chen, Shing Bor

doi:10.1002/mats.202000032

Cited by 2 publications

(2 citation statements)

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“…[60] Moreover, the authors also employed LD simulations to investigate star polymer translocation into a spheroidal cavity subject to an external electric field inside the pore. [61] For a fixed value of the chain total mass, they found that 〈τ〉 displays non-monotonic variation with respect to f for large cavities, while it decreases monotonically with f for sufficiently small cavities.…”

Section: Introductionmentioning

confidence: 96%

End‐Pulled Translocation of a Star Polymer Out of a Confining Cylindrical Cavity

Tilahun

Tatek

2021

Macro Theory & Simulations

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dispersant, potential drug delivery agents, thermoplastic elastomers, surfactants, and lubricants. [2,3,5] In addition, more recently, there is an increased interest in the biomedical field for using star-shaped macromolecules as drug release carriers by immobilizing biologically active molecules on their arms. [6-8] Polymer translocation through a nanopore is a fundamental process in diverse biological systems, including DNA and RNA translocation across nuclear pores, protein transport through membrane channels, and virus injections. [9-12] It also has advanced applications in rapid DNA sequencing, gene therapy, and controlled drug delivery. [13-20] Moreover, the study of translocation has involved complex setups such as gel matrix usage on different sides of a plane wall, [21-23] polymer ejection from micro-channels [24] and nanometric size channels, [25] and DNA molecules trapping inside a bounded cavity during the course of translocation. [26] In this respect, several experimental, [27-32] numerical, [33-38] and theoretical [39-51] studies have focused on the dynamical aspect of the translocation mechanism of linear chains [52-57] as well as star polymers. [58-61] Forced and unforced translocations of linear polymers through nanoscopic pores have been extensively studied and are still the topic of theoretical, numerical, and experimental investigations. [62-64] These processes are often complex by their own right, a complexity due to the great number of parameters involved. Indeed, translocation processes can be affected by different factors, such as the initial chain conformation, the size of the chain, the driving force (if any), and the confining geometry. For instance, forced translocation may involve the presence of a flowing fluid due to a chemical difference between the two sides of the pore, [65,66] of an electric field in the case of charged polymers, [67,68] or of a pulling force applied on a portion of the chain. [69,70] Huopaniemi et al. have studied the scaling relation between the mean translocation time 〈τ〉 and the chain mass N for a single linear chain subject to a pulling force F. [53] The authors suggested 〈τ〉 ≈ N 2 for both strong and moderate forces. They also found that 〈τ〉 scales with N as 〈τ〉 ≈ N 2ν + 1 for weak force regime, where ν is the Flory exponent in good solvent. The distribution of translocation times was found to be symmetric and narrow for strong F. Furthermore, they have found that the dependence of the mean translocation time on pulling force exhibits a scaling relation 〈τ〉 ≈ F −1. D. Sean and G. W. Slater A Langevin dynamics computer simulation is carried out to study the translocation of a single homogeneous star polymer out of a cylindrical cavity connected to a membrane wall with a circular nanopore along the tube axis. The ejection process is driven through an external pulling force applied on the free end monomer of the chain leading arm. The results show that, for a given chain mass and for relatively narrow pores, the mean translocation time 〈τ〉 exhibits a non-mono...

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Section: Introductionmentioning

confidence: 96%

End‐Pulled Translocation of a Star Polymer Out of a Confining Cylindrical Cavity

Tilahun

Tatek

2021

Macro Theory & Simulations

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“…[51] Zhang and Luo have studied the driven translocation of a polymer into a circular confinement through a small pore, and found that the scaling exponent of the translocation time with the polymer length is dependent on the driving force and the monomer density of the whole polymer in the circular confinement. [52] Other studies indicated that the packaging of polymers into a cavity is a complex dynamical process, which is affected by many other factors, such as the attractive interaction between the polymer and the inner wall of the cavity, [30] the geometry of the cavity, [53][54][55] the flexibility of the polymer, [51,56] the temperature of the solvent, [57] the topology of the polymer, [58] etc.…”

Section: Introductionmentioning

confidence: 99%

Driven injection of a polymer into a spherical cavity: A Langevin dynamics simulation study*

Wang¹,

Wu²,

Yang³

et al. 2021

Chinese Phys. B

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The injection of a self-avoiding flexible polymer into a spherical cavity under a driving force is studied by using Langevin dynamics simulation. For given polymer length (N) and driving force ( f ), the polymer can be completely injected into the cavity only when the radius of the cavity is larger than a transition radius (R eC ). The dependence of R eC on N and f can be described by a scaling relation R eC ∝ N 1/3 f −δ . The value of δ changes from 4/15 in the small f region to 1/6 in the moderate f region due to the screening of the excluded-volume interaction between monomers. We find the complete injection time (τ) decreases monotonously with increasing the cavity radius or decreasing the polymer length. The simulation results are in good agreement with the theoretical predictions from the free energy analysis and a simple kinetic model.

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Star Polymer Translocation into a Spheroidal Cavity

Cited by 2 publications

References 42 publications

End‐Pulled Translocation of a Star Polymer Out of a Confining Cylindrical Cavity

End‐Pulled Translocation of a Star Polymer Out of a Confining Cylindrical Cavity

Driven injection of a polymer into a spherical cavity: A Langevin dynamics simulation study*

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