We use 101 galaxies selected from the Nearby Field Galaxy Survey (NFGS) to investigate the effect of aperture size on the star formation rate, metallicity and reddening determinations for galaxies. Our sample includes galaxies of all Hubble types except ellipticals with global SFRs ranging from 0.01 to 100 M ⊙ yr −1 , metallicities between 7.9 log(O/H) + 12 9.0, and reddening between 0 A(V ) 3.3. We compare the star formation rate, metallicity and reddening derived from nuclear spectra to those derived from integrated spectra. For apertures capturing < 20% of the B 26 light, the differences between nuclear and global metallicity, extinction and star formation rate are substantial. Latetype spiral galaxies show the largest systematic difference of ∼ 0.14 dex in the sense that nuclear metallicities are greater than the global metallicities. Sdm, Im, and Peculiar types have the largest scatter in nuclear/integrated metallicities, indicating a large range in metallicity gradients for these galaxy types or clumpy metallicity distributions. We find little evidence for systematic differences between nuclear and global extinction estimates for any galaxy type. However, there is significant scatter between the nuclear and integrated extinction estimates for nuclear apertures containing < 20% of the B 26 flux. We calculate an 'expected' star formation rate using our nuclear spectra and apply the commonly-used aperture correction method. The expected star formation rate overestimates the global value for early type spirals, with large scatter for all Hubble types, particularly late types. The differences between the expected and global star formation rates probably result from the assumption that the distributions of the emission-line gas and the continuum are identical. The largest scatter (error) in the estimated SFR occurs when the aperture captures < 20% of the B 26 emission. We discuss the implications of these results for metallicity-luminosity relations and star-formation history studies based on fiber spectra. To reduce systematic and random errors from aperture effects, we recommend selecting samples with fibers that capture > 20% of the galaxy light. For the Sloan Digital Sky Survey and the 2dFGRS, redshifts z > 0.04 and z > 0.06 are required, respectively, to ensure a covering fraction > 20% for galaxy sizes similar to the average size, type, and luminosity observed in our sample. Higher-luminosity samples and samples containing many late-type galaxies require a larger minimum redshift to ensure that > 20% of the galaxy light is enclosed by the fiber.