Staphylococcus pseudintermedius versus Staphylococcus intermedius

Devriese, Luc; Hermans, Katleen; Baele, Margo; Haesebrouck, Freddy

doi:10.1016/j.vetmic.2008.06.002

Cited by 113 publications

(87 citation statements)

References 7 publications

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“…S. pseudintermedius is the principal cause of pyoderma and otitis in canine [24]. Although it had been misidentified for decades as S. intermedius, recent analyses by molecular phylogenetic and PCR-restriction fragment length polymorphism (PCR-RFLP) approaches indicated that S. pseudintermedius, not S. intermedius, is the major canine pyoderma pathogen [6,23,25], and it has already been proposed that all strains from dogs identified by traditional means be reported as S. pseudintermedius [6,11]. Increasing resistance of this organism and failures to treat canine pyoderma or otitis with a number of antibacterial agents, including fluoroquinolones were reported recently [6,30].…”

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The <i>In Vitro</i> Activity of 15 Antimicrobial Agents against Bacterial Isolates from Dogs

Awji

Damte

Lee

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. The in vitro activity of 15 antimicrobial agents against clinical isolates of Staphylococcus pseudintermedius, Staphylococcus aureus, Escherichia coli, Pasteurella spp. and Streptococcus canis from dogs was investigated. For Staphylococcus spp., the highest frequency of resistance was observed for penicillin, followed by ampicillin, tetracycline and chloramphenicol. The highest frequency of resistance in E. coli isolates was recorded for tetracycline and streptomycin. Pasteurella spp. and S. canis had the highest resistance rate for tetracycline and chloramphenicol. Most isolates showed full susceptibility to low-level resistance to colistin, florfenicol and fluoroquinolones. Further studies using larger number of isolates from both healthy and diseased dogs would provide a broader picture of antimicrobial resistance at a national level and promote prudent use of antimicrobial agents in companion animals. Antibacterial drug resistance continues to increase worldwide, with some pathogenic bacteria exhibiting resistance to virtually all available drugs [29]. While there are considerable, though often fragmented, data on the quantities of antimicrobial drug use and resistance in bacteria of food animal origin, useful data on antimicrobial drug use and resistance in companion animals are relatively scarce [22,24]. The most frequent bacterial infections in dogs include skin, ear, wound, gastrointestinal and urinary tract infections. Staphylococcus pseudintermedius, Escherichia coli, Pseudomonas aeruginosa, Streptococcus spp. and Proteus spp. are among the most frequently encountered bacterial pathogens in companion animal veterinary practice. The antimicrobial drug susceptibilities of canine isolates have been reported [1,7,9,23], most of which have also zoonotic significance. S. pseudintermedius is the principal cause of pyoderma and otitis in canine [24]. Although it had been misidentified for decades as S. intermedius, recent analyses by molecular phylogenetic and PCR-restriction fragment length polymorphism (PCR-RFLP) approaches indicated that S. pseudintermedius, not S. intermedius, is the major canine pyoderma pathogen [6,23,25], and it has already been proposed that all strains from dogs identified by traditional means be reported as S. pseudintermedius [6,11]. Increasing resistance of this organism and failures to treat canine pyoderma or otitis with a number of antibacterial agents, including fluoroquinolones were reported recently [6,30]. Furthermore, cross-resistance between fluoroquinolones and other antibacterial agents and zoonotic transmission of both meticillin-susceptible and meticillin-resistant S. pseudintermedius between dogs and humans have been concerns recently [30,31]. Resistance in canine E. coli isolates to a wide range of antimicrobial agents, including fluoroquinolones, is increasingly reported [2]. Furthermore, the chemical and structural similarities between veterinary and human-use drugs and the close phylogenetic relationships between E. coli isolates from dogs and man have r...

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The <i>In Vitro</i> Activity of 15 Antimicrobial Agents against Bacterial Isolates from Dogs

Awji

Damte

Lee

et al. 2012

The Journal of Veterinary Medical Science

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“…Recently, however, genotypic analyses revealed that it belongs to the Staphylococcus intermedius group (SIG), which comprises S. intermedius, S. pseudintermedius, and S. delphini [1,2]. It is the opportunistic bacteria that colonizes and clinically infects dogs and cats [3] and occasionally other animals [3,4], including humans [5].…”

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Occurrence of toxin genes in Staphylococcus pseudintermedius from diseased dogs and other domestic and wild species

Pitchenin

Brandão

Rosa

et al. 2018

J Infect Dev Ctries

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Introduction: Staphylococcus pseudintermedius is coagulase-positive species of the Staphylococcus intermedius group. It is an opportunistic pathogen that can cause infection in various parts of the body and has a zoonotic potential. Although studies on the pathogenicity and epidemiology of S. pseudintermedius are limited, it is known that this bacterium has several virulence factors, including toxins. These toxins can be classified into three main groups: pyrogenic toxins with superantigenic properties such as toxic shock syndrome toxin and staphylococcal enterotoxins, exfoliative toxins, and cytotoxins such as hemolysins and leukocidins. Methodology: In this study, the occurrence of eight toxin genes (sea, sec, tst, SIET, EXI, LuK F-I, Luk S-I, and hlg ƴ) was examined by PCR in 58 isolates of S. pseudintermedius from four domestic animal species. Results: All S. pseudintermedius isolates had at least one of the eight toxin genes. The predominant toxin genes were Luk S-I (95%), Luk F-I (91%), and EXI (91%), and the least prevalent gene was hlg ƴ (5%). Significant association (p = 0.0175) was found between the occurrence patterns of genes hlg ƴ and Luk F-I. Conclusions: The frequent occurrence of these genes in S. pseudintermedius obtained from diseased animals indicates that these toxins may play an important role in the pathogenesis of infection among domestic animals.

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“…Os principais agentes etiológicos são bactérias do gênero Staphylococcus (Cox 2006, Ihrke 2006, sendo Staphylococcus pseudintermedius (S. pseudintermedius) anteriormente referido como S. intermedius (Mason 1991, Hill & Moriello 1994, Scott et al 2001), a espécie mais comumente isolada (Gross et al 2005, Devriese et al 2009, Hnilica 2011. Na maioria dos casos, a piodermite superficial é considerada uma manifestação secundária de outras alterações cutâneas ou sistê-micas e os animais acometidos podem apresentar quadros recorrentes dessa infecção como uma importante complicação da doença subjacente (Scott et al 2001).…”

Section: Introductionunclassified

Suscetibilidade antimicrobiana de Staphylococcus spp. isolados de cães com pioderma superficial

et al. 2014

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Foram obtidas 154 amostras de lesões cutâneas de cães com pioderma superficial atendidos no Serviço de Dermatologia Veterinária do Hospital Veterinário Universitário (HVU) da Universidade Federal de Santa Maria (UFSM), com o objetivo de determinar a suscetibilidade antimicrobiana de isolados de Staphylococcus spp. e avaliar a presença de multirresistência. Após isolamento e identificação, as cepas foram submetidas ao teste de sensibilidade aos antimicrobianos, cujos resultados evidenciaram menores percentuais de resistência à associação amoxicilina e ácido clavulânico (1,9%), cefadroxil (1,9%), cefalexina (1,9%) e vancomicina (0,6%). Os maiores percentuais de resistência foram frente à amoxicilina (60,4%) e penicilina G (60,4%). A multirresistência foi detectada em 23,4% e a resistência à meticilina em 5,8% das amostras. Pode-se concluir que os isolados de Staphylococcus spp. apresentam elevada suscetibilidade aos antimicrobianos comumente utilizados no tratamento dos piodermas superficiais em cães atendidos no HVU-UFSM, como a cefalexina e a amoxicilina associada ao ácido clavulânico, confirmando a eleição desses fármacos para o tratamento de cães com esta afecção. A suscetibilidade diminuída das cepas frente às fluoroquinolonas, também recomendadas pela literatura para o tratamento de pioderma, permite sugerir que estes fármacos não devem mais ser considerados na seleção empírica. A identificação de Staphylococcus spp. multirresistentes na população canina estudada justifica análises bacteriológicas periódicas e regionais de lesões cutâneas de cães com pioderma superficial, a fim de minimizar a seleção de bactérias resistentes, possíveis falhas terapêuticas e também motiva a antimicrobianoterapia prudente.

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Staphylococcus pseudintermedius versus Staphylococcus intermedius

Cited by 113 publications

References 7 publications

The <i>In Vitro</i> Activity of 15 Antimicrobial Agents against Bacterial Isolates from Dogs

The <i>In Vitro</i> Activity of 15 Antimicrobial Agents against Bacterial Isolates from Dogs

Occurrence of toxin genes in Staphylococcus pseudintermedius from diseased dogs and other domestic and wild species

Suscetibilidade antimicrobiana de Staphylococcus spp. isolados de cães com pioderma superficial

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