Staphylococcus lugdunensis endocarditis

Shuttleworth, R; Colby, W. David

doi:10.1128/jcm.30.8.1948-1952.1992

Cited by 43 publications

(20 citation statements)

References 23 publications

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“…S lugdunensis is a virulent organism, and our patients protracted illness was consistent with this. Although there are no documented cases of right-sided endocarditis, the mortality rate of S lugdunensis mitral valve endocarditis is approximately 50% (3,6). Our patient's successful outcome was in keeping with the general trend of better survival in cases of right-sided endocarditis.…”

Section: Discussionsupporting

confidence: 73%

“…In one study, 85% of isolates were considered pathogens. It has been implicated in infections of the skin (4), brain (5), bone (5), peritoneum (5), and prosthesis (5) and left-sided heart valves (3,6). After searching MEDLINE, we have found that our case is the first documented episode of tricuspid valve endocarditis caused by this virulent organism.…”

Section: Discussionmentioning

confidence: 88%

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Right‐Sided Endocarditis due to Staphylococcus lugdunensis: First Reported Case

Choudhri

Hoeschen

1998

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Staphylococcus lugdunensis is a coagulase-negative organism first identified in 1988. It is often incorrectly identified as Staphylococcus aureus, and has been isolated as the etiological agent in over 20 cases of left-sided endocarditis. This report describes the first documented case of right-sided endocarditis caused by S lugdunensis. This experience suggests that S lugdunensis can infect native valves in the absence of any predisposing risk factors such as injection drug use.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 88%

Right‐Sided Endocarditis due to Staphylococcus lugdunensis: First Reported Case

Choudhri

Hoeschen

1998

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…Occasionally, CoNS other than S. epidermidis, S. haemolyticus, and S. hominis cause serious infections (8,14), and in certain infections, such as shunt-associated meningitis and endocarditis, beta-lactam drugs are the preferred therapy. Susceptibility tests will define all CoNS for which the oxacillin MIC is Ն0.5 mg/liter as methicillin resistant, regardless of the species and the status of the mecA gene.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Oxacillin MIC with mecA Gene Carriage in Coagulase-Negative Staphylococci

et al. 2000

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The National Committee for Clinical Laboratory Standards has recently changed the oxacillin breakpoint from ≥4 mg/liter to ≥0.5 mg/liter to detect methicillin-resistant coagulase-negative staphylococci (CoNS) because the previous breakpoint lacked sensitivity. To determine the correlation between the new oxacillin breakpoint and the presence of themecA gene, 493 CoNS of 11 species were tested. The presence of the mecA gene was determined by PCR, and oxacillin susceptibility was determined by the agar dilution method with Mueller-Hinton agar containing 2% NaCl and oxacillin (0.125 to 4.0 mg/liter). The new breakpoint correctly classified all CoNS strains with mecA as methicillin resistant and strains ofStaphylococcus epidermidis, S. haemolyticus, and S. hominiswithout mecA as methicillin susceptible. The breakpoint of ≥0.5 mg/liter was not specific for S. cohnii, S. lugdunensis, S. saprophyticus, S. warneri, and S. xylosus, in that it categorized 70 of 74 strains of these species withoutmecA (94.6%) as methicillin resistant. The results of this study indicate that the new oxacillin breakpoint accurately identifies strains of CoNS with mecAbut is not specific for strains of certain species of CoNS withoutmecA.

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“…13.14 In addition, S lugdunensis can have weak production of thermostable DNase. 10,13,14 Use of the "API Staph gallery" may identify the strains as Staphylococcus hominis, since acid can be produced from lactose, maltose, fructose, trehalose, and sucrose and not from mannitol and xylitol. However, S lugdunensis differs from both S aureus and S hominis by ornithine decarboxylase activity.…”

Section: Discussionmentioning

confidence: 99%