Staphylococcus lugdunensis: case report and discussion

Donoghue, Stephen; Vekic, Dunja Ana; Wehrhahn, Michael C; Whitfeld, Margot

doi:10.1111/ajd.12209

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…S. capitis, which could be emerging opportunistic pathogens [20]. Further, S. lugdunensis has been reported to be a highly virulent CoNS species, and it is likely to be underreported [21], [22]. The detection of S. haemolyticus as the most frequent species in our study could be related to many reports about the high prevalence of this organism in the hospital environment and its importance as a cause of hospital-acquired infection [3], [20].…”

Section: Discussionsupporting

confidence: 50%

Prevalence of methicillin resistance and macrolide–lincosamide–streptogramin B resistance in Staphylococcus haemolyticus among clinical strains at a tertiary-care hospital in Thailand

Teeraputon

Santanirand

Wongchai

et al. 2017

New Microbes and New Infections

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Staphylococcus spp. is a major cause of nosocomial infection and sepsis. However, increasing drug resistance is becoming a challenge to microbiologists. The purpose of this study was to identify and determine antimicrobial resistance phenotypes and drug resistance genes of clinical coagulase-negative staphylococci (CoNS) isolates at Mae Sot Hospital in Tak province, Thailand. A total of 229 CoNS isolates were collected from clinical specimens during two periods in 2014 and in 2015. Staphylococcus haemolyticus was the most prevalent species (37.55%), followed by S. epidermidis (21.83%), S. saprophyticus (11.79%) and S. hominis (11.35%) respectively. The remaining 17.48% of the organisms comprised S. capitis, S. arlettae, S. cohnii, S. equorum, S. xylosus, S. warneri, S. sciuri, S. pettenkoferi, S. kloosii and S. lugdunensis. Methicillin-resistant CoNS (MRCoNS), containing the mecA gene, were detected in 145 of 229 isolates, mostly found in S. haemolyticus and S. epidermidis. In addition, the differentiation of their macrolide–lincosamide–streptogramin B (MLSB) resistance phenotypes was determined by the D-test and corresponding resistance genes. Among 125 erythromycin-resistant CoNS, the prevalence of constitutive type of MLSB, inducible clindamycin resistance and macrolide–streptogramin B resistance phenotypes were 72, 13.60 and 14.40% respectively. These phenotypes were expressed in 80% of MRCoNS strains. In addition, the ermC gene (79.20%) was found to be more prevalent than the ermA gene (22.40%), especially among MRCoNS. These results indicate that CoNS may play an important role in spreading of drug resistance genes. More attention to these organisms in surveillance and monitoring programs is needed.

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Section: Discussionsupporting

confidence: 50%

Prevalence of methicillin resistance and macrolide–lincosamide–streptogramin B resistance in Staphylococcus haemolyticus among clinical strains at a tertiary-care hospital in Thailand

Teeraputon

Santanirand

Wongchai

et al. 2017

New Microbes and New Infections

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“…2,3 The incidence of S. lugdunensis infections is rising; thus, it is considered to be an emerging pathogen in skin and soft tissue infections. [4][5][6] The present study was performed to elucidate the types of skin infection caused by S. lugdunensis and their management, encountered in a tertiary referral medical center.…”

Section: Introductionmentioning

confidence: 99%

“…Clinical manifestations include abscesses, surgical wound infection and cellulitis, commonly in the groin and breast, in both healthy and immunosuppressed individuals . The incidence of S. lugdunensis infections is rising; thus, it is considered to be an emerging pathogen in skin and soft tissue infections . The present study was performed to elucidate the types of skin infection caused by S. lugdunensis and their management, encountered in a tertiary referral medical center.…”

Section: Introductionmentioning

confidence: 99%

Clinical and microbiological properties of Staphylococcus lugdunensis skin infections

Zaaroura

Geffen

Bergman

et al. 2018

The Journal of Dermatology

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Staphylococcus lugdunensis is an emerging pathogen in skin and soft tissue infections that was previously considered a commensal. The aim of this study was to elucidate the characteristics of skin infections by S. lugdunensis and its appropriate management, in a tertiary referral medical center. The clinical files, bacterial cultures and histopathology reports of all S. lugdunensis isolates from skin infections over a period of 8 years (September 2009-September 2017) were reviewed. S. lugdunensis was isolated from 29 patients with skin infections, aged 7-89 years (mean 33.3 years). A state of immune suppression (drug-induced, malignancy or diabetes) was present in five patients (17%). Folliculitis and cutaneous pustulosis were the most common presentations (16 cases, 55%), followed by secondary infection of hidradenitis suppurativa (five cases, 17%). Other sources of isolation were infected molluscum contagiosum (two cases), folliculitis decalvans (one case), dissecting cellulitis (one case), abscess (one case), cyst (one case), impetigo (one case) and granuloma after trauma (one case). The in vitro antibiotic sensitivity tests showed susceptibility to most tested antibiotics, although a few isolates were resistant to gentamycin, penicillin and oxacillin. In 19 of 20 patients for whom follow ups were available, cutaneous manifestations improved or resolved with proper local and/or oral antibiotic therapy. S. lugdunensis may play a role as a primary or secondary pathogen in various skin infections, most commonly folliculitis and pustulosis. Proper antibiotic therapy may lead to improvement or resolution.

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“…The organism is found as a skin commensal in healthy individuals, although it has been implicated in invasive diseases, especially fulminant native, prosthetic-valve endocarditis [2], brain abscess, meningitis, soft tissue infections, spondylodiscitis, foreign body infections, and peritonitis [3]. S. lugdunensis has been largely unreported in the dermatology literature, even though the skin has been consistently demonstrated to be the most common site of clinically significant infection [4]. Sporotrichoid distribution of skin lesions (also called nodular lymphangitis) can be caused by many fungal and bacterial infections.…”

Section: Introductionmentioning

confidence: 99%