Staphylococcus cohnii as a cause of multiple brain abscesses in Weber–Christian disease

Yamashita, Satoshi; Yonemura, Kensuke; Sugimoto, Ryoko; Tokunaga, Makoto; Uchino, Makoto

doi:10.1016/j.jns.2005.06.009

Cited by 11 publications

(5 citation statements)

References 10 publications

(11 reference statements)

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“…Sand flies from Gaya had the most B. linens, whereas sand flies from Bacillus pumilus 28,29 Bacillus subtilis [30][31][32][33] Brevibacterium casei [34][35][36] Brevibacterium iodinum 37 Cellulomonas spp. 38 Gordonia terrae [39][40][41] Microbacterium oxydens 42 Staphylococcus cohnii [43][44][45] Bahapur more commonly harbored other species of Brevibacterium. Table 6 looks specifically at B. linens and B. megaterium because of their lack of pathogenicity and potential application in future paratransgenesis work.…”

Section: Resultsmentioning

confidence: 99%

Identification of Aerobic Gut Bacteria from the Kala Azar Vector, Phlebotomus argentipes: A Platform for Potential Paratransgenic Manipulation of Sand Flies

Hillesland

Read²,

Subhadra³

et al. 2008

Am J Trop Med Hyg

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Visceral leishmaniasis is an understudied parasitic disease responsible for significant global morbidity and mortality. We are presently investigating a method of disease prevention termed paratransgenesis. In this approach, symbiotic or commensal bacteria are transformed to produce anti-Leishmania molecules. The transformed bacteria are delivered back to sand flies to inactivate the parasite within the vector itself. In this study, we identified 28 distinct gut microorganisms from Phlebotomus argentipes trapped from four visceral leishmaniasis-endemic sites in India. A significant percent of Staphylococcus spp., environmental bacteria, and Enterobacteriaceae were identified. Two non-pathogenic organisms, Bacillus megaterium and Brevibacterium linens, were also isolated. Both organisms are also used extensively in industry. Our results indicate that B. megaterium and B. linens are possible candidates for use in a model of paratransgenesis to prevent transmission of Leishmania.

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Section: Resultsmentioning

confidence: 99%

Identification of Aerobic Gut Bacteria from the Kala Azar Vector, Phlebotomus argentipes: A Platform for Potential Paratransgenic Manipulation of Sand Flies

Hillesland

Read²,

Subhadra³

et al. 2008

Am J Trop Med Hyg

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“…S. cohnii subsp urealyticus is an unusual opportunist species that has been found in hospital environment like pediatric ICUs (24), and may constitute a dangerous reservoir of multiple antimicrobial plasmid mediated resistance genes (21,23). …”

Section: Resultsmentioning

confidence: 99%

Oxacilin-resistant Coagulase-negative staphylococci (CoNS) bacteremia in a general hospital at São Paulo city, Brasil

d’Azevedo

Secchi

Antunes

et al. 2008

Braz. J. Microbiol.

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In the last decades, coagulase-negative staphylococci (CoNS), especially Staphylococcus epidermidis have become an important cause of bloodstream infections. In addition, rates of methicillin-resistance among CoNS have increased substantially, leading to the use of glicopeptides for therapy. The objective of this study was to evaluate eleven consecutives clinically relevant cases of oxacillin-resistant CoNS bacteremia in a general hospital localized in São Paulo city, Brazil. Five different species were identified by different phenotypic methods, including S. epidermidis (5), S. haemolyticus (3), S. hominis (1), S. warneri (1) and S. cohnii subsp urealyticus (1). A variety of Pulsed Field Gel Electrophoresis profiles was observed by macrorestriction DNA analysis in S. epidermidis isolates, but two of three S. haemolyticus isolates presented the same profile. These data indicated the heterogeneity of the CoNS isolates, suggesting that horizontal dissemination of these microorganisms in the investigated hospital was not frequent. One S. epidermidis and one S. haemolyticus isolates were resistant to teicoplanin and susceptible to vancomycin. The selective pressure due to the use of teicoplanin in this hospital is relevant.

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“…NCBI BLAST analysis of 16S rRNA gene sequencing revealed that the coagulase-negative Staphylococcus isolated from the infected implant showed 100% sequence identity to S. cohnii . This organism is of clinical relevance, given that S. cohnii has been reported to be pathogenic in human diseases, − and is frequently reported during screens for coagulase-negative staphylococci present in the clinical environment . Alarmingly, one study indicated S. cohnii was the predominant species isolated in an ICU pediatric ward, with 97% of the S. cohnii isolates resistant to methicillin .…”

Section: Resultsmentioning

confidence: 99%

Biofilm Inhibition via Delivery of Novel Methylthioadenosine Nucleosidase Inhibitors from PVA-Tyramine Hydrogels while Supporting Mesenchymal Stromal Cell Viability

Mutreja

Warring

Lim

et al. 2018

ACS Biomater. Sci. Eng.

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The rise of antibiotic resistance, coupled with increased expectations for mobility in later life, is creating a need for biofilm inhibitors and delivery systems that will reduce surgical implant infection. A limitation of some of these existing delivery approaches is toxicity exhibited toward host cells. Here, we report the application of a novel inhibitor of the enzyme, methylthioadenosine nucleosidase (MTAN), a key enzyme in bacterial metabolic pathways, which include S-adenosylmethionine catabolism and purine nucleotide recycling, in combination with a poly(vinyl alcohol)-tyramine-based (PVA-Tyr) hydrogel delivery system. We demonstrate that a lead MTAN inhibitor, selected from a screened library of 34 candidates, (2S)-2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-ylmethyl)aminoundecan-1-ol (31), showed a minimum biofilm inhibitory concentration of 2.2 ± 0.4 μM against a clinical staphylococcal species isolated from an infected implant. We observed that extracellular DNA, a key constituent of biofilms, is significantly reduced when treated with 10 μM compound 31, along with a decrease in biofilm thickness. Compound 31 was incorporated into a hydrolytically degradable photo-cross-linked PVA-Tyr hydrogel and the release profile was evaluated by HPLC studies. Compound 31 released from the PVA-hydrogel system significantly reduced biofilm formation (77.2 ± 8.4% biofilm inhibition). Finally, compound 31 released from PVA-Tyr showed no negative impact on human bone marrow stromal cell (MSC) viability, proliferation, or morphology. The results demonstrate the potential utility of MTAN inhibitors in treating infections caused by Gram-positive bacteria, and the development of a nontoxic release system that has potential for tunability for time scale of delivery.

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Staphylococcus cohnii as a cause of multiple brain abscesses in Weber–Christian disease

Cited by 11 publications

References 10 publications

Identification of Aerobic Gut Bacteria from the Kala Azar Vector, Phlebotomus argentipes: A Platform for Potential Paratransgenic Manipulation of Sand Flies

Identification of Aerobic Gut Bacteria from the Kala Azar Vector, Phlebotomus argentipes: A Platform for Potential Paratransgenic Manipulation of Sand Flies

Oxacilin-resistant Coagulase-negative staphylococci (CoNS) bacteremia in a general hospital at São Paulo city, Brasil

Biofilm Inhibition via Delivery of Novel Methylthioadenosine Nucleosidase Inhibitors from PVA-Tyramine Hydrogels while Supporting Mesenchymal Stromal Cell Viability

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