2007
DOI: 10.1001/archderm.143.10.1259
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Staphylococcus aureus Virulence Factors Associated With Infected Skin Lesions

Abstract: To evaluate Staphylococcus aureus isolates from infected skin lesions for their potential to produce immune system-modulating toxins and to correlate these with white blood cell (WBC) counts associated with these lesions. Design: Specimens were obtained for bacterial culture and gram staining from 105 infected skin lesions, and the number of WBCs per low-power field (LPF) was determined. Chromosomal DNA was prepared from 84 bacterial isolates and subjected to real-time polymerase chain reaction analysis to det… Show more

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Cited by 31 publications
(23 citation statements)
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“…Peptides originating from the proteinase K-chymotrypsin method (shaving approach) were separated only in one dimension but over a long LC gradient that was run in six replicates (number of protein identifications in single replicates: 121, 118, 112, 122, 132, and 135) approaching a saturation in the number of protein identifications. 2 Detailed information on the protein identification for each of the three techniques introduced is provided in supplemental Tables S4 -S6. Furthermore the corresponding Scaffold files and results of single replicates including MS/MS spectra for all peptide identifications are available upon request.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Peptides originating from the proteinase K-chymotrypsin method (shaving approach) were separated only in one dimension but over a long LC gradient that was run in six replicates (number of protein identifications in single replicates: 121, 118, 112, 122, 132, and 135) approaching a saturation in the number of protein identifications. 2 Detailed information on the protein identification for each of the three techniques introduced is provided in supplemental Tables S4 -S6. Furthermore the corresponding Scaffold files and results of single replicates including MS/MS spectra for all peptide identifications are available upon request.…”
Section: Resultsmentioning
confidence: 99%
“…The human pathogenic bacterium Staphylococcus aureus causes a wide variety of diseases ranging from minor skin infections (1,2) to critical endocarditis (3,4) and sepsis (5). The spreading of multiresistant S. aureus strains and the increasing number of lethal infections worldwide is most alarming.…”
mentioning
confidence: 99%
“…Exfoliative toxins are proteinase from S. aureus, which digest desmoglein 1, resulting in exfoliation of the epidermis cells [190]. Exfoliative toxin involves ETA, ETB, and ETD.…”
Section: Exfoliative Toxinsmentioning
confidence: 99%
“…Staphylococcus aureus , a persistent nasal colonizer in approximately one-third of the human population [1], causes infections ranging from superficial skin lesions to life-threatening syndromes such as endocarditis, osteomyelitis, toxic shock, and sepsis [24]. Indeed, S. aureus is the second leading cause of healthcare-associated bacteremia, accounting for ~13 % of such infections.…”
Section: Introductionmentioning
confidence: 99%