Staphylococcus aureus Vaccines

Daum, Robert S.

doi:10.1016/b978-0-323-35761-6.00055-9

Cited by 1 publication

(1 citation statement)

References 167 publications

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“…However, it was soon evident that these pathogens are able to become resistant to many of the first effective drugs (Gold and Moellering, 1996). Staphylococcus aureus strains cause a broad spectrum of diseases, ranging from minor skin diseases to serious bloodstream infections (Daum, 2008). In the past, this bacterium has been successfully treated with penicillins, but many strains build up the resistance to ß-lactam antibiotics by the production of ß-lactamase (Andremont et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Determination of anti-staphylococcal activity of thymoquinone in combinations with antibiotics by checkerboard method using EVA capmat™ as a vapor barrier

Rondevaldova

Nový

Urban

et al. 2017

Arabian Journal of Chemistry

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Thymoquinone (Tq) has been reported to potentiate the in vitro growth-inhibitory activity of some antibiotics especially against Staphylococcus aureus. However, it has been shown that Tq vapors can affect the results of susceptibility testing by standard broth microdilution method. Therefore, we made a comparative experiment with and without ethylene vinyl acetate cap mats (EVA capmatä) on microplates. The results showed significant differences in the minimum inhibitory concentration values and proved this capmat as an effective vapor barrier. Therefore further experiments focused on the in vitro anti-staphylococcal combinatory effect of Tq with oxacillin, penicillin, and tetracycline against various S. aureus strains have been performed by checkerboard method using EVA capmatä. The combined effect was evaluated according to the sum of fractional inhibitory concentrations (RFIC). Synergy was obtained for combination with oxacillin against 3

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Section: Introductionmentioning

confidence: 99%