Staphylococcus aureus, T-cell repertoire, and Wegener’s granulomatosis

Hamidou, M.; Audrain, Marie; Ninin, E.; Robillard, Nelly; Muller, Jean‐Yves; Bonneville, Marc

doi:10.1016/s1297-319x(01)00293-7

Cited by 8 publications

(3 citation statements)

References 30 publications

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“…However, this phenomenon was not supported by a similar study in New Zealand [ 17 ]. Infections might contribute to the onset of AAV, especially Staphylococcus aureus infections [ 18 – 20 ]. Moreover, certain genetic backgrounds might lead to greater susceptiblity to AAV [ 21 ], especially in specific races [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

The frequency of ANCA-associated vasculitis in a national database of hospitalized patients in China

Li¹,

Cui²,

Long

et al. 2018

Arthritis Res Ther

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BackgroundAnti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a group of life-threatening autoimmune diseases. The epidemiological data on AAV in China are limited. The aim of the present study is to investigate the frequency, geographical distribution, and ethnic distribution of AAV in hospitalized patients in China, and its association with environmental pollution.MethodsWe investigated the hospitalized patients in a national inpatient database covering 54.1% tertiary hospitals in China from 2010 to 2015. Diagnosis of AAV was extracted according to the definition of International Classification of Diseases (ICD)-10 codes and free text. Variables from the front page of inpatient records were collected and analyzed, including frequency, geographic distribution, demographic characteristics and seasonal variations of AAV. The association between various environmental pollutants and frequency of AAV was further analyzed.ResultsAmong 43.7 million inpatients included in the study period, 0.25‰ (10,943) were diagnosed as having AAV. The frequency of AAV was relatively stable during the study period (from 0.34‰ in 2010 to 0.27‰ in 2015). The proportion of AAV increased with latitude (0.44‰ in Northern China and 0.27‰ in Southern China in 2015). Hospitalizations were mostly observed in winter (30.2%). The Dong population, an ethnic minority of the Chinese population, had the highest frequency of patients with AAV (0.67‰). We also found a positive association between the exposure to carbon monoxide and the frequency of AAV (R2 = 0.172, p = 0.025). In Yunnan province, the frequency of AAV increased 1.37-fold after the Zhaotong earthquake, which took place in 2014.ConclusionsOur present investigation of hospitalized patients provided epidemiological information on AAV in China for the first time. A spatial and ethnic clustering trend and an association between pollution and the frequency of AAV were observed.Electronic supplementary materialThe online version of this article (10.1186/s13075-018-1708-7) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

The frequency of ANCA-associated vasculitis in a national database of hospitalized patients in China

Li¹,

Cui²,

Long

et al. 2018

Arthritis Res Ther

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“…A complex interaction between genetic susceptibility and environmental factors is discussed [3-6], whereas low familiar clustering [7] stresses the importance of the latter.…”

Section: Introductionmentioning

confidence: 99%

Aberrant cytokine pattern of the nasal mucosa in granulomatosis with polyangiitis

et al. 2012

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IntroductionIn granulomatosis with polyangiitis (GPA), a complex autoimmune small-vessel vasculitis frequently associated with chronic necrotizing inflammation of the nasal mucosa, elevated nasal Staphylococcus (S.) aureus carrier rates are a risk factor for relapse. As cytokines are primarily involved in the regulation of defense against potentially pathogenic microorganisms, the aim of this study was to compare healthy individuals and GPA patients with respect to their baseline cytokine expression of nasal epithelial cells (NEC), which form the first barrier against such triggers. The ability of S. aureus to influence the nasal microenvironment's cytokine secretion was assessed by exemplary stimulation experiments.MethodsBaseline expression of 19 cytokines of primary NEC of GPA patients and normal controls (NC) was quantified by a multiplex cytokine assay. Stimulation experiments were performed with supernatants of S. aureus and expression of interleukin-8 was determined by ELISA.ResultsIn GPA, an altered pattern of baseline cytokine expression with significantly up-regulated G-CSF and reduced interleukin (IL)-8 concentrations was observed. Both NEC of GPA patients and NC responded to stimulation with S. aureus, but GPA patients displayed a significantly lower IL-8 secretion and a diminished dynamic range of response towards the stimulus.ConclusionsThe data presented underline the hypothesis of a disturbed epithelial nasal barrier function in GPA. The dysregulated baseline expression of G-CSF and IL-8 and the reduced response to microbial stimulation may facilitate changes in the composition of the nasal flora and favour an imbalanced inflammatory response, which might be relevant for the disease course.

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“…An observation that a patient who received trimethoprim‐sulphamethoxazole (TMP‐SX) for a urinary tract infection with Escherichia coli had an apparent coincident improvement in his or her intercurrent WG, leading to TMP‐SX being used for induction therapy in WG, a situation where, except perhaps for limited nasal disease, its efficacy is suspect, and for maintenance therapy, where it appears to have an adjunctive role 58 . While this may represent an antimicrobial effect, there is no proof of that, and TMP‐SX may also have intrinsic immunosuppressive properties 59 …”

Section: Infectionmentioning

confidence: 99%

Anti‐neutrophil cytoplasmic antibody‐associated systemic vasculitis: nature or nurture?

Gatenby

2012

Internal Medicine Journal

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This review examines the environmental and genetic contributions to the anti-neutrophil cytoplasmic antibody-associated systemic vasculitides. The dominant environmental risk factors appear to be silica exposure for all three syndromes, and vitamin D deficiency is strongly suggested by the latitude and ultraviolet radiation gradient observed for Wegener's granulomatosis and Churg-Strauss syndrome. Genetic factors are generally not very strong, consistent with the rarity of these conditions in children. However, multiple genetic factors, each with a relatively small effect, may combine to create a state of susceptibility towards autoimmunity. With infection as a triggering agent, it is possible to synthesise a pathogenetic hypothesis that accounts for both environmental and genetic effects in regard to both necrotising vasculitis and granuloma formation.

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Staphylococcus aureus, T-cell repertoire, and Wegener’s granulomatosis

Cited by 8 publications

References 30 publications

The frequency of ANCA-associated vasculitis in a national database of hospitalized patients in China

The frequency of ANCA-associated vasculitis in a national database of hospitalized patients in China

Aberrant cytokine pattern of the nasal mucosa in granulomatosis with polyangiitis

Anti‐neutrophil cytoplasmic antibody‐associated systemic vasculitis: nature or nurture?

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