Staphylococcus aureus resistance to albocycline can be achieved by mutations that alter cellular NAD/PH pools

Natural products acting against S. aureus through membrane and cell wall disruption

“…Natural Product Reports Review their study conrmed that albocycline neither targets protein nor peptidoglycan. 156 Daher et al carried out albocycline semisynthetic modication; the representative compound with C4 ester analogue (63, Fig. 18) was twice as potent as albocycline.…”